Research Topics
Species | B H RovinSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
The chemokine network in systemic lupus erythematous nephritisBrad H Rovin
The Ohio State University College of Medicine, Department of Internal Medicine, Division of Nephrology, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
Front Biosci 13:904-22. 2008..Anti-chemokine therapies hold the promise of efficacy with fewer adverse side-effects than the non-specific immunosuppression regimens currently in use...- Biomarker discovery in human SLE nephritisBrad H Rovin
Division of Nephrology, Ohio State University College of Medicine, and Columbus Children s Hospital Research Center 43210, USA
Bull NYU Hosp Jt Dis 65:187-93. 2007..The use of urine as a source of SLE nephritis biomarkers is described, and the results of urine biomarker discovery studies using candidate and proteomic approaches are presented... - Biomarkers for lupus nephritis: the quest continuesBrad H Rovin
Division of Nephrology, Ohio State University College of Medicine, 395 W 12th Avenue, Ground Floor, Columbus, OH 43210, USA
Clin J Am Soc Nephrol 4:1858-65. 2009..This article reviews the current status of lupus nephritis biomarker investigation and articulates a perspective of how future efforts should be focused... - Can we personalize treatment for kidney diseases?Brad H Rovin
Division of Nephrology, Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210, OH 43210, USA
Clin J Am Soc Nephrol 4:1670-6. 2009..The goal of this review is to demonstrate that we can personalize therapy for kidney diseases but that considerable investment in new research will be required for personalized medicine to be routinely used in nephrology clinics... - Chemokine induction by the adipocyte-derived cytokine adiponectinBrad H Rovin
The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
Clin Immunol 120:99-105. 2006..We conclude that adiponectin may have pro- and anti-inflammatory effects, and its exact role in specific inflammatory diseases remains to be worked out... - A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritisBrad H Rovin
Nephrology Division, The Ohio State University School of Medicine and Public Health, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
Kidney Int 62:261-5. 2002..This study was undertaken to identify polymorphisms in the 5'-flanking region of the IL-8 gene that correlate with the severity of SLE nephritis... - 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and deathBrad H Rovin
Department of Internal Medicine and Heart Lung Research Institute, Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
Kidney Int 61:1293-302. 2002..To identify endogenous factors that may be responsible for regulating glomerular cell number, the effects of J-series cyclopentenone prostaglandins (PGs) on human glomerular mesangial cell proliferation and death were examined... - Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cellsB H Rovin
Nephrology Division, Department of Internal Medicine, The Ohio State University, 1654 Upham Drive, Columbus, OH 43210 1250, USA
J Am Soc Nephrol 12:1659-67. 2001..These data suggest that certain prostaglandins can limit the extent of renal chemokine expression and thus may have an important role in resolving renal inflammation... - Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc gamma receptor cross-linking: role of IL-1betaB H Rovin
Department of Internal Medicine and the Heart Lung Research Institute, The Ohio State University School of Medicine and Public Health, USA
J Leukoc Biol 69:435-9. 2001..Renal chemokine expression in immune complex disease may thus be triggered as lymphocytes traffic through the kidney and encounter deposited immune complexes... - Chemokine blockade as a therapy for renal diseaseB H Rovin
Department of Medicine, Ohio State University School of Medicine and Public Health, Columbus, USA
Curr Opin Nephrol Hypertens 9:225-32. 2000..Effective use of anti-chemokine therapy for renal disease will require a precise understanding of the unique roles that individual chemokines have in renal pathology, and the genetic factors that regulate chemokine expression... - Chemotactic factors and renal inflammationB H Rovin
Department of Medicine, The Ohio State University College of Medicine and Public Health, Columbus, USA
Am J Kidney Dis 31:1065-84. 1998.... - A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expressionB H Rovin
Department of Medicine, Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
Biochem Biophys Res Commun 259:344-8. 1999..These data identify a polymorphism in the MCP-1 distal regulatory region that affects the level of MCP-1 expression in response to an inflammatory stimulus... - The complex nature of serum C3 and C4 as biomarkers of lupus renal flareD J Birmingham
The Ohio State University, Columbus, OH 43210, USA
Lupus 19:1272-80. 2010.... - Of mice and men: the relevance of the mouse to the study of human SLED J Birmingham
The Department of Internal Medicine, The Heart Lung Research Institute, The Ohio State University, Columbus, USA
