Research Topics
Genomes and Genes | Peter MuscarellaSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4AJunan Li
Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Biochem Biophys Res Commun 304:241-7. 2003..From a biochemical perspective, these data strongly support the study of p16-related pancreatic oncogenesis and cancer therapies in the hamster model...- Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)Junan Li
Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 44:13246-56. 2005..These results provide important information on the molecular mechanism of the functions of SEI-1 and on the comparison between SEI-1 and p16 at both molecular and cellular levels... - Intraoperative assessment of pancreatic neck margin at the time of pancreaticoduodenectomy increases likelihood of margin-negative resection in patients with pancreatic cancerMary Dillhoff
Department of Surgery, Ohio State University, 410 W 10th Ave, N924 Doan Hall, Columbus, OH 43210, USA
J Gastrointest Surg 13:825-30. 2009..We sought to review our experience with pancreaticoduodenectomy (PD) for pancreatic cancer to determine the impact of intraoperative frozen section (FS) analysis on margin-negative resection and long-term outcome... - Failure of normalization of CA19-9 following resection for pancreatic cancer is tantamount to metastatic diseaseSherif R Z Abdel-Misih
Division of Surgical Oncology, The Ohio State University Medical Center James Cancer Hospital, Columbus, OH, USA
Ann Surg Oncol 18:1116-21. 2011..However, little has been reported on outcomes of patients in whom CA19-9 never normalizes. We hypothesize that failure of CA19-9 normalization within 6 months is prognostically equivalent to metastatic disease... - A review of 130 humans enrolled in transgastric NOTES protocols at a single institutionPeter Nau
Division of General Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Columbus, OH 43210 1228, USA
Surg Endosc 25:1004-11. 2011..Herein is a discussion of our experience gained from the initial 130 patients enrolled in transgastric pre-NOTES and NOTES protocols at our institution... - Diagnostic transgastric endoscopic peritoneoscopy: extension of the initial human trial for staging of pancreatic head massesPeter Nau
Division of General Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Columbus, OH 43210 1228, USA
Surg Endosc 24:1440-6. 2010..This report is an update with 10 additional patients in the series and includes bacterial contamination data... - Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimensPeter Muscarella
Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Gene Expr 14:207-16. 2008..7%. Taken together, our results demonstrate that reduced expression of pl6 is a common event in human pheochromocytomas, and the primary cause for such downregulation is inactivating genetic abnormalities in the p16 gene... - Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical featuresMark Bloomston
Department of Surgery, The Ohio State University, Columbus, OH, USA
Ann Surg Oncol 16:2331-8. 2009..We have assessed the status of the Fhit and Wwox proteins encoded by DNA damage susceptible chromosome fragile sites encompassed by FHIT and WWOX tumor suppressor genes... - Pancreatic resection in the octogenarian: a safe option for pancreatic malignancyIoannis Hatzaras
Department of Surgery, The Ohio State University, Columbus, OH, USA
J Am Coll Surg 212:373-7. 2011..We assessed our institution's experience and outcomes with pancreatic resection for malignancy in patients in their ninth decade... - Predictors of survival in periampullary cancers following pancreaticoduodenectomyIoannis Hatzaras
Department of Surgery, The Ohio State University, Columbus, OH, USA
Ann Surg Oncol 17:991-7. 2010..We sought to evaluate predictors of survival for periampullary cancers following pancreaticoduodenectomy to identify biologic behavior... - Cytoreduction results in high perioperative mortality and decreased survival in patients undergoing pancreatectomy for neuroendocrine tumors of the pancreasMark Bloomston
Department of Surgery, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
J Gastrointest Surg 10:1361-70. 2006..However, cytoreduction resulting in incomplete tumor removal carries significant perioperative mortality without long-term survival benefit and should be discouraged... - Pheochromocytoma does not increase risk in laparoscopic adrenalectomyPeter Nau
Center for Minimally Invasive Surgery, Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Columbus, OH 43210 1228, USA
Surg Endosc 24:2760-4. 2010..This study aimed to compare the outcomes of LA for PHE with the results of LA for other adrenal pathologies... - Preoperative carbohydrate antigen 19-9 is most predictive of malignancy in older jaundiced patients undergoing pancreatic resectionMark Bloomston
Department of Surgery, Ohio State University, Columbus, OH 43210, USA
Pancreas 33:246-9. 2006..CONCLUSIONS: Age and preoperative jaundice are more predictive of malignancy than CA19-9 alone unless levels are greater than 150 U/mL. Preoperative CA19-9 levels should be interpreted within the context of these other clinical factors... - Elevated CA 19-9 portends poor prognosis in patients undergoing resection of biliary malignanciesIoannis Hatzaras
Department of Surgery, The Ohio State University Columbus, OH 43210, USA
