Research Topics
Species | Mathew ThakurSummaryAffiliation: Thomas Jefferson University Country: USA Publications
Research Grants
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Detail Information
Publications
Targeting apoptosis for optical imaging of infectionMathew L Thakur
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Mol Imaging Biol 14:163-71. 2012..Targeting PS with intravenous administration of a PS-specific, near-infrared (NIR) fluorophore will permit localization of infectious foci by optical imaging...- Genomic biomarkers for molecular imaging: predicting the futureMathew L Thakur
Laboratories of Radiopharmaceutical Research and Molecular Imaging, Department of Radiology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Semin Nucl Med 39:236-46. 2009..The article also outlines a few examples predicting other possible applications of targeting such specific probes not yet used... - Report of a summit on molecular imagingMathew Thakur
Department of Radiology, Division of Nuclear Medicine, Thomas Jefferson University Medical College, 1020 Locust St, Suite 359 JAH, Philadelphia, PA 19107, USA
AJR Am J Roentgenol 186:297-9. 2006 - Report of a summit on molecular imagingMathew Thakur
Department of Radiology, Division of Nuclear Medicine, Thomas Jefferson University Medical College, Philadelphia, PA 19107, USA
Radiology 236:753-5. 2005 - PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analogMathew L Thakur
Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Nucl Med 45:1381-9. 2004..The purpose of this study was to assess the feasibility of PET imaging of oncogene VPAC1 receptors overexpressed in human breast cancer cells... - Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic productsMathew L Thakur
Department of Radiology, Kimmel Cancer Center, Philadelphia, Pennsylvania, USA
J Nucl Med 51:106-11. 2010..The objective of this investigation was to determine the ability of 1 of the peptide analogs, (64)Cu-TP3805, to detect BC in MMTVneu mice using (18)F-FDG as a gold standard... - Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluationKaijun Zhang
Laboratory of Radiopharmaceuticals and Molecular Imaging, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 361 JAH, Philadelphia, PA 19107, USA
Regul Pept 144:91-100. 2007..Data demonstrate that these analogues are potent, have uncompromised biological activity and are worthy of further evaluation for accurate PET imaging of human breast cancers and in determining malignant and benign lesions... - PET imaging of EGFR expression in nude mice bearing MDA-MB-468, a human breast adenocarcinomaKayvan Sadri
Department of Radiology, Thomas Jefferson University, Philadelphia, Pennysylvania 19107, USA
Nucl Med Commun 32:563-9. 2011..EGFR overexpression has been observed in a subset of breast cancers. The purpose of this study was to evaluate 64Cu-labeled cetuximab as an imaging agent using MDA-MB-468 breast cancer cells... - PET imaging of VPAC1 expression in experimental and spontaneous prostate cancerKaijun Zhang
Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Nucl Med 49:112-21. 2008..All PC overexpresses VPAC1 receptors. This investigation evaluated a probe specific for a (64)Cu-labeled receptor for PET imaging of experimental human PC in athymic nude mice and spontaneously grown PC in transgenic mice... - Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic USBarry B Goldberg
Department of Radiology, Thomas Jefferson University Hospital, 7th Floor Main Bldg, 132 S 10th St, Philadelphia, PA 19107, USA
Radiology 230:727-34. 2004.... - Imaging oncogene expressionArchana Mukherjee
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Eur J Radiol 70:265-73. 2009..An overview of the investigations on oncogene expression imaging is given. Finally, the need for further improvement in antisense-based imaging agents and directions to improve oncogene mRNA targeting is stated... - Imaging oncogene expressionXiaobing Tian
Department of Biochemistry Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Ann N Y Acad Sci 1002:165-88. 2003..This result enables testing of Tc-99m-peptide-PNA probes to image gene expression in tumors... - PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu]chelator-peptide nucleic acid-IGF1 analog radiohybridization probesXiaobing Tian
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Nucl Med 48:1699-707. 2007..Therefore, we hypothesized that malignant breast masses could be imaged and quantitated externally by PET with a dual-specificity probe that targets both CCND1 mRNA and IGF1R... - Imaging thromboembolism with fibrin-avid 99mTc-peptide: evaluation in swineMohan R Aruva
Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Nucl Med 47:155-62. 2006..CONCLUSION: (99m)Tc-TP850 with its modest affinity (10(-9) mol/L), rapid blood clearance, and high DVT and PE uptake is a promising agent for imaging vascular thrombosis... - Role of lipid-soluble complexes in targeted tumor therapyMathew L Thakur
Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359JAH, Philadelphia, PA 19107, USA
J Nucl Med 44:1293-300. 2003..This study assessed the therapeutic significance of lipid-soluble compounds of (111)In, which passively diffuse through the cell membrane, bind to cytoplasmic components, and remain cell bound until decay... - Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolismGregory Bix
Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Natl Cancer Inst 98:1634-46. 2006..CONCLUSIONS: Our results provide support for the hypothesis that endorepellin is an effective antitumor vasculature agent that could be used as a therapeutic modality to combat cancer... - Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimeraXiaobing Tian
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Bioconjug Chem 16:70-9. 2005..Molecular imaging of oncogene mRNAs in solid tumors with radiolabel-PNA-peptide chimeras might provide additional genetic characterization of preinvasive and invasive breast cancers... - Radionuclide-peptide nucleic acid in diagnosis and treatment of pancreatic cancerEric Wickstrom
Department of Biochemistry, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Methods Mol Med 106:135-91. 2005 - VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastomaPhyllis R Wachsberger
Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Int J Radiat Oncol Biol Phys 67:1526-37. 2007.... - An antimetastatic role for decorin in breast cancerSilvia Goldoni
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Pathol 173:844-55. 2008..In contrast, AG879 failed to have any effect. Our data support a role for decorin as a powerful and effective therapeutic agent against breast cancer due to its inhibition of both primary tumor growth and metastatic spreading... - Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunityAdam E Snook
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South Tenth St, Philadelphia, PA 19107, USA
J Natl Cancer Inst 100:950-61. 2008..Here we defined the immunogenicity and antitumor efficacy of guanylyl cyclase C (GCC), a protein that is normally restricted to intestinal mucosa and universally expressed by metastatic colorectal cancer... - Recent trends in soft-tissue infection imagingNicholas Petruzzi
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Semin Nucl Med 39:115-23. 2009..Overall, imaging such an agent via SPECT/CT or PET/CT will pave the way for greater clinical reliability in the localization of infection... - External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimerasXiaobing Tian
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233 S. 10th Street, Suite 219, Philadelphia, PA 19107-5541, USA
Ann N Y Acad Sci 1059:106-44. 2005..External molecular imaging of oncogene mRNAs in solid tumors with radiolabel-PNA-peptide chimeras might in the future provide additional genetic characterization of pre-invasive and invasive breast cancers... - Apoptotic abscess imaging with 99mTc-HYNIC-rh-Annexin-VDavid L Penn
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Nucl Med Biol 37:29-34. 2010..02+/-0.16 and 0.72+/-0.17 %ID/g at 4 (P<or=.05) and 24 h (P<or=.01). (99m)Tc-HYNIC-AnxV represents a minimally invasive and promising agent to image and potentially distinguish between infectious and inflammatory abscesses... - Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activationDaniela G Seidler
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 281:26408-18. 2006..Furthermore, decorin induced apoptosis via activation of caspase-3. This could represent an additional mechanism whereby decorin might influence cell growth and survival... - External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimerasXiaobing Tian
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Nucl Med 45:2070-82. 2004..99m)Tc-chimeras were distributed normally in the kidneys, liver, tumors, and other tissues. CONCLUSION: Cancer gene activity can be detected from outside the body by probing with radionuclide-chelator-PNA-peptide chimeras... - Design of (Gd-DO3A)n-polydiamidopropanoyl-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agentsNariman V Amirkhanov
Laboratory of Nucleic Acids Chemistry, Institute of Chemical Biology and Fundamental Medicine, Philadelphia, PA 19107, USA
Biopolymers 89:1061-76. 2008..84 +/- 20.48 mM(-1) s(-1)) (P < 0.05). Higher generations of PDAP dendrimers with 32 or more Gd-DO3A residues attached to PNA-D(Cys-Ser-Lys-Cys) genetic imaging agents might provide greater contrast for more sensitive detection... - Joint SNM/RSNA Molecular Imaging Summit StatementMathew L Thakur
J Nucl Med 46:11N-13N, 42N. 2005 - Radiolabeled peptides in oncology: role in diagnosis and treatmentRonald E Weiner
Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington, Connecticut 06030 2804, USA
BioDrugs 19:145-63. 2005..Other peptides currently under investigation, some of which have shown promising results, include Rhenium-188 (188Re)-P2045 and 90Y-alpha(v)beta3 antagonist... - Thakur receives Cassen prize for researchMathew L Thakur
J Nucl Med 49:32N. 2008 - Radiolabeled peptides in the diagnosis and therapy of oncological diseasesRonald E Weiner
Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington 06030 2804, USA
Appl Radiat Isot 57:749-63. 2002..Octreotide and its analogues labeled with 111In, 90Y, 64Cu or 177Lu are under study for the treatment of patients with promising results...
Research Grants
- IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDEMathew Thakur; Fiscal Year: 2002..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..
- Improved Molecular Imaging with SPECTMathew Thakur; Fiscal Year: 2006..It also takes advantage of adapting existing clinical SPECT machines, rather than developing a dedicated small animal imaging system, which makes it much less expensive and more widely available. ..
- PET Imaging of Breast Cancer Using Oncogene ExpressionMathew Thakur; Fiscal Year: 2007..abstract_text> ..