Research Topics
Genomes and Genes | Li ZhangSummaryAffiliation: The University of Texas Country: USA Publications
| Collaborators
|
Detail Information
Publications
Large scale analysis of positional effects of single-base mismatches on microarray gene expression dataFenghai Duan
Center for Statistical Sciences, Brown University, Providence, RI, USA
BioData Min 3:2. 2010..Previous research has indicated that binding between probes and targets strongly depends on the positions of these mismatches. However, there has been substantial variability in the effect of mismatch type across studies...- Serial dilution curve: a new method for analysis of reverse phase protein array dataLi Zhang
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1410, Houston, TX 77030, USA
Bioinformatics 25:650-4. 2009..AVAILABILITY: A computer program in R for using serial dilution curve for RPPA data analysis is freely available at http://odin.mdacc.tmc.edu/~zhangli/RPPA... - Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokersLi Zhang
Department of Bioinformatics The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Prev Res (Phila) 1:112-8. 2008.... - Free energy of DNA duplex formation on short oligonucleotide microarraysLi Zhang
Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 237, Houston, TX 77030, USA
Nucleic Acids Res 35:e18. 2007..These results provide important insights into the molecular mechanisms of microarray technology and have implications for microarray design and the interpretation of observed data... - A model of molecular interactions on short oligonucleotide microarraysLi Zhang
Department of Biostatistics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd 447, Houston, Texas 77030, USA
Nat Biotechnol 21:818-21. 2003..The model indicates that the amount of nonspecific binding can be estimated from a simple rule. Using this model, we have developed an improved measure of gene expression for use in data analysis... - Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancerLanlan Shen
Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030
Proc Natl Acad Sci U S A 104:18654-9. 2007..Together, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease... - Biomarkers of response to preoperative chemoradiation in esophageal cancersRajyalakshmi Luthra
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
Semin Oncol 33:S2-5. 2006.... - Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancersMadan G Luthra
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
Clin Cancer Res 13:912-9. 2007..In the current study, we did an in-depth investigation of the expression of 1q21-1q25 region genes to uncover the role of the EDC and its flanking genes in CTXRT response... - A multigene predictor of outcome in glioblastomaHoward Colman
Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77401, USA
Neuro Oncol 12:49-57. 2010..The profile has potential clinical application both for optimization of therapy in GBM and for the identification of novel therapies targeting tumors refractory to standard therapy... - Dicer ablation impairs prostate stem cell activity and causes prostate atrophyLi Zhang
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Stem Cells 28:1260-9. 2010..Our results demonstrate a critical role of microRNAs for the proliferative capacity of prostate stem cells and the maintenance of prostate homeostasis... - Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastomaChristopher E Pelloski
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 25:2288-94. 2007..We sought to evaluate the clinical significance of GBM subtypes as defined by EGFRvIII status... - Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promotersLanlan Shen
Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
PLoS Genet 3:2023-36. 2007.... - Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targetsLin Yang
Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 283:35295-304. 2008..We also demonstrate vascular endothelial growth factor as a direct ZKSCAN3 target. Thus, ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4... - Gene expression profiling predicts the development of oral cancerPierre Saintigny
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer Prev Res (Phila) 4:218-29. 2011..Our results show that gene expression profiles may improve the prediction of oral cancer risk in OPL patients and the significant genes identified may serve as potential targets for oral cancer chemoprevention... - Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapseHeike Kroeger
Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Blood 112:1366-73. 2008..0% to 15.2% (median 10.6%) genes in relapse (P < .001). Our data suggest that DNA methylation is involved in AML progression and provide a rationale for the use of epigenetic agents in remission maintenance... - Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3Hiroshi Aoki
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Autophagy 4:467-75. 2008..Anti-LC3B antibody provides a useful tool for monitoring the induction of autophagy in cancer cells and tissues... - Sequence dependence of cross-hybridization on short oligo microarraysChunlei Wu
