Research Topics
Species | F E LundSummaryAffiliation: Trudeau Institute Country: USA Publications
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Publications
CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-riboseF E Lund
DNAX Research Institute, Palo Alto, CA 94304, USA
J Immunol 162:2693-702. 1999..Instead, we propose that CD38 signaling and coreceptor activity in vitro are regulated by conformational changes induced in the extracellular domain upon ligand/substrate binding, rather than on actual turnover or generation of products...- Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunityFrances E Lund
Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
Mol Med 12:328-33. 2006..Thus, immunity is regulated by CD38 in multiple and unexpected ways and the new research challenge will be to determine whether we can exploit the complex biology of CD38 to therapeutically regulate the immune system... - Regulatory roles for cytokine-producing B cells in infection and autoimmune diseaseFrances E Lund
Trudeau Institute, Saranac Lake, NY 12983, USA
Curr Dir Autoimmun 8:25-54. 2005.... - Cytokine-producing B lymphocytes-key regulators of immunityFrances E Lund
Trudeau Institute, Saranac Lake, NY 12983, USA
Curr Opin Immunol 20:332-8. 2008.... - CD38: a new paradigm in lymphocyte activation and signal transductionF E Lund
Trudeau Institute, Saranac Lake, New York 12983, USA
Immunol Rev 161:79-93. 1998..We suggest that signaling through CD38 represents a new paradigm in lymphocyte signal transduction and is predicated upon extracellular, rather than intracellular, crosstalk... - Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responsesD A Cockayne
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
Blood 92:1324-33. 1998..These data suggest that CD38 may play an important role in vivo in regulating humoral immune responses... - Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivoS Partida-Sanchez
Trudeau Institute, Saranac Lake, New York, USA
Nat Med 7:1209-16. 2001..Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants through its production of cyclic ADP-ribose, and acts as a critical regulator of inflammation and innate immune responses... - Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cellsF E Lund
DNAX Research Institute, Palo Alto, CA 94304, USA
Eur J Immunol 25:1338-45. 1995.... - Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38N Harada
DNAX Research Institute, Palo Alto, CA 94304
J Immunol 151:3111-8. 1993..We anticipate that the availability of probes for the murine B cell activation marker recognized by NIM-R5, and the recombinant protein itself, will greatly aid efforts to define the role of this molecule in murine B cell development... - CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transductionL Santos-Argumedo
DNAX Research Institute, Palo Alto, CA 94304, USA
Int Immunol 7:163-70. 1995.... - CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteinsChristian Krebs
Institute of Immunology, University Hospital, Hamburg, Germany
J Immunol 174:3298-305. 2005.... - Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptorDavid P Harris
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 174:6781-90. 2005.... - Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cellsDavid P Harris
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 175:7103-7. 2005.... - B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infectionFrances E Lund
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 176:6147-54. 2006..These data indicate that B cells play a vital role in generation of CD4(+) memory T cells in response to PC infection in the lungs... - CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanismFrances E Lund
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
Int Immunol 18:1029-42. 2006..Thus, the receptor-mediated functions of CD38 can be separated from its enzyme activity in a murine leukemic cell line, suggesting that CD38 plays multiple, but independent, biologic roles... - Suppressed insulin signaling and increased apoptosis in CD38-null isletsJames D Johnson
Division of Metabolism, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 55:2737-46. 2006..Thus, our results suggest that CD38 plays a role in novel antiapoptotic signaling pathways but does not directly control glucose signaling in pancreatic beta-cells... - Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reactionSantiago Partida-Sanchez
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 179:7827-39. 2007.... - Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytesGuixiu Shi
Trudeau Institute, Saranac Lake, NY 12983, USA
J Exp Med 204:2705-18. 2007.... - Altered airway responsiveness in CD38-deficient miceDeepak A Deshpande
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
Am J Respir Cell Mol Biol 32:149-56. 2005..The results of the present study demonstrate that CD38/cADPR contributes to airway smooth muscle tone and responsiveness through its effects on agonist-induced elevation of intracellular calcium in ASM cells... - CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responsesByung O Lee
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 171:5707-17. 2003.... - CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytesMiguel E Moreno-Garcia
Departamentos de Biología Celular Biomedicina Molecular, CINVESTAV IPN, Mexico
Eur J Biochem 271:1025-34. 2004.... - Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunitySantiago Partida-Sanchez
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
Immunity 20:279-91. 2004..Therefore, CD38 regulates adaptive immunity by controlling chemokine receptor signaling in DCs... - Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cellsIn-Jeong Kim
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 171:886-92. 2003..These data directly demonstrate viral exploitation of the normal B cell differentiation pathway to maintain latency... - Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenzaFrances E Lund
