Research Topics
Genomes and Genes | Sergio JimenezSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Biomarkers in systemic sclerosisSusan V Castro
Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107 15541, USA
Biomark Med 4:133-47. 2010..Thus, there is an unmet need for validated biomarkers for diagnosis, disease classification, and evaluation of organ involvement and therapeutic response in systemic sclerosis...- Dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy): study of inflammatory cells and transforming growth factor beta1 expression in affected skinSergio A Jimenez
Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
Arthritis Rheum 50:2660-6. 2004..The aim of the present study was to describe the clinical and histopathologic features of 9 new cases and to characterize the inflammatory cells and expression of transforming growth factor beta1 (TGFbeta1) in affected skin... - Microchimerism and systemic sclerosisSergio A Jimenez
Thomas Jefferson University, Department of Medicine, Division of Rheumatology, Philadelphia, Pennsylvania 19107, USA
Curr Opin Rheumatol 17:86-90. 2005..This article reviews the published literature related to the possible role of microchimeric cells in the pathogenesis of systemic sclerosis... - Autoantibodies in patients with systemic sclerosis and cancer: a case-control studyChris T Derk
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 South 10th Street, 509 BLSB, Philadelphia, PA 19107, USA
J Rheumatol 30:1994-6. 2003..To determine the prevalence of specific autoantibodies in a cohort of patients with systemic sclerosis (SSc) and a diagnosis of cancer, and to compare it to that in a group of patients with SSc who were never diagnosed with cancer... - Increased incidence of carcinoma of the tongue in patients with systemic sclerosisChris T Derk
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Rheumatol 32:637-41. 2005..To describe the incidence of carcinoma of the tongue in a large cohort of patients with systemic sclerosis (SSc)... - Morbidity and mortality of patients diagnosed with systemic sclerosis after the age of 75: a nested case-control studyChris T Derk
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19017, USA
Clin Rheumatol 25:831-4. 2006..A higher clinical suspicion will lead to an earlier diagnosis and a potential decrease in morbidity and mortality... - Acute myocardial infarction in systemic sclerosis patients: a case seriesChris T Derk
Division of Rheumatology, Thomas Jefferson University, 613 Curtis Bldg, 1015 Walnut Street, Philadelphia, PA 19107 5541, USA
Clin Rheumatol 26:965-8. 2007..Normal coronaries are seen more commonly in these patients as compared to the general population, while vascular, gastrointestinal, and renal involvement is prevalent in these patients... - A cohort study of cancer incidence in systemic sclerosisChris T Derk
Division of Rhematology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Rheumatol 33:1113-6. 2006..To describe the incidence of cancer in a large cohort of patients with systemic sclerosis (SSc) and compare it to the Surveillance Epidemiology and End Results (SEER) cancer registries... - Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents?Chris T Derk
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 613 Curtis Bldg, 1015 Walnut Street, Philadelphia, PA 19107 5541, USA
Autoimmun Rev 5:25-32. 2006..Here, we review the current literature, which suggests that statins may have a modifying effect on the vasculopathy of systemic sclerosis... - Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblastsFederica Sotgia
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
Am J Pathol 174:746-61. 2009..Thus, these results have important implications for understanding the role of cancer-associated fibroblasts and RB inactivation in promoting tumor angiogenesis... - Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritisJorge A Roman-Blas
Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA
Int Rev Immunol 27:351-74. 2008..In addition, promising nucleic acid-based strategies have shown encouraging results. However, further research will be needed before NF-kappaB-aimed strategies become an effective therapy for inflammatory arthritis... - Thermostability gradient in the collagen triple helix reveals its multi-domain structureAndrzej Steplewski
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Mol Biol 338:989-98. 2004.... - Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cellsJagmohan Singh
Department of Medicine, Thomas Jefferson Univ, Philadelphia, PA 19107, USA
Am J Physiol Gastrointest Liver Physiol 297:G1206-13. 2009..These data suggest that SSc GI dysmotility may be caused by autoantibodies that inhibit the muscarinic neurotransmission. Future treatment of SSc patients may be directed at the removal or neutralization of these antibodies... - NF?B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosisFrancesco Del Galdo
Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Ann Rheum Dis 69:2024-33. 2010..To elucidate the mechanisms responsible for macrophage activation, the effects of the GdBCA Omniscan on normal human macrophage global gene expression, chemokine production and nuclear factor ?B (NF?B) activation was examined... - Systemic sclerosis: current views of its pathogenesisChris T Derk