Department of Biostatistics and Applied Mathematics, The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd-447, Houston, TX 77030, USA
Nucleic Acids Res 33:e84. 2005..Our results also showed that the oligo fragments tend to bind to the 5' ends of the probes, and are rarely seen at the 3' ends. These results are useful for microarray design and data analysis... - Extracting three-way gene interactions from microarray dataJiexin Zhang
Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 237, Houston, TX 77030 4009, USA
Bioinformatics 23:2903-9. 2007..The identified three-way interactions may constitute candidates for further experimentation using techniques such as RNA interference, so that novel gene network or pathways could be identified... - Widespread and tissue specific age-related DNA methylation changes in miceShinji Maegawa
Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genome Res 20:332-40. 2010..We conclude that epigenetic deregulation is a common feature of aging in mammals... - The rapamycin-regulated gene expression signature determines prognosis for breast cancerArgun Akcakanat
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cancer 8:75. 2009..In this study, we tested the hypothesis that the gene-expression signature regulated by rapamycin could predict disease outcome for patients with breast cancer... - Epigenomic profiling indicates a role for DNA methylation in early postnatal liver developmentRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, 1100 Bates St, Ste 5080, Houston, TX 77030, USA
Hum Mol Genet 18:3026-38. 2009..These in vivo data clearly indicate a role for DNA methylation in mammalian differentiation, and provide the novel insight that critical windows in mammalian developmental epigenetics extend well beyond early embryonic development... - Genome-wide identification of direct targets of the Drosophila retinal determination protein EyelessEdwin J Ostrin
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 16:466-76. 2006..These results suggest that the integrated strategy of computational biology, genomics, and genetics is a powerful approach to identify direct downstream targets for any transcription factor genome-wide... - Differential gene expression profiling of aggressive and nonaggressive follicular carcinomasMichelle D Williams
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 42:1213-20. 2011..Such genes may be used in future prospective validation studies to establish clinically useful and complementary diagnostic markers... - Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancerDavid Luyimbazi
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Mol Cancer Ther 9:2770-84. 2010..Taken together these findings show that rapamycin decreases SCD1 expression, establishing an important link between cell signaling and cancer cell fatty acid synthesis and growth... - Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiationNahyun Choi
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cancer Cell 21:253-65. 2012..Our study suggests that deregulation of epithelial differentiation is a critical step for the initiation of prostate cancers of basal cell origin... - Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cellsLi Zhang
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
Prostate 70:297-304. 2010..miRNAs are a class of naturally occurring small RNAs that generally repress gene expression. They have been shown to actively control diverse biological processes including stem cell differentiation and lineage commitment... - Allelic alterations in pancreatic endocrine tumors identified by genome-wide single nucleotide polymorphism analysisYasuhiko Nagano
Department of Pathology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Box 85, Houston, Texas 77030 4095, USA
Endocr Relat Cancer 14:483-92. 2007..4 +/- 3.1 cm compared with 2.3 +/- 1.3 cm for low AI (P = 0.03). Our study shows that genome-wide allelotyping is a powerful new tool for the analysis of AI in PETs... - B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cellsRita Nahta
Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Mol Cancer Ther 5:1593-601. 2006..These results suggest that BTG1 is a Bcl-2-regulated mediator of apoptosis in breast cancer cells, and that its induction contributes to antisense Bcl-2-mediated cytotoxic effects... - Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3Takao Kanzawa
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 24:980-91. 2005..This study adds a new concept to characterize the pathways by which As(2)O(3) acts to induce autophagic cell death in malignant glioma cells... - In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysisYou Hong Fan
Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Proteome Res 6:1560-7. 2007..Further studies are warranted to investigate the role of interindividual variation in the expression levels of these proteins in cancer susceptibility... - Response to Preprocessing of oligonucleotide array dataLi Zhang
