Research Topics
Species | Bela AsztalosSummaryAffiliation: Tufts University Country: USA Publications
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Publications
Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patientsBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
Atherosclerosis 164:361-9. 2002..The order of efficacy of statins in increasing alpha-1 HDL subpopulation was: atorvastatin, simvastatin, pravastatin, lovastatin and fluvastatin...- Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention TrialBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Metabolism 57:77-83. 2008..It is quite possible that much of the cardiovascular benefits of gemfibrozil are due to a much wider spectrum of effects on metabolic processes that is not reflected by changes in blood lipids and HDL subpopulations... - Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteinsBela F Asztalos
Cardiovascular Research Laboratory, Tufts University, Boston, Massachusetts, USA
Am J Cardiol 99:681-5. 2007..In conclusion, our data show that both statins, given at their maximal doses, favorably alter the HDL subpopulation profile, but also that rosuvastatin is significantly more effective in this regard than atorvastatin... - Role of LCAT in HDL remodeling: investigation of LCAT deficiency statesBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 48:592-9. 2007.... - LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention TrialBela F Asztalos
Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
Atherosclerosis 188:59-67. 2006..We tested the hypothesis that concentrations of LpA-I and/or LpA-I:A-II HDL subclasses are significantly associated with CHD prevalence and recurrent cardiovascular events... - Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention TrialBela F Asztalos
Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 25:2185-91. 2005.... - Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol effluxBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 46:2246-53. 2005..Cholesterol efflux via the SR-BI pathway is associated with several HDL subpopulations with different apolipoprotein composition, lipid content, and size... - Protease inhibitor-based HAART, HDL, and CHD-risk in HIV-infected patientsBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA 02111, USA
Atherosclerosis 184:72-7. 2006.... - Metabolic and functional relevance of HDL subspeciesBela F Asztalos
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Curr Opin Lipidol 22:176-85. 2011..Our purpose is to review recent findings highlighting the metabolic and functional diversity of HDL subspecies... - High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring StudyBela F Asztalos
Lipid Metabolism Laboratory, HNRCA at Tufts University, 711 Washington Street, Boston, Mass 02111, USA
Arterioscler Thromb Vasc Biol 24:2181-7. 2004..We tested the hypothesis whether specific HDL subpopulations are significantly associated with CHD-prevalence... - High-density lipoprotein metabolism and progression of atherosclerosis: new insights from the HDL Atherosclerosis Treatment StudyBela F Asztalos
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Curr Opin Cardiol 19:385-91. 2004..The purpose of this review is to summarize the current understanding of the potentially antiatherogenic properties of high-density lipoprotein related to its different components... - Change in alpha1 HDL concentration predicts progression in coronary artery stenosisBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, Mass 02111, USA
Arterioscler Thromb Vasc Biol 23:847-52. 2003..We examined the effects of simvastatin-niacin and antioxidant vitamins on changes in high-density lipoprotein (HDL) subpopulations and alterations in coronary artery stenosis, as assessed by angiography... - Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese womenBela F Asztalos
Lipid Metabolism Laboratory, Human Nutrition Research Center at Tufts University, Boston, MA, USA
J Lipid Res 51:2405-12. 2010..05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients... - Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiencyBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Lipid Res 45:448-55. 2004.... - HDL in atherosclerosis: actor or bystander?Bela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
Atheroscler Suppl 4:21-9. 2003..The cholesterol in HDL can either be transferred to apolipoprotein B-containing particles via CETP or delivered directly to the liver with the help of scavenger receptor B1... - High-density lipoprotein particles, coronary heart disease, and niacinBela F Asztalos
Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Clin Lipidol 4:405-10. 2010..Based on the Framingham Heart Study data, HDL-C <35 mg/dl was established an independent risk factor and HDL-C >60 mg/dl as protective.(3) Presently the cut point is <40 mg/dl for men and <50 mg/dl for women... - Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levelsSeiko Otokozawa
Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University and Tufts University School of Medicine, Boston, MA 02111, USA
Atherosclerosis 205:197-201. 2009..Our findings utilizing a specific immunoassay and a fairly large number of subjects extend prior studies indicating that statins significantly lower apolipoprotein B containing lipoproteins of both intestinal and liver origin... - Effects of estrogen and medroxyprogesterone acetate on subpopulations of triglyceride-rich lipoproteins and high-density lipoproteinsStefania Lamon-Fava
Lipid Metabolism Laboratory and the Biostatistics Unit, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Metabolism 52:1330-6. 2003.... - Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levelsMasumi Ai
Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts, USA
Am J Cardiol 101:315-8. 2008.... - Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolismMargaret E Brousseau
Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA, USA
J Lipid Res 50:1456-62. 2009..Our findings indicate that CETP inhibition increases plasma concentrations of apoA-II by delaying HDL apoA-II catabolism and significantly alters the remodeling of apoA-II-containing HDL subpopulations... - Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjectsSeiko Otokozawa
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Metabolism 58:1536-42. 2009..Median apo B-48 values in healthy subjects are about 0.5 mg/dL and increase more than 100% in the fed state. Elevated levels are observed in obese and hyperlipidemic subjects... - Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivoFrank M Sacks
Harvard School of Public Health and Harvard Medical School, Boston, MA, USA, USA
