H Wang

Summary

Affiliation: The Picower Institute for Medical Research
Country: USA

Publications

  1. ncbi Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules
    H Wang
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 95:14429-34. 1998
  2. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
  3. ncbi HMG-1 rediscovered as a cytokine
    H Yang
    Laboratory of Biomedical Science, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 15:247-53. 2001
  4. ncbi Spermine inhibition of monocyte activation and inflammation
    M Zhang
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 5:595-605. 1999
  5. ncbi Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan
    M Ombrellino
    Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Shock 15:181-5. 2001
  6. ncbi CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS
    P E Molina
    Department of Surgery, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 10:329-34. 1998
  7. ncbi Extracellular role of HMGB1 in inflammation and sepsis
    H Wang
    Laboratory of Emergency Medicine, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Intern Med 255:320-31. 2004
  8. ncbi Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
  9. ncbi Dual roles for HMGB1: DNA binding and cytokine
    C J Czura
    Laboratory of Biomedical Science, North Shore/Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 7:315-21. 2001
  10. ncbi The increase in levels of interferon-inducible proteins p202a and p202b and RNA-dependent protein kinase (PKR) during myoblast differentiation is due to transactivation by MyoD: their tissue distribution in uninfected mice does not depend on interferons
    H Wang
    Department of Surgery, Northshore University Hospital, Northshore LIJ Research Institute, Manhasset, NY 11030, USA
    J Interferon Cytokine Res 22:729-37. 2002

Detail Information

Publications10

  1. ncbi Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules
    H Wang
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 95:14429-34. 1998
    ..g., spermine) and pharmacologic (e.g., CNI-1493). This role of fetuin as an opsonic participant in macrophage-deactivating mechanisms has implications for understanding and manipulating the innate immune response...
  2. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  3. ncbi HMG-1 rediscovered as a cytokine
    H Yang
    Laboratory of Biomedical Science, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 15:247-53. 2001
    ..When released by activated monocytes, it participates in the development of lethality and it activates downstream cytokine release. This review covers the general features of HMG-1 and its newly appreciated role as a cytokine...
  4. ncbi Spermine inhibition of monocyte activation and inflammation
    M Zhang
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 5:595-605. 1999
    ..Administration of BAP in vivo significantly augmented the development of carrageenan-induced paw edema and nitric oxide release. Thus, endogenous spermine normally inhibits the innate inflammatory response by restraining macrophages...
  5. ncbi Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan
    M Ombrellino
    Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Shock 15:181-5. 2001
    ..These results now reveal a previously unrecognized anti-inflammatory role of fetuin in counter-regulating the innate immune response, and suggest that it may be possible to use fetuin as an experimental anti-inflammatory agent...
  6. ncbi CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS
    P E Molina
    Department of Surgery, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 10:329-34. 1998
    ..These results suggest diverse effects of CNI-1493 that are tissue specific and that confer protection against the hemodynamic and inflammatory responses to LPS...
  7. ncbi Extracellular role of HMGB1 in inflammation and sepsis
    H Wang
    Laboratory of Emergency Medicine, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Intern Med 255:320-31. 2004
    ..Strategies to inhibit HMGB1 activity and release are being investigated in these and other preclinical models of acute and chronic inflammation...
  8. ncbi Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
    ..Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock...
  9. ncbi Dual roles for HMGB1: DNA binding and cytokine
    C J Czura
    Laboratory of Biomedical Science, North Shore/Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 7:315-21. 2001
    ..The delayed kinetics of HMGB1 release indicate that it may be useful to target this toxic cytokine in the development of future therapies...
  10. ncbi The increase in levels of interferon-inducible proteins p202a and p202b and RNA-dependent protein kinase (PKR) during myoblast differentiation is due to transactivation by MyoD: their tissue distribution in uninfected mice does not depend on interferons
    H Wang
    Department of Surgery, Northshore University Hospital, Northshore LIJ Research Institute, Manhasset, NY 11030, USA
    J Interferon Cytokine Res 22:729-37. 2002
    ..This indicates that the synthesis and distribution of these proteins in uninfected adult mice are not affected by endogenous IFNs...