Department of Biostatistics and Applied Mathematics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 447, Houston, Texas 77030, USA
Nat Biotechnol 22:658. 2004 - Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiationRajyalakshmi Luthra
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
J Clin Oncol 24:259-67. 2006..Currently, however, there are no tools to help select optimum therapy. We hypothesized that gene expression profiling could provide clues and biomarkers for selection of therapy... - Semiparametric Bayesian analysis of case-control data under conditional gene-environment independenceBhramar Mukherjee
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Biometrics 63:834-44. 2007..The results reflect that the semiparametric Bayesian model allows incorporation of key scientific evidence in the form of a prior and offers a flexible, robust alternative when standard parametric model assumptions do not hold... - BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cellsWei Cao
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
PLoS Biol 5:e248. 2007..Therefore, by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs... - Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trialRoy S Herbst
Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX 77030 4009, USA
Lancet Oncol 11:619-26. 2010..These results supported investigation of the combination in this larger, definitive phase 3 trial (ZODIAC)... - Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastomaChristopher E Pelloski
Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 12:3935-41. 2006..This study was conducted to determine whether any of these markers are associated with survival time and response to radiation in glioblastoma... - Gene sequence signatures revealed by mining the UniGene affiliation networkJiexin Zhang
Department of Biostatistics and Applied Mathematics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 447, Houston, TX 77030-4009, USA
Bioinformatics 22:385-91. 2006..Such NETs may have fewer quality problems. This work may be helpful in the studies of non-coding RNAs and in the validation of gene sequence databases... - Transmembrane activator and CAML interactor (TACI) haploinsufficiency results in B-cell dysfunction in patients with Smith-Magenis syndromeJavier Chinen
Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
J Allergy Clin Immunol 127:1579-86. 2011..Eighty percent of subjects have a chromosome 17p11.2 microdeletion, which includes TACI. The remaining subjects have mutations sparing this gene... - High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulonsPatrick T McGrath
Department of Physics, Stanford University, Varian Physics, 382 Via Pueblo Mall, Stanford, California 94305, USA
Nat Biotechnol 25:584-92. 2007..Using these motifs, we predict coregulated genes. We verified novel promoter motifs that regulate stress-response genes, including those responding to uranium challenge, a stress-response sigma factor and a stress-response noncoding RNA... - Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populationsEvadnie Rampersaud
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
Diabetes 56:3053-62. 2007..We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish... - HPP1-mediated tumor suppression requires activation of STAT1 pathwaysAbul Elahi
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 122:1567-72. 2008..Moreover, activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties... - Targeting Ku protein for sensitizing of breast cancer cells to DNA-damageLi Zhang
Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University, Medical Center, Washington, DC 20057, USA
Int J Mol Med 14:153-9. 2004..Thus, RNA aptamers against Ku protein show potential to sensitize MCF-7 breast carcinoma cells to DNA-damaging agents... - Learning regulatory programs that accurately predict differential expression with MEDUSAAnshul Kundaje
Department of Computer Science, Center for Computational Learning Systems, Columbia University, New York, NY 10065, USA
Ann N Y Acad Sci 1115:178-202. 2007..With MEDUSA, statistical validation becomes a prerequisite for hypothesis generation and network building rather than a secondary consideration... - CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinomaChangsong Zhang
Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Int J Cancer 123:998-1004. 2008..25% (1/16) cirrhosis patients with CIMP- (p < 0.001). CIMP lead to high levels of expression of telomerase activity through the simultaneous inactivation of multiple genes associated with telomerase activity by concordant methylation... - Short oligonucleotide probes containing G-stacks display abnormal binding affinity on Affymetrix microarraysChunlei Wu
Genomic Institute of Novartis Research Foundation, 10675 John Jay Hopkins Dr, San Diego, CA 92121, USA