Immunol Res 24:211-24. 2001..Thus, generalizing the results of the mouse studies to human SLE and other human IC diseases must be done with caution... - Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking: effects on parenchymal cell IL-8 releaseC B Marsh
Division of Pulmonary and Critical Care Medicine, Ohio State University, Columbus 43210, USA
J Immunol 160:3942-8. 1998..These data suggest that targeted deposits of IgG can stimulate FcgammaRIII-bearing lymphocytes to produce IL-1beta, which induces parenchymal cell IL-8 release... - Oral cyclophosphamide for lupus glomerulonephritis: an underused therapeutic optionAlison McKinley
Department of Internal Medicine, Divisions of Nephrology, Ohio State University, Columbus, Ohio 43210, USA
Clin J Am Soc Nephrol 4:1754-60. 2009..Our experience with POCY suggests that it is well tolerated and consistently associated with good long-term outcomes. Here we report this experience to build a case for maintaining POCY as a therapeutic option in lupus nephritis... - Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European AmericaYan Yang
Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
Am J Hum Genet 80:1037-54. 2007..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease... - Spot urine protein/creatinine ratios are unreliable estimates of 24 h proteinuria in most systemic lupus erythematosus nephritis flaresD J Birmingham
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43220, USA
Kidney Int 72:865-70. 2007..Our work suggests that the use of spot urine P/C ratios will yield more false-positive and -negative diagnoses of glomerulonephritis flares in patients with SLE than the ratio in 24-h urines... - Biomarkers of lupus nephritis determined by serial urine proteomicsXiaolan Zhang
1Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA
Kidney Int 74:799-807. 2008..These studies provide a beginning proteomic analysis aimed at predicting impending renal relapse, relapse severity, and the potential for recovery after SLE nephritis flare... - Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosusY L Wu
Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Research Institute, Columbus, OH, USA
Cytogenet Genome Res 123:131-41. 2008..Therefore, it is concluded that lower copy number of C4 is a risk factor for and higher gene copy number of C4 is a protective factor against SLE disease susceptibility... - Urine chemokines as biomarkers of human systemic lupus erythematosus activityBrad H Rovin
Ohio State University, Nephrology Division, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
J Am Soc Nephrol 16:467-73. 2005..Persistently elevated uMCP-1 after treatment may indicate ongoing kidney injury that may adversely affect renal prognosis... - A mathematical model of venous neointimal hyperplasia formationPaula Budu-Grajdeanu
Mathematical Biosciences Institute, The Ohio State University, Columbus, OH, USA
Theor Biol Med Model 5:2. 2008..The release of growth factors due to surgical injury, oxidative stress and turbulent flow has been suggested as a possible mechanism for neointimal hyperplasia... - Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cellsXiaolan Zhang
Department of Medicine and the Dorothy M. Davis Heart and Lung Institute, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
Kidney Int 65:798-810. 2004..This stress response may be beneficial in preventing renal cell injury or death during kidney inflammation or ischemia... - Management of glomerular proteinuria: a commentaryWilliam A Wilmer
Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210 1250, USA
J Am Soc Nephrol 14:3217-32. 2003..This work is intended primarily for clinical nephrologists; therefore, each antiproteinuria intervention is described in practical detail... - PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cellsWilliam A Wilmer
Division of Nephrology, The Department of Internal Medicine, Dorothy M Davis Heart Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Antioxid Redox Signal 4:877-84. 2002..These studies are the first to identify PPAR-alpha expression by HMC. The results of these studies suggest that TGF-beta1 expression mediated by oxidant stress may be suppressible by PPAR-alpha activation... - The expression of the cytomegalovirus chemokine receptor homolog US28 sequesters biologically active CC chemokines and alters IL-8 productionJulie-Randoph Randolph-Habecker
Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
Cytokine 19:37-46. 2002.... - Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosusBrad H Rovin
Department of Medicine and the Dorothy M Davis Heart and Lung Research Institute, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
Kidney Int 68:1825-33. 2005..A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human SLE... - Cytochrome P450 polymorphisms and the response of lupus nephritis to cyclophosphamide therapyJ Winoto
Department of Internal Medicine, Nephrology Division and 2Department of Statistics, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Clin Nephrol 75:451-7. 2011..This investigation was done to determine the impact of CYP2B6*5 and CYP2C19*2 on the renal response in cyclophosphamide-treated lupus nephritis (LN) patients... - Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flareD J Birmingham
Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
Clin Exp Immunol 143:274-80. 2006..We postulate that E-CR1 consumption reflects E-CR1 function that includes protecting against SLE nephritis... - Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandinXiaolan Zhang
Ohio State University College of Medicine and Public Health, Columbus, OH, USA
Biotechniques 35:1144-6, 1148. 2003 - A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand bindingDaniel J Birmingham
Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
Mol Immunol 44:3510-6. 2007..The physiological role of this polymorphism remains to be determined... - Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G alleleDaniel J Birmingham
Ohio State University, Columbus, OH 43210, USA
Arthritis Rheum 54:3291-9. 2006..The purpose of this study was to assess the relationship between self-perceived stress (SPS), variability in SPS, and the 2 serotonin-related gene polymorphisms as risk factors for SLE flare... - Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cellsWilliam E Ackerman
Department of Obstetrics and Gynecology, Laboratory of Perinatal Research and Division of Maternal Fetal Medicine, The Ohio State University, Columbus, OH 43210, USA
Biol Reprod 73:527-35. 2005..Our data suggest that pharmacological and endogenous PPARG ligands use both receptor-dependent and -independent mechanisms to influence COX2 expression... - Renoprotection: one or many therapies?L A Hebert
Division of Nephrology, The Ohio State University Medical Center, Columbus, Ohio, USA
Kidney Int 59:1211-26. 2001..This work is intended primarily for clinical nephrologists and thus each recommended intervention is described in substantial practical detail... - Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandinsY Xie
Department of Obstetrics and Gynecology, Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, OH 43210, USA
Diabetes Obes Metab 8:83-93. 2006.... - Mycophenolate therapy of SLE membranous nephropathyDan N Spetie
Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
Kidney Int 66:2411-5. 2004..CONCLUSION: These promising results suggest that moderate dose MMF in combination with renoprotective/antiproteinuria therapy warrants further study in the management of SLE MN... - Induction of chemokine expression by adiponectin in vitro is isoform dependentHuijuan Song
Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA
Transl Res 154:18-26. 2009..HMW adiponectin was found in the urine of patients with active lupus nephritis. Therefore, HMW adiponectin may contribute to the renal inflammation of SLE... - Relationship between albuminuria and total proteinuria in systemic lupus erythematosus nephritis: diagnostic and therapeutic implicationsDaniel J Birmingham
Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210 1250, USA
Clin J Am Soc Nephrol 3:1028-33. 2008.... - Thiazide diuretic monotherapy for hypertension: diuretic's dark side just got darkerB H Rovin
Department of Internal Medicine, Ohio State University Medical Center, Columbus, Ohio 43210, USA
Kidney Int 72:1423-6. 2007..Reungjui et al. document a new concern, nephrotoxicity by thiazide monotherapy. This and other recently published evidence of diuretic's 'dark side' is discussed... - Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysisVisith Thongboonkerd
Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, Kentucky, USA
J Am Soc Nephrol 15:650-62. 2004..The identification of these coordinated changes in protein expression in diabetic nephropathy indicates the potential value of proteomic analysis in defining pathophysiology... - A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritisDerek M Fine
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Kidney Int 76:1284-8. 2009..There was little variability between centers, an important feature for clinical trials... - Epidermal growth factor and interleukin-1beta utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cellsWilliam E Ackerman
Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine and Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio 43210, USA
Biol Reprod 71:2079-86. 2004..The synergism observed between IL-1beta and EGF does not rely on augmented NFkappaB function, but rather, occurs through differential use of independent response elements within the COX-2 promoter... - Activation of the Nrf2/antioxidant response pathway increases IL-8 expressionXiaolan Zhang
Department of Internal Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
Eur J Immunol 35:3258-67. 2005.... - The intricate role of complement component C4 in human systemic lupus erythematosusYan Yang
Center for Molecular and Human Genetics, Columbus Children's Research Institute, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA
Curr Dir Autoimmun 7:98-132. 2004..Likewise, elucidation of epistatic genetic factors interacting with C4AQ0 would provide important insights into the intricate roles of C4 in SLE disease susceptibility and pathogenesis... - Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjectsYee Ling Wu
Columbus Children s Research Institute, The Ohio State University, Columbus, Ohio 43205 USA
