Research Topics
Genomes and GenesSpecies | B ZurawSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Detail Information
Publications
Novel therapies for hereditary angioedemaBruce L Zuraw
University of California San Diego, La Jolla, CA 92093 0732, USA
Immunol Allergy Clin North Am 26:691-708. 2006..This article reviews the rationale, development, and potential use of these novel therapeutics...- Diagnosis and management of hereditary angioedema: an American approachBruce L Zuraw
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA
Transfus Apher Sci 29:239-45. 2003..Areas in which the diagnostic or therapeutic tools are deficient are discussed, and the prospects for improved therapeutic modalities highlighted... - Current and future therapy for hereditary angioedemaBruce L Zuraw
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Clin Immunol 114:10-6. 2005..This article will review both the current and the future therapeutic options for the treatment of HAE... - Endothelin-1 (ET-1) decreases human bronchial epithelial cell migration and proliferation: implications for airway remodeling in asthmaA Dosanjh
Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Asthma 40:883-6. 2003..The presence of ET-1 results in slower migration of epithelial cells compared to control (p < 0.04). Based on these in vitro findings, ET-1 could potentially lead to inhibition of repair of the lung epithelium and enhanced remodeling... - Hereditary angiodema: a current state-of-the-art review, IV: short- and long-term treatment of hereditary angioedema: out with the old and in with the new?Bruce L Zuraw
Veterans Affairs Medical Center, San Diego, California, USA
Ann Allergy Asthma Immunol 100:S13-8. 2008..To provide a context to understand the opportunity for novel therapeutic modalities to transform the treatment of hereditary angioedema (HAE)... - Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c releaseIchiro Kuwabara
Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Biol Chem 277:3487-97. 2002..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3... - Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitisJane Eddleston
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif 92037, USA
J Allergy Clin Immunol 111:106-12. 2003..CONCLUSION: This study demonstrates the in vivo regulation of chemokine receptors by means of bradykinin in human airway tissue in patients with allergic rhinitis... - Up-regulation of functional kinin B1 receptors in allergic airway inflammationSandra C Christiansen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:2054-60. 2002..Taken together, these results show that functional B1 receptors are induced in the airway during allergic inflammation and suggest that they participate in the regulation of gene expression... - Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediatorsJane Eddleston
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:6445-51. 2002..This may lead to enhanced activation of intracellular signaling pathways resulting in the release of mediators involved in inflammatory allergic airway disease... - Serving the underserved: school-based asthma intervention programsSandra C Christiansen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Asthma 39:463-72. 2002..Strategies are required that can specifically address the needs of underserved communities. We review the underlying rationale and progress of school-based programs designed to assist asthmatic children... - Health care consumption among elderly patients in california: a comprehensive 10-year evaluation of trends in hospitalization rates and chargesJames A Koziol
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Gerontologist 42:207-16. 2002..An improved understanding of current trends in health care consumption would facilitate the development of future resource allocation models... - New promise and hope for treating hereditary angioedemaBruce L Zuraw
Veterans Medical Research Foundation, University of California San Diego, La Jolla, CA 92093 0732, USA
Expert Opin Investig Drugs 17:697-706. 2008..While there is no approved effective therapy for the treatment of acute attacks of hereditary angioedema in the USA, four different drugs are completing or have recently completed Phase III clinical trials... - The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cellsJane Eddleston
Veterans Medical Research Foundation, La Jolla, CA, USA
J Allergy Clin Immunol 119:115-22. 2007..A recently described anti-inflammatory protein, glucocorticoid-induced leucine zipper (GILZ), interferes with NF-kappaB-mediated gene transcription in T cells and macrophages... - Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytesLing Yu Chen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla 92037, California 92121, USA
Am J Physiol Lung Cell Mol Physiol 284:L607-13. 2003..These findings provide evidence that LPS-induced NF-kappaB activation and IL-8 gene expression use a signaling pathway requiring protein tyrosine kinase and that such regulation may occur through tyrosine phosphorylation of TLR4... - International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequencesL M Fredrik Leeb-Lundberg
Division of Cellular and Molecular Pharmacology, Department of Experimental Medical Science, Lund University, BMC, A12, SE 22184 Lund, Sweden
Pharmacol Rev 57:27-77. 2005..This review is a comprehensive presentation of our current understanding of these receptors in terms of molecular and cell biology, physiology, pharmacology, and involvement in human disease and drug development... - IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcriptionLing Yu Chen
Department of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:3934-9. 2002..These results indicate that RhoA and IL-1R-associated kinase are novel signal transducers for LPS-induced Toll-like receptor 4-mediated proinflammatory cytokine synthesis in human monocytes... - Clinical practice. Hereditary angioedemaBruce L Zuraw
University of California at San Diego and the Veterans Affairs Medical Center, San Diego, USA
N Engl J Med 359:1027-36. 2008