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Autoimmun Rev 2:181-91. 2003..A better understanding of the pathogenesis of this incurable disorder will help to better target and design effective therapy in the future... - B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblastsLucia Cicchillitti
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Biochem J 378:609-16. 2004..Thus these results suggest that B-Myb may be an important factor in the pathway(s) regulating collagen production in SSc fibroblasts... - Significance of ground-glass opacity on HRCT in long-term follow-up of patients with systemic sclerosisRosita M Shah
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
J Thorac Imaging 22:120-4. 2007..In systemic sclerosis, ground-glass opacity is most commonly associated with irreversible disease. Disease progression or improvement could not be predicted by the presence of ground-glass opacity... - Murine animal models of systemic sclerosisSergio A Jimenez
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Curr Opin Rheumatol 14:671-80. 2002..The prudent interpretation of the results obtained from the study of animal models has provided substantial and valuable information about the pathogenesis of the human disease... - Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosisFrancesco Del Galdo
Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107 5541, USA
Curr Opin Rheumatol 20:713-9. 2008.... - Demonstration of autoimmunity in the tight skin-2 mouse: a model for sclerodermaJulieta Gentiletti
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 175:2418-26. 2005.... - Oligoclonal T cell expansion in the skin of patients with systemic sclerosisLazaros I Sakkas
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Immunol 168:3649-59. 2002..These results suggest that T cells are involved in the pathogenesis of the disease... - Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743Natalia Louneva
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 278:40400-7. 2003.... - Scleroderma fibroblast survival in AktionNora Sandorfi
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Invest Dermatol 124:viii-xi. 2005 - Improvement of severe systemic sclerosis-associated gastric antral vascular ectasia following immunosuppressive treatment with intravenous cyclophosphamideSteffan W Schulz
Jefferson Institute of Molecular Medicine, Division of Connective Tissue Disease, Department of Dermatology and CutaneousBiology, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania and Division of Rheumatology, Lehigh ValleyHospital, Allentown, Pennsylvania, USA
J Rheumatol 36:1653-6. 2009.... - Persistent activation of dermal fibroblasts from patients with gadolinium-associated nephrogenic systemic fibrosisSonsoles Piera-Velazquez
Department of Dermatology and Cutaneous Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Ann Rheum Dis 69:2017-23. 2010..Nephrogenic systemic fibrosis (NSF) is a systemic fibrotic disorder occurring in some patients with renal insufficiency after exposure to gadolinium-based contrast agents (GdBCA)... - Primary B-cell lymphoma of the tongue in a patient with systemic sclerosisChris T Derk
Division of Rheumatology, Thomas Jefferson University, 613 Curtis Bldg, 1015 Walnut Street, Philadelphia, PA 19107, USA
Oral Oncol 40:103-6. 2004..A careful review of the English medical literature disclosed that B-cell lymphoma of the tongue in a patient with systemic sclerosis is an association which has not been described previously... - Increased microchimeric CD4+ T lymphocytes in peripheral blood from women with systemic sclerosisCarol M Artlett
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Room 509, Bluemle Lifesciences Building, 233 South 10th Street, Philadelphia, Pennsylvania 19107 5541, USA
Clin Immunol 103:303-8. 2002..These results support the hypothesis that microchimeric CD4+ T cells may be involved in the pathogenesis of SSc... - Position of single amino acid substitutions in the collagen triple helix determines their effect on structure of collagen fibrilsAndrzej Steplewski
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Struct Biol 148:326-37. 2004..These results provide a basis for identifying pathways leading from single amino acid substitutions in collagen II to changes in the structure of individual fibrils and in the organization of collagenous matrices... - Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approachesPaul J Christner
Division of Rheumatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Curr Opin Rheumatol 16:746-52. 2004.... - The role of allograft inflammatory factor 1 in systemic sclerosisFrancesco Del Galdo
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Curr Opin Rheumatol 18:588-93. 2006.... - Maternal mixed connective tissue disease and offspring with chondrodysplasia punctataSteffan W Schulz
Division of Rheumatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Semin Arthritis Rheum 39:410-6. 2010.... - Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9Ping Zhang
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 278:117-23. 2003..DNA-protein binding assays and super-shift analysis revealed that SOX9 can form a specific complex with one of the SOX/Sry-binding sites with in the -560 to +130 region... - Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomeraseSonsoles Piera-Velazquez
Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541, USA
Arthritis Rheum 46:683-93. 2002..These cells have the potential to be used for restoration of the articular cartilage defects occurring in this disease... - Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosisSergio A Jimenez
Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541, USA
Ann Intern Med 140:37-50. 2004 - Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytesIbsen B Coimbra
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA 19107-5541, USA
Osteoarthritis Cartilage 12:336-45. 2004..Modulation of HIF-1alpha levels by TNF-alpha may have important implications for chondrocyte metabolism during degenerative joint disease. In addition, we detected for the first time the expression of HIF-2alpha mRNA in chondrocytes... - Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literatureChris T Derk
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
J Rheumatol 30:1616-20. 2003..We review the cases reported to date in the literature and describe the clinical characteristics, therapy, and outcome of this group of patients... - A role for the androgen receptor in collagen content of the skinMarina S Markova
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Invest Dermatol 123:1052-6. 2004..These findings demonstrate that there are striking differences in the collagen content of skin between male and female mice, and provide a biochemical explanation for these differences... - Impaired rectoanal inhibitory response in scleroderma (systemic sclerosis): an association with fecal incontinenceGregory J Heyt
Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jeffereson University Hospital, Philadelphia, Pennsylvania, USA
Dig Dis Sci 49:1040-5. 2004..Impaired RAIR was closely correlated with fecal incontinence, suggesting a possible neural mechanism for maintenance of continence... - Detection of microchimeric cells in the peripheral blood of nonpregnant women is enhanced by magnetic cell sorting before PCRLori A Cox
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Clin Chem 49:309-12. 2003 - Involvement of skeletal muscle in dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy)Joshua M Levine
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Muscle Nerve 30:569-77. 2004..These results further support the contention that NFD is not a purely cutaneous disease, but is part of a larger systemic fibrotic process that may involve muscles... - Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblastsSergei P Atamas
Baltimore VA Medical Center, Research Service 151, Room 3C 125, 10 North Greene Street, Baltimore, MD 21201, USA
Am J Respir Cell Mol Biol 29:743-9. 2003..Inhibition experiments with pertussis toxin suggested that PARC receptor is G protein-coupled. Thus, PARC is a member of the CC chemokine family that acts directly as a profibrotic factor... - Case 35-2004: nephrogenic fibrosing dermopathyRobert A Taylor
N Engl J Med 352:1723-4; author reply 1723-4. 2005 - Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factorsMagdalini Kypriotou
Laboratoire de Biochimie du Tissu Conjonctif, Universite de Caen Basse Normandie, IFR ICORE 146, FacultédeMédecine, CHU niveau 3, Avenue de la Cote de Nacre, 14032 Caen Cedex, France
J Biol Chem 282:32000-14. 2007.... - Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literatureFabian A Mendoza
Department of Medicine, Temple University, Philadelphia, PA, USA
Semin Arthritis Rheum 35:238-49. 2006..CONCLUSIONS: NFD is a severe and usually progressive systemic fibrotic disease affecting the dermis, subcutaneous fascia, and striated muscles. It also appears that the disease can cause fibrosis of lungs, myocardium, and other organs...
Research Grants
- BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMASergio A Jimenez; Fiscal Year: 2010....
- BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMASergio Jimenez; Fiscal Year: 2004....
- COLLAGEN METABOLISM IN A MODEL FOR SCLERODERMASergio Jimenez; Fiscal Year: 2002....
- Molecular Biology of OsteoarthritisSergio Jimenez; Fiscal Year: 2006..abstract_text> ..
- TRAINING IN MOLECULAR RHEUMATOLOGY AND ORTHOPEDICSSergio Jimenez; Fiscal Year: 2007..D.'s capable of establishing independent research programs in areas relevant to Rheumatology and Orthopedics. ..
- Role of Caveolin in Scleroderma Tissue Fibrosis and VasculopathySergio A Jimenez; Fiscal Year: 2010....
- BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMASergio Jimenez; Fiscal Year: 2009....
- Role of Caveolin in Scleroderma Tissue Fibrosis and VasculopathySergio Jimenez; Fiscal Year: 2009....
- BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMASergio Jimenez; Fiscal Year: 2007....
- COLLAGEN METABOLISM IN A MODEL FOR SCLERODERMASergio Jimenez; Fiscal Year: 1992....
- BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMASergio Jimenez; Fiscal Year: 1999....
- COLLAGEN METABOLISM IN A MODEL FOR SCLERODERMASergio Jimenez; Fiscal Year: 1993....
- BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMASergio Jimenez; Fiscal Year: 1993..It is expected that this comprehensive approach will give further insight into the pathogenesis and possible treatment of this incurable disease...