CHARLES M BRENNER

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer
    Helen C Pace
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Genome Biol 4:R18. 2003
  2. ncbi Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins
    C Brenner
    Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA
    Nat Struct Biol 4:231-8. 1997
  3. ncbi A cultivated taste for yeast
    C Brenner
    Kimmel Cancer Center, Thomas Jefferson University, 233 South Tenth Street, Philadelphia, PA 19107, USA
    Genome Biol 1:REVIEWS103. 2000
  4. ncbi Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases
    Charles Brenner
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biochemistry 41:9003-14. 2002
  5. ncbi Catalysis in the nitrilase superfamily
    Charles Brenner
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Curr Opin Struct Biol 12:775-82. 2002
  6. ncbi Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding
    Francesco Trapasso
    Genetics and Molecular Biology Program, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 100:1592-7. 2003
  7. ncbi Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10852-60. 2002
  8. ncbi Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:33049-55. 2003
  9. ncbi Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors
    Agnieszka Krakowiak
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 279:18711-6. 2004
  10. ncbi The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:33056-9. 2003

Collaborators

  • Hideshi Ishii
  • G Michael Blackburn
  • Jeffrey L Benovic
  • Kay Huebner
  • G G Petsko
  • Pawel Bieganowski
  • Helen C Pace
  • Agnieszka Krakowiak
  • Shawn K Milano
  • Francesco Trapasso
  • You Me Kim
  • You-Me Kim
  • Frank P Stefano
  • Janina Baraniak
  • Abdelaziz Mekhalfia
  • Renata Kaczmarek
  • Wojciech J Stec
  • Martina Adams
  • Andrea Vecchione
  • Jeffrey Arkles
  • Tamotsu Kuroki
  • Rossano Cesari
  • Carlo M Croce
  • Sai Yendamuri
  • Santosh C Hodawadekar
  • Preston N Garrison
  • Gerard Faye
  • Larry D Barnes

Detail Information

Publications11

  1. ncbi Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer
    Helen C Pace
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Genome Biol 4:R18. 2003
    ..Genomic and expression data suggest that Asw may feminize chicks, dominantly interfering with Hint function by heterodimerization...
  2. ncbi Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins
    C Brenner
    Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA
    Nat Struct Biol 4:231-8. 1997
    ..Features of FHIT, a diadenosine polyphosphate hydrolase and candidate tumour suppressor, are predicted from HINT-nucleotide structures...
  3. ncbi A cultivated taste for yeast
    C Brenner
    Kimmel Cancer Center, Thomas Jefferson University, 233 South Tenth Street, Philadelphia, PA 19107, USA
    Genome Biol 1:REVIEWS103. 2000
    ....
  4. ncbi Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases
    Charles Brenner
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biochemistry 41:9003-14. 2002
    ....
  5. ncbi Catalysis in the nitrilase superfamily
    Charles Brenner
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Curr Opin Struct Biol 12:775-82. 2002
    ..Recent experimental results confirm the essentiality of the catalytic triad residues and specify the biochemical functions of additional branches and sub-branches of the nitrilase superfamily...
  6. ncbi Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding
    Francesco Trapasso
    Genetics and Molecular Biology Program, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 100:1592-7. 2003
    ..These data indicate that the proapoptotic function of Fhit is limited by substrate binding and is unrelated to substrate hydrolysis...
  7. ncbi Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10852-60. 2002
    ..Functional complementation of all Hnt1 phenotypes was provided by rabbit Hint, which is only 22% identical to yeast Hnt1 but has very similar adenosine monophosphoramidase activity...
  8. ncbi Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:33049-55. 2003
    ....
  9. ncbi Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors
    Agnieszka Krakowiak
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 279:18711-6. 2004
    ..Ser-107 is positioned to donate a hydrogen bond to the leaving group nitrogen. Consistent with a role in acid-base catalysis, the Hint S107A mutant protein displayed depressed catalytic activity...
  10. ncbi The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:33056-9. 2003
    ..Here we establish that the so-called NADsyn2 is simply ammonia-dependent NAD+ synthetase from Pseudomonas, which is encoded on an operon with nicotinic acid phosphoribosyltransferase and, in some Pseudomonads, with nicotinamidase...
  11. ncbi Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding
    Shawn K Milano
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:9812-23. 2006
    ..Thus, by promoting cytosolic oligomerization, IP(6) binding is proposed to be a negative regulator of interactions of arrestin with plasma membrane and nuclear signaling proteins...