J Lipid Res 50:894-907. 2009..Treatment with delipidated plasma tended to reduce diet-induced aortic atherosclerosis in monkeys measured by intravascular ultrasound. These findings link the conversion of small to large HDL, in vivo, to improvement in atherosclerosis... - Changes in remnant and high-density lipoproteins associated with hormone therapy and progression of coronary artery disease in postmenopausal womenStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
Atherosclerosis 205:325-30. 2009.... - Effect of hormone replacement therapy on plasma lipoprotein levels and coronary atherosclerosis progression in postmenopausal women according to type 2 diabetes mellitus statusStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Metabolism 59:1794-800. 2010..Faster progression of coronary atherosclerosis in women with diabetes could be mediated in part by a worse lipoprotein profile in these women than in women without diabetes, both before and during HRT... - Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteinsStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 28:1672-8. 2008..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear... - Marked HDL deficiency and premature coronary heart diseaseErnst J Schaefer
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Curr Opin Lipidol 21:289-97. 2010..Our purpose is to review recent publications in the area of marked human HDL deficiency, HDL particles, coronary heart disease (CHD), amyloidosis, the immune response, and kidney disease... - Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal womenStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 28:575-9. 2008..The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women... - Increasing high-density lipoprotein cholesterol, inhibition of cholesteryl ester transfer protein, and heart disease risk reductionErnst J Schaefer
Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
Am J Cardiol 100:n25-31. 2007..Another alternative for increasing HDL levels is to develop more effective and better tolerated niacin preparations... - High-density lipoprotein subpopulations in pathologic conditionsBela F Asztalos
Atherosclerosis Research Laboratory, New England Medical Center, Boston, Massachusetts, USA
Am J Cardiol 91:12E-17E. 2003..A new statin, rosuvastatin, produces greater increases in HDL cholesterol than atorvastatin, but its effect on HDL particle distribution is yet to be determined... - Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretionMargaret E Brousseau
Lipid Metabolism Laboratory, JM USDA HNRCA at Tufts University and Tufts New England Medical Center, Boston, Mass 02111, USA
Arterioscler Thromb Vasc Biol 25:1057-64. 2005..The present study was designed to address these issues... - Effects of atorvastatin on the HDL subpopulation profile of coronary heart disease patientsBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 43:1701-7. 2002.... - Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjectsErnst J Schaefer
Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA
Am J Cardiol 95:1025-32. 2005.... - The effects of statins on high-density lipoproteinsErnst J Schaefer
Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
Curr Atheroscler Rep 8:41-9. 2006.... - Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reductionErnst J Schaefer
Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts, USA
Curr Opin Lipidol 17:394-8. 2006.... - Should we target HDL-cholesterol to reduce coronary heart disease risk?Ernst J Schaefer
Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
Nat Clin Pract Endocrinol Metab 2:358-9. 2006 - Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolismStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 48:1746-53. 2007..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation... - Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction?Ernst J Schaefer
Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
Curr Opin Cardiol 22:373-8. 2007..To review recent research in the area of high-density lipoprotein raising and coronary heart disease risk reduction... - Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol effluxBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
J Infect Dis 202:614-23. 2010..These results indicate that SIV infection is a significant contributor to primary dyslipidemia, likely through the ability of Nef to suppress ABCA1-dependent reverse cholesterol transport... - Apolipoprotein A-I, B-100, and B-48 metabolism in subjects with chronic kidney disease, obesity, and the metabolic syndromeMarcelo C Batista
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Metabolism 53:1255-61. 2004.... - Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring StudyMasumi Ai
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Chem 56:967-76. 2010..We sought to establish reference values for a new direct assay for small dense LDL cholesterol (sdLDL-C) and to measure sdLDL-C concentrations in patients with established coronary heart disease (CHD) vs controls... - Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal womenStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Endocrinol (Oxf) 72:169-75. 2010..Subjects Postmenopausal Caucasian women (n = 208) participating in a placebo-controlled randomized trial of 3.2 years of hormone therapy (HT)... - Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitusMasumi Ai
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Chim Acta 406:71-4. 2009.... - SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndromePatricia G Yancey
Division of Gastroenterology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Lipid Res 45:1724-32. 2004..0 +/- 0.6%) and was positively correlated with prebeta-1 HDL. These studies demonstrated that prebeta-1 HDL is the preferred acceptor for ABCA1 efflux, whereas many particles mediate SR-BI efflux... - Cardiovascular events with increased lipoprotein-associated phospholipase A(2) and low high-density lipoprotein-cholesterol: the Veterans Affairs HDL Intervention TrialSander J Robins
Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA
Arterioscler Thromb Vasc Biol 28:1172-8. 2008..We sought to determine whether increased Lp-PLA(2) would also predict CV events in the absence of high LDL-cholesterol (LDL-C), in a population with low high-density lipoprotein-cholesterol (HDL-C)... - Remodeling of HDL remnants generated by scavenger receptor class B type INancy R Webb
Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
J Lipid Res 45:1666-73. 2004..We conclude that HDL remnants, generated by SR-BI, are converted to larger particles by rapidly reassociating with existing HDL particles in an enzyme-independent manner... - Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiencyRaul D Santos
Lipid Clinic and Lipid Metabolism Laboratory, Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
J Lipid Res 49:349-57. 2008....
Research Grants
- HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASEBela Asztalos; Fiscal Year: 2003..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..