Research Topics
| Carol M ArtlettSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Detail Information
Publications
Immunology of systemic sclerosisCarol M Artlett
Division of Rheumatology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Room 509 Philadelphia, PA 19107, USA
Front Biosci 10:1707-19. 2005..The interactions between blood vessels, fibroblast activity, and immunological processes play an important role in the pathogenesis of SSc...- Pathophysiology of fetal microchimeric cellsCarol M Artlett
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Clin Chim Acta 360:1-8. 2005..Much controversy exists around the role of microchimeric cells in the pathogenesis of certain diseases, and these cells in tissues may be a consequence rather than the cause of disease... - The role of allograft inflammatory factor 1 in systemic sclerosisFrancesco Del Galdo
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Curr Opin Rheumatol 18:588-93. 2006.... - Expression of allograft inflammatory factor 1 in tissues from patients with systemic sclerosis and in vitro differential expression of its isoforms in response to transforming growth factor betaFrancesco Del Galdo
Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Arthritis Rheum 54:2616-25. 2006..The purpose of this study was to investigate AIF-1 expression in affected tissues from patients with SSc and to examine the regulation of its isoforms by transforming growth factor beta (TGFbeta)... - 3-Deoxyglucosone-collagen alters human dermal fibroblast migration and adhesion: implications for impaired wound healing in patients with diabetesDanielle T Loughlin
Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
Wound Repair Regen 17:739-49. 2009..Furthermore, 3DG may be a factor mediating chronic wounds observed in patients with diabetes and in the elderly by altering the signaling within the fibroblast and inducing the misfolding of proteins... - Microchimerism and scleroderma: an updateCarol M Artlett
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Curr Rheumatol Rep 5:154-9. 2003.... - A cohort study of cancer incidence in systemic sclerosisChris T Derk
Division of Rhematology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Rheumatol 33:1113-6. 2006..To describe the incidence of cancer in a large cohort of patients with systemic sclerosis (SSc) and compare it to the Surveillance Epidemiology and End Results (SEER) cancer registries... - Demonstration of autoimmunity in the tight skin-2 mouse: a model for sclerodermaJulieta Gentiletti
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 175:2418-26. 2005.... - HLA-DQA1 is not an apparent risk factor for microchimerism in patients with various autoimmune diseases and in healthy individualsCarol M Artlett
Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Arthritis Rheum 48:2567-72. 2003..Furthermore, DQA1*0501 has been associated with T lymphocyte microchimerism in SSc. To better define the strength of this association, we assessed the relationship among DQA1 alleles and microchimerism... - Dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy): study of inflammatory cells and transforming growth factor beta1 expression in affected skinSergio A Jimenez
Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
Arthritis Rheum 50:2660-6. 2004..The aim of the present study was to describe the clinical and histopathologic features of 9 new cases and to characterize the inflammatory cells and expression of transforming growth factor beta1 (TGFbeta1) in affected skin... - Microchimerism in health and diseaseCarol M Artlett
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA
Curr Mol Med 2:525-35. 2002..And more recently, microchimeric cells have been implicated in the pathogenesis of autoimmune diseases including systemic sclerosis and myositis... - Microchimerism and systemic sclerosisSergio A Jimenez
Thomas Jefferson University, Department of Medicine, Division of Rheumatology, Philadelphia, Pennsylvania 19107, USA
Curr Opin Rheumatol 17:86-90. 2005..This article reviews the published literature related to the possible role of microchimeric cells in the pathogenesis of systemic sclerosis... - Two dicarbonyl compounds, 3-deoxyglucosone and methylglyoxal, differentially modulate dermal fibroblastsSihem Sassi-Gaha
Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
Matrix Biol 29:127-34. 2010.... - T cells and B cells in the pathogenesis of systemic sclerosis: recent insights and therapeutic opportunitiesFrancesco Del Galdo
Division of Rheumatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Curr Rheumatol Rep 8:123-30. 2006.... - IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responsesYvonne M Mueller
Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Immunol 180:350-60. 2008..Finally, IL-15-treated acutely SIV-infected primates may serve as a useful model to investigate the poorly understood mechanisms that control viral set point and disease progression in HIV infection... - Morbidity and mortality of patients diagnosed with systemic sclerosis after the age of 75: a nested case-control studyChris T Derk
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19017, USA
Clin Rheumatol 25:831-4. 2006..A higher clinical suspicion will lead to an earlier diagnosis and a potential decrease in morbidity and mortality... - Animal models of scleroderma: fresh insightsCarol M Artlett
Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
Curr Opin Rheumatol 22:677-82. 2010..However, even though these models provide useful insights into the pathogenesis of fibrosis and vasculopathy, they do not mimic the disease accurately... - Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literatureFabian A Mendoza
Department of Medicine, Temple University, Philadelphia, PA, USA
Semin Arthritis Rheum 35:238-49. 2006..CONCLUSIONS: NFD is a severe and usually progressive systemic fibrotic disease affecting the dermis, subcutaneous fascia, and striated muscles. It also appears that the disease can cause fibrosis of lungs, myocardium, and other organs... - The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosisCarol M Artlett
Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
Arthritis Rheum 63:3563-74. 2011..This study was undertaken to assess the role of the inflammasome in SSc-related dermal or pulmonary fibrosis... - Oligoclonal T cell expansion in the skin of patients with systemic sclerosisLazaros I Sakkas
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Immunol 168:3649-59. 2002..These results suggest that T cells are involved in the pathogenesis of the disease... - Increased microchimeric CD4+ T lymphocytes in peripheral blood from women with systemic sclerosisCarol M Artlett
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Room 509, Bluemle Lifesciences Building, 233 South 10th Street, Philadelphia, Pennsylvania 19107 5541, USA
Clin Immunol 103:303-8. 2002..These results support the hypothesis that microchimeric CD4+ T cells may be involved in the pathogenesis of SSc... - Chronic graft-versus-host-disease-like dermopathy in a child with CD4+ cell microchimerismLutz Kowalzick
Department of Dermatology and Allergology, HUMAINE Vogtland Klinikum Plauen, Plauen, Germany
Dermatology 210:68-71. 2005..A distinct improvement of erythemas and sclerosis could be achieved by means of low-dose UVA1 phototherapy which was applied with escalating single doses of 3-12 J/cm2 for 35 consecutive days...