Bioinformatics 23:2566-72. 2007..Our findings are expected to be useful in microarray design and data analysis... - Direct electronic detection of prostate-specific antigen in serumMikhail Briman
Department of Physics, University of California Los Angeles, Los Angeles, CA 90095, USA
Small 3:758-62. 2007 - Down-regulation of hepatoma-derived growth factor inhibits anchorage-independent growth and invasion of non-small cell lung cancer cellsJun Zhang
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
Cancer Res 66:18-23. 2006..Our results suggest that HDGF is involved in anchorage-independent growth, cell invasion, and formation of neovasculature of NSCLC. These qualities may contribute to the HDGF-associated aggressive biological behavior of NSCLC... - A new algorithm for analysis of oligonucleotide arrays: application to expression profiling in mouse brain regionsLi Zhang
The Ernest Gallo Clinic and Research Center and Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200 Emeryville, CA 94608, USA
J Mol Biol 317:225-35. 2002..Overall, our findings suggest that this new algorithm may have broad applicability for improving the analysis of oligonucleotide array data... - A microarray-based gastric carcinoma prewarning systemDa Xiang Cui
Bio Nano Engineering Center, Max Planck Institute for Metals Research, D70569 Stuttgart, Germany
World J Gastroenterol 11:1273-82. 2005..To develop a microarray-based prewarning system consisting of gastric cancer chip, prewarning data and analysis software for early detection of gastric cancer and pre-cancerous lesions... - Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastomaJanice M Nigro
Department of Neurological Surgery (Brain Tumor Research Center, University of California, School of Medicine, San Francisco, California, USA
Cancer Res 65:1678-86. 2005.... - [Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus.]Zhong-Jun Xia
Department of Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, P.R. China
Ai Zheng 23:1666-70. 2004..7%), injection site reaction (28.3%),and influenza-like symptoms (9.8%). CONCLUSION: Intratumoral H101 injection showed a distinct efficacy in patients with squamous cell cancer of head and neck or esophagus,and was relatively safe... - Progressive loss of Syk and abnormal proliferation in breast cancer cellsMaria Moroni
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, USA
Cancer Res 64:7346-54. 2004..Because of its progressive and early loss during tumor onset and development, monitoring of Syk loss in breast epithelial cells by noninvasive techniques such as ductal lavage may be a powerful tool for screening purposes... - [Effect of epidermal growth factor receptor-selective tyrosine kinase inhibitor ZD1839 on nasopharyngeal carcinoma cells]Shu-Sen Wang
Department of Internal Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China
Ai Zheng 23:540-4. 2004..CONCLUSION: ZD1839 inhibits the proliferation of nasopharyngeal carcinoma cells and enhances the effect of cytotoxic drugs.ZD1839 induces CNE2 cell cycle arrest in the G1 phase and higher concentration of ZD1839 could induce apoptosis... - VizStruct: exploratory visualization for gene expression profilingLi Zhang
Department of Computer Science and Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA
Bioinformatics 20:85-92. 2004..The purpose of this study is to present an interactive approach for visualizing variations in gene expression profiles and to assess its usefulness for classifying samples... - Fourier harmonic approach for visualizing temporal patterns of gene expression dataLi Zhang
Department of Computer Science and Engineering, State University of New York at Buffalo, 14260, USA
Proc IEEE Comput Soc Bioinform Conf 2:137-47. 2003..The proposed method was tested using two published, array-derived gene expression datasets. Our results demonstrate the effectiveness of the approach... - RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomasDavid Shibata
Division of Gastrointestinal Oncology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL 33612, USA
Int J Cancer 119:801-6. 2006..Given its similar involvement in colon cancer, RAB32 inactivation may represent a component of the oncogenic pathway of microsatellite-unstable gastrointestinal adenocarcinomas... - Antitumor activities of D-glucosamine and its derivativesLi Zhang
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
J Zhejiang Univ Sci B 7:608-14. 2006..GlcNH(2).HCl at dose of 250 mg/kg could enhance significantly the thymus index, and spleen index and could promote T lymphocyte proliferation induced by ConA. The antitumor effect of GlcNH(2).HCl is probably host-mediated and cytocidal... - Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cellsAmitabha Sengupta
Department of Environmental Health Sciences, Columbia University, Mailman School of Public Health, 60 Haven Avenue, New York, NY 10032, USA
Neurotoxicology 28:478-89. 2007..These results provide important insights into the molecular mechanisms underlying Mn neurotoxicity... - Regulation of the HAP1 gene involves positive actions of histone deacetylasesXiantong Xin