Adv Exp Med Biol 586:227-47. 2006..The third group had normal serum C4 levels (>15 mg/dL) most of the time and occasionally low C4 and C3 levels that were mostly coincident with disease flares prior to effective medical treatment. Most patients in this group.. - Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short, and RCCX modules: elucidation of C4 CNVs in 50 consanguineous subjects with defined HLYee Ling Wu
Center for Molecular and Human Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
J Immunol 179:3012-25. 2007..These C4 qPCR assays are proven to be robust, sensitive, and reliable, as they have contributed to the elucidation of C4 CNVs in >1000 human samples with autoimmune and neurological diseases... - Proteinuria in a patient receiving anti-VEGF therapy for metastatic renal cell carcinomaDaniel Roncone
Ohio State University Nephrology Division, Columbus, OH 43210, USA
Nat Clin Pract Nephrol 3:287-93. 2007..After 9 months of this therapy, the patient developed proteinuria, which gradually increased to over 6 g/day... - Severe hemorrhagic cystitis associated with prolonged oral cyclophosphamide therapy: case report and literature reviewRuo Qi Hu
Division of Nephrology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
Rheumatol Int 28:1161-4. 2008..This patient is a reminder that severe hemorrhagic cystitis from oral CYP still exists, and that WG can be resistant to even toxic doses of oral CYP. Alternative therapies are discussed... - Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapyBrad H Rovin
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Kidney Int 68:747-59. 2005..When fever does develop, it is usually due to infection. Continuing high steroid dose steroid therapy in those with infection fever may increase the risk of severe sepsis... - The design of ALLHAT may have biased the study's outcome in favor of the diuretic cohortLee A Hebert
Ohio State University Medical Center, 1654 Upham Drive, Columbus, OH 43210, USA
Nat Clin Pract Nephrol 3:60-1. 2007 - The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibilityEnrique Gonzalez
Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
Science 307:1434-40. 2005.... - HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levelsEnrique Gonzalez
Veterans Administration Research Center for AIDS and HIV 1 Infection and University of Texas Health Science Center, San Antonio, TX 78229, USA
Proc Natl Acad Sci U S A 99:13795-800. 2002..In a broader context, the MCP-1 -2578G allele may serve as a genetic determinant of outcome of other disease states in which MP-mediated tissue injury is central to disease pathogenesis... - Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid diseaseHui Wu
David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Arthritis Rheum 52:2396-402. 2005..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members... - Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosusHui Wu
Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:3961-6. 2007..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus... - Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response indexMichelle Petri
Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Arthritis Rheum 58:1784-8. 2008..To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index... - Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal responseMichelle Petri
Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Arthritis Rheum 58:1789-95. 2008..To assess the degree to which physicians agree with each other and with ratings obtained with 3 existing responder indices, in rating the response to treatment of lupus nephritis... - A dinucleotide deletion in CD24 confers protection against autoimmune diseasesLizhong Wang
Division of Immunotherapy, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 3:e49. 2007..The dinucleotide deletion significantly reduced the stability of CD24 mRNA. Our results demonstrate that a destabilizing dinucleotide deletion in the 3' UTR of CD24 mRNA conveys significant protection against both MS and SLE... - APOE Kyoto mutation in European Americans with lipoprotein glomerulopathyBrad H Rovin
N Engl J Med 357:2522-4. 2007 - Diagnostic accuracy study of urine dipstick in relation to 24-hour measurement as a screening tool for proteinuria in lupus nephritisMark J Siedner
Columbia University College of Physicians and Surgeons, New York, NY, USA
J Rheumatol 35:84-90. 2008..We examined the validity of qualitative urine dipstick versus quantitative 24-hour measurement to accurately detect proteinuria, including low-level proteinuria... - Chemokines: therapeutic targets for autoimmune and inflammatory renal diseaseVicki Rubin Kelley
Laboratory of Molecular Autoimmune Disease, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Springer Semin Immunopathol 24:411-21. 2003 - Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progressionLee A Hebert
Am J Kidney Dis 45:788-9; author replyy 789-90. 2005 - Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expressionXi Lin Chen
Discovery Research, AtheroGenics, Incorporated, Alpharetta, GA 30004, USA
Am J Physiol Heart Circ Physiol 290:H1862-70. 2006....