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 169:5236-43. 2002..However, the presence of LTalpha and/or lymph nodes does accelerate the initiation of immune responses, which leads to protection from larger doses of virus... - Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13Tom Cupedo
Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
J Immunol 173:4889-96. 2004.... - Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9Liliana Busconi
Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 179:7397-405. 2007..These data indicate that autoreactive B cells, stimulated by a combination of BCR and TLR9 ligands, acquire functional properties that may contribute to the activation of additional cells involved in the autoimmune disease process... - Role of CD38 in TNF-alpha-induced airway hyperresponsivenessAlonso G P Guedes
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
Am J Physiol Lung Cell Mol Physiol 294:L290-9. 2008..The mechanisms involved in this remission remain to be determined... - B cells promote resistance to heterosubtypic strains of influenza via multiple mechanismsJavier Rangel-Moreno
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 180:454-63. 2008.... - Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibodyFrances E Lund
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 171:1423-30. 2003..carinii-specific IgG plays an important, but not critical, role in defense against P. carinii. Moreover, these data suggest that B cells also mediate host defense against P. carinii by facilitating CD4(+) T cell activation or expansion... - Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organsJuan E Moyron-Quiroz
Trudeau Institute, Saranac Lake, New York 12983, USA
Immunity 25:643-54. 2006..These data show that SLOs are dispensable for the maintenance of immunologic memory and directly demonstrate the utility of local tissues, such as iBALT, in secondary immune responses... - CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challengeAlonso G P Guedes
Department of Veterinary Clinicial Sciences, University of Minnesota, St Paul, MN 55108, USA
Am J Physiol Lung Cell Mol Physiol 291:L1286-93. 2006..The results indicate that CD38 contributes to airway hyperresponsiveness in lungs exposed to IL-13 at least partly by increasing airway smooth muscle reactivity to contractile agonists... - Localization of CD38 in murine B lymphocytes to plasma but not intracellular membranesMiguel E Moreno-Garcia
Departamento de Biomedicina Molecular, Centro de Investigacion y Estudios Avanzados del I P N, Apartado Postal 14 740, CP 07360 México D F, Mexico
Mol Immunol 42:703-11. 2005.... - Role of CD38 in myometrial Ca2+ transients: modulation by progesteroneMichael Thompson
Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Physiol Endocrinol Metab 287:E1142-8. 2004..We propose that the balance between cytokines and placental steroids regulates the expression of CD38 in vivo and cell responsiveness to oxytocin... - Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoniStephen P Goodrich
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
Biochemistry 44:11082-97. 2005..Alternatively, the function of NACE may be to catabolize extracellular NAD(+) to prevent its use by host enzymes that utilize this source of NAD(+) to facilitate immune responses... - Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasiteKatja Mohrs
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 175:5306-13. 2005..These findings have important implications for the design of vaccination strategies because it may be necessary to establish and maintain memory CD4(+) T cells at the potential future site of infection... - CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfectionByung O Lee
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 175:5827-38. 2005..These data demonstrate that T cell-independent influenza-specific Ab promotes the resolution of primary influenza infection and helps to prevent reinfection... - Methodologic advancements in the study of airway smooth muscleMichael I Kotlikoff
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Allergy Clin Immunol 114:S18-31. 2004.... - Decreased cADPR and increased NAD+ in the Cd38-/- mouseGenevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ont, Canada N1G 3W1
Biochem Biophys Res Commun 346:188-92. 2006..We also report significant increases in brain, lung, and kidney NAD(+) in the Cd38(-/-) mouse, and provide the first experimental demonstration of the proximate relationship between CD38 and NAD(+)... - NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cellsSandra Soares
Department of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Physiol Cell Physiol 292:C227-39. 2007..Furthermore, the NAADP mediated mechanism in mammalian cells can be independent of RyRs and CD38. Our data provides novel insights into the understanding of the mechanism of action and metabolism of this new second messenger system... - Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infectionShabaana A Khader
Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
J Exp Med 203:1805-15. 2006..These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs... - Dual role of CD38 in microglial activation and activation-induced cell deathLior Mayo
Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
J Immunol 181:92-103. 2008..Our results thus suggest that CD38 significantly affects regulation of the amount and function of activated microglia, with important consequences for injury and repair processes in the brain...
Research Grants
- Generation and maintenance of influenza-specific plasma and memory B cellsFrances Lund; Fiscal Year: 2007..The experiments in this grant will identify the ways in which B cells contribute to immunity to influenza infection and will facilitate the design of more effective vaccines to this important human disease. ..
- NAD and CD38: modulators of inflammation and immunityFrances Lund; Fiscal Year: 2007..Thus, it is one of NIAID's highest priorities (NOT-AI-05-013) that we develop more effective influenza vaccines that are protective against a wide array of different viral serotypes. ..