Research Topics
Genomes and Genes | Manjit HanspalSummaryAffiliation: Tufts University School of Medicine Country: USA Publications
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Publications
Erythrocyte calpain is dispensable for malaria parasite invasion and growthManjit Hanspal
Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Biomedical Research, ACH 406, Boston, MA 02135, USA
Mol Biochem Parasitol 122:227-9. 2002- Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite developmentManjit Hanspal
Department of Biomedical Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Blood 100:1048-54. 2002..It is the proteolysis of skeletal proteins that causes membrane instability, which, in turn, facilitates parasite release in vivo... - Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cellsShikha Dhawan
Department of Biomedical Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
J Biol Chem 278:30180-6. 2003..Confocal microscopy with FP-2-specific antibodies demonstrated the proximity of the enzyme in apposition with the RBC membrane, further corroborating the proposed function of FP-2 in the cleavage of RBC skeletal proteins... - Changing pattern of the subcellular distribution of erythroblast macrophage protein (Emp) during macrophage differentiationShivani Soni
Department of Medicine, Center for Cell Biology, CBR 406, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Blood Cells Mol Dis 38:25-31. 2007..Together, our data show that the temporal and spatial expression of Emp correlates with its role in erythroblastic island formation and suggest that Emp may be involved in multiple cellular functions... - Requirement for erythroblast-macrophage protein (Emp) in definitive erythropoiesisShivani Soni
Department of Medicine, Center of Cell Biology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Blood Cells Mol Dis 41:141-7. 2008..These results demonstrate that Emp plays a cell intrinsic role in the erythroid lineage... - Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusionShivani Soni
Department of Medicine, Center for Cell Biology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
J Biol Chem 281:20181-9. 2006..The availability of an Emp null model provides a unique experimental system to study the enucleation process and to evaluate the function of macrophages in definitive erythropoiesis... - Activation of transglutaminase in mu-calpain null erythrocytesGerald M O'Neill
Department of Medicine, Center for Biomedical Research, CBR 404, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 01235 29, USA
Biochem Biophys Res Commun 307:327-31. 2003..Taken together, these data suggest the existence of a calpain-independent mechanism for the activation of transglutaminase 2 by calcium ions in the mouse erythrocytes and presumably also in non-erythroid cells... - Characterization of events preceding the release of malaria parasite from the host red blood cellShivani Soni
Division of Cell Biology, CBR415, Caritas Street, Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Blood Cells Mol Dis 35:201-11. 2005..In contrast, E64d and MDL caused an irreversible parasite death blocking further development. Future characterization of the mechanism(s) of inhibition may facilitate the design of novel antimalarial inhibitors... - Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell divisionShashi Bala
Center of Cell Biology, Department of Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Biochem Biophys Res Commun 342:1040-8. 2006..These results suggest that Emp undergoes dynamic rearrangements within the nuclear architecture that are correlated with cell division... - Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathwaysMohini Lutchman
Section of Hematology Oncology Research, Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
Eur J Biochem 269:638-49. 2002.... - Cloning and characterization of Plasmodium falciparum cysteine protease, falcipain-2BJong-Jin Jeong
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60561, USA
Blood Cells Mol Dis 36:429-35. 2006..Notwithstanding its predicted hemoglobinase function, the P. falciparum falcipain-2B may contribute and orchestrate selective proteolytic events during the exit of malaria parasite from human red blood cells... - Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agentsNicola Micale
Dipartimento Farmaco Chimico, University of Messina, Viale Annunziata, 98168, Messina, Italy
J Med Chem 49:3064-7. 2006..Compounds 1a-j provided significant inhibitory activity against falcipains 2A and 2B (FP-2A and FP-2B), two cysteine proteases from Plasmodium falciparum...