Department of Environmental Health Sciences, Columbia University, Mailman School of Public Health, 60 Haven Avenue, B 106, New York, NY 10032, USA
Biochem Biophys Res Commun 362:120-5. 2007..These results reveal a complex mechanism of transcriptional regulation at the HAP1 promoter, involving multiple DNA elements and regulatory proteins... - Phase II clinical study of gemcitabine in the treatment of patients with advanced nasopharyngeal carcinoma after the failure of platinum-based chemotherapyLi Zhang
Department of Medical Oncology, Cancer Center of Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou, 510060, People s Republic of China
Cancer Chemother Pharmacol 61:33-8. 2008..This study was designed to evaluate the anti-tumor activity and toxicity profile of gemcitabine in the treatment of patients with advanced nasopharyngeal carcinoma (NPC) who had been pretreated with platinum-based chemotherapy... - Hidden space support vector machinesLi Zhang
Key Laboratory for Radar Signal Processing, Xidian University, Xi'an 710071, China
IEEE Trans Neural Netw 15:1424-34. 2004..The performance of HSSVMs for pattern recognition and regression estimation is also analyzed. Experiments on artificial and real-world domains confirm the feasibility and the validity of our algorithms... - A model for estimating joint maternal-offspring effects on seed development in autogamous plantsLi Zhang
Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
Physiol Genomics 19:262-9. 2004..This approach will be broadly useful in mapping endosperm traits for many agriculturally important crop plants and also make it possible to study the genetic significance of double fertilization in the evolution of higher plants... - Withaferin A is a potent inhibitor of angiogenesisRoyce Mohan
Discovery Research, EntreMed, Inc, Rockville, Maryland, USA
Angiogenesis 7:115-22. 2004..In conclusion, our findings identify a novel mode of action of withaferin A, which highlights the potential use of this natural product for cancer treatment or prevention... - Analysis of pharmacokinetics, pharmacodynamics, and pharmacogenomics data sets using VizStruct, a novel multidimensional visualization techniqueKavitha Bhasi
Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
Pharm Res 21:777-80. 2004..CONCLUSIONS: The VizStruct approach is a computationally efficient and effective approach for visualizing complex, multidimensional data sets. It could have many useful applications in the pharmaceutical sciences... - Secreted antibody/granzyme B fusion protein stimulates selective killing of HER2-overexpressing tumor cellsJing Zhao
Departments of Biochemistry and Molecular Biology and Immunology, The Fourth Military Medical University, Xi an 710032, China
J Biol Chem 279:21343-8. 2004.... - [Inhibitory effects on hepatocarcinoma and B16 melanoma cells by N-(4-hydrophenyl) retinamide]Li Zhang
Department of Biochemistry, Shanghai Medical Celloge, Fudan University, Shanghai 200032
Shi Yan Sheng Wu Xue Bao 36:421-7. 2003..We believe that 4-HPR has a strong inhibitory effect on melanoma and hepatocarcinoma cells and might become a potent therapeutic agent... - Upregulation of hypoxia inducible factor 1alpha mRNA is associated with elevated vascular endothelial growth factor expression and excessive angiogenesis and predicts a poor prognosis in gastric carcinomaJie Ma
Department of Pathology, Wenzhou Medical College, Wenzhou, Zhejiang Province, China
World J Gastroenterol 13:1680-6. 2007.... - Sequences within domain II of the urokinase receptor critical for differential ligand recognitionYang Li
Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
J Biol Chem 278:29925-32. 2003..Altogether, our data demonstrated that uPAR D2 contains two distinct ligand binding sites for uPA and Vn. Such information will help us better understand the complex roles of uPAR in cell adhesion, migration, and tumor metastasis... - Flavonoids: promising anticancer agentsWenying Ren
Department of Hematology, 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P. R. China
Med Res Rev 23:519-34. 2003..Based on these results, flavonoids may be promising anticancer agents... - [FTIR spectroscopic characterization of freshly removed breast cancer tissues]Su Zhou
Department of General Surgery, Third Hospital of Peking University, Beijing 100083, China
Zhonghua Zhong Liu Za Zhi 28:512-4. 2006..CONCLUSION: FTIR spectroscopy could be a useful tool in clinical diagnosis of breast cancer... - [Palmitic acid induces apoptosis in human hepatoma cell line, HepG2 cells]Li Zhang
Department of Central Laboratory, Dalian Municipal Central Hospital, Dalian University Medical College, Dalian 116033, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:671-6. 2004..To investigate the effects of palmitic acid (PA) on human hepatocytes and its mechanism... - Frondicola australicus gen. nov., sp. nov., isolated from decaying leaf litter from a pine forestLi Zhang