HPB (Oxford) 12:134-8. 2010..The aim of the present study was to identify predictors of survival after resection... - Novel reconstruction of the extrahepatic biliary tree with a biosynthetic absorbable graftPeter Nau
Department of Surgery Department of Pathology, Ohio State University School of Medicine and Public Health, Columbus, OH, USA
HPB (Oxford) 13:573-8. 2011..This project sought to evaluate a novel approach for repairing common bile duct injuries with a biosynthetic graft. This allows for the reconstruction of the anatomy without necessitating an intestinal bypass... - Radiofrequency energy delivery to the lower esophageal sphincter (Stretta procedure) does not provide long-term symptom controlJohn M Dundon
Center for Minimally Invasive Surgery, Department of Surgery, The Ohio State University, Columbus 43210, USA
Surg Innov 15:297-301. 2008..Responders had less severe preoperative heartburn. Radiofrequency energy delivery to the lower esophageal sphincter may be effective in selected patients for the treatment of gastroesophageal reflux... - The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent mannerJunan Li
Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 43:4394-9. 2004.... - A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growthJunan Li
Departments of Surgery and Internal Medicine, College of Medicine, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA
J Gastrointest Surg 10:207-14. 2006..Further analyses indicate that OSU-03012 induces both proapoptotic and antiproliferative effects in these cells. Taken together, these data suggest that OSU-03012 has potential value as a novel therapy for pancreatic cancer... - Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumorsJunan Li
Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 25:263-8. 2004..These findings indicate that p16 inactivation is a common event in chemically induced hamster tumors, and that this animal model is appropriate for comparative studies evaluating pancreatic cancer therapeutic strategies targeting p16... - Natural-orifice transgastric endoscopic peritoneoscopy in humans: Initial clinical trialJeffrey W Hazey
Division of General Surgery, The Ohio State University Medical Center, Columbus, OH, USA
Surg Endosc 22:16-20. 2008..Reported herein is the first human clinical trial of NOTES, performing transoral transgastric diagnostic peritoneoscopy... - Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancerMark Bloomston
Department of Surgery, Ohio State University, N924 Doan Hall, 410 W 10th Ave, Columbus, OH 43210, USA
Ann Surg Oncol 14:211-7. 2007..Osteonectin has been suggested to be important in the progression of pancreatic cancer but has not been correlated with survival. We determined the osteonectin expression and its influence on survival in patients with ampullary carcinoma... - Clinical factors predictive of malignant and premalignant cystic neoplasms of the pancreas: a single institution experienceNatalie B Jones
Department of Surgery, The Ohio State University Columbus, OH, USA
HPB (Oxford) 11:664-70. 2009..We sought to review our experience with the surgical management of cystic neoplasms of the pancreas to determine pre-operative clinical indicators of malignancy or premalignant (i.e. mucinous) lesions... - Laparoscopic Distal Pancreatectomy with Splenic Conservation: An Operation without Increased MorbidityPeter Nau
Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210 1228, USA
Gastroenterol Res Pract 2009:846340. 2009..4). Conclusions. The laparoscopic distal pancreatectomy is a safe operation with a low morbidity. Splenic conservation does not significantly increase the morbidity of the procedure... - Pancreatectomy for non-pancreatic malignancies results in improved survival after R0 resectionKimberly A Varker
Department of Surgery and Division of Surgical Oncology, The Ohio State University Medical Center, Columbus, OH, USA
World J Surg Oncol 5:145. 2007..Its efficacy for non-pancreatic malignancies is less clear. We reviewed our experience with pancreatectomy for non-pancreatic malignancies to determine outcomes and identify predictors of survival... - Updates and controversies in the treatment of pancreatic cancerKavitha Kosuri
The Ohio State University, USA
Clin Adv Hematol Oncol 4:47-54. 2006..This article summarizes the data from studies that established standards of care and others that created controversy, and reviews novel treatment strategies for this intractable disease... - 50-year appraisal of gastrinoma: recommendations for staging and treatmentE Christopher Ellison
Department of Surgery, The Ohio State University, Columbus, OH, USA
J Am Coll Surg 202:897-905. 2006.... - Delivery of radiofrequency energy to the lower esophageal sphincter improves symptoms of gastroesophageal refluxMichael R Go
Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Surgery 136:786-94. 2004..It may have a role in the treatment of patients with primary reflux and in those who have failed antireflux surgery or who are a high risk for surgery... - Laparoscopic Roux-en-Y gastric bypass in patients with body mass index >70 kg/m2Jason C Roland
Department of Surgery, Division of General and Gastrointestinal Surgery, Center for Minimally Invasive Surgery, Ohio State University Medical Center, Columbus, Ohio 43210, USA
Surg Obes Relat Dis 7:587-91. 2011..The purpose of the present study was to compare laparoscopic Roux-en-Y gastric bypass (LRYGB) and open Roux-en-Y gastric bypass (ORYGB) in megaobese patients...