Microbial Gene Research and Resources Facility, School of Biomolecular and Biomedical Sciences, Faculty of Science, Griffith University, Brisbane, QLD 4111, Australia
Int J Syst Evol Microbiol 57:1177-82. 2007..nov., sp. nov. The type strain of the type species is E1HC-02(T) (=JCM 13598(T)=DSM 17894(T))... - Restoring warped document images through 3D shape modelingChew Lim Tan
School of Computing, National University of Singapore 3, Science Drive 2, Singapore
IEEE Trans Pattern Anal Mach Intell 28:195-208. 2006..The results show that the geometric and photometric distortions are mostly removed and the OCR results are improved markedly... - Atlas-driven lung lobe segmentation in volumetric X-ray CT imagesLi Zhang
University of Iowa, Iowa City, IA 52242, USA
IEEE Trans Med Imaging 25:1-16. 2006..96 +/- 0.71 mm and the mean of the similarity indices between the manually defined and computer-defined lobe regions is 0.988. The results indicate a strong agreement between the automatic and manual lobe segmentations... - Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitateYing Sun
Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China
Endocrinology 149:662-71. 2008..Our findings have potential clinical implications for the use of PPARalpha agonists in the treatment of type 2 diabetes... - Phase III study comparing standard radiotherapy with or without weekly oxaliplatin in treatment of locoregionally advanced nasopharyngeal carcinoma: preliminary resultsLi Zhang
Department of Medical Oncology, Cancer Center of Sun Yat Sen University, Guangzhou, People s Republic of China
J Clin Oncol 23:8461-8. 2005..A prospective, randomized, phase III study was performed to evaluate the feasibility and efficacy of concurrent weekly oxaliplatin with radiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma (NPC)... - Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinomaZi Bin Gao
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China
Int J Mol Med 16:599-603. 2005..Therefore, MMP-2 and TIMP-2 may play important roles in the invasion and metastasis of OSCC... - Phase II randomized study comparing the toxicity profile of gemcitabine plus cisplatin with gemcitabine plus oral etoposide in the treatment of advanced non-small cell lung cancerTony S K Mok
Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China
Oncology 68:485-92. 2005..This is a randomized phase II study designed to compare the toxicity profile of a non-platinum-based with a platinum-based regimen in the treatment of advanced non-small cell lung cancer... - Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cellsLi Zhang
Jiangsu Institute of Nuclear Medicine, 20 Qian Rong Road, Wuxi, Jiangsu 214063, China
Eur J Pharmacol 564:18-25. 2007.... - [Effect of expression of coxsackie and adenovirus receptor on antitumor activity of genetically modified adenovirus]Zhong-Yu Yuan
Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China
Ai Zheng 24:502-5. 2005..986). CONCLUSIONS: The expression of CAR closely relates to antitumor activity and efficacy of adenovirus. Also, the efficacy of adenovirus is higher on cancers with increased CAR expression than on those with decreased CAR expression... - T-cell responses to survivin in cancer patients undergoing radiation therapyDorthe Schaue
Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, California 90095 1714, USA
Clin Cancer Res 14:4883-90. 2008..The goal of this study was to determine if radiation therapy (RT) of human cancer enhances or diminishes tumor-specific T-cell reactivity. This is important if immunotherapy is to be harnessed to improve the outcome of cancer radiotherapy... - Methylation-related silencing of p14ARF gene correlates with telomerase activity and mRNA expression of human telomerase reverse transcriptase in hepatocellular carcinomaChangsong Zhang
Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
J Surg Oncol 98:462-8. 2008..And upregulation of telomerase activity has been considered a critical step to tumors. We investigated promoter methylation of p14(ARF) and expression as well as their effect on hTERT expression and telomerase activity in HCC... - A general exact method for synthesizing parallel-beam projections from cone-beam projections via filtered backprojectionLiang Li
Department of Engineering Physics, Tsinghua University, Beijing 100084, People s Republic of China
Phys Med Biol 51:5643-54. 2006..Interestingly, this angular range is larger than that derived in the Feldkamp reconstruction framework. Numerical experiments are performed in the circular scanning case to verify our method... - Sequence verification of oligonucleotides containing multiple arylamine modifications by enzymatic digestion and liquid chromatography mass spectrometry (LC/MS)Lan Gao
Department of Chemistry, Loyola University, 1068 W Sheridan Road, Chicago, IL 60626, USA
J Am Soc Mass Spectrom 19:1147-55. 2008..The results of this study indicate that the LC/MS method described here would be useful in sequencing ODNs modified by multiple arylamines to be used as templates for site-specific mutagenesis studies...