Research Topics
| W Scott MelvinSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent mannerJunan Li
Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 43:4394-9. 2004....- Roux-en-Y gastric bypass is the operation of choice for bariatric surgeryW Scott Melvin
Division of General Surgery, The Ohio State University, Columbus, Ohio 43210, USA
J Gastrointest Surg 8:398-400; discussion 404-5. 2004 - Gastric bypass surgery is associated with reduced inflammation and less depression: a preliminary investigationCharles F Emery
Department of Psychology, Ohio State University, Columbus, OH 43210, USA
Obes Surg 17:759-63. 2007..This pilot study was designed to examine the relationship of inflammation and depression among gastric bypass patients in a 12-month longitudinal study... - Computer-enhanced robotic telesurgery minimizes esophageal perforation during Heller myotomyW Scott Melvin
Division of General Surgery, Ohio State University, Columbus 43210, USA
Surgery 138:553-8; discussion 558-9. 2005..We hypothesized that computer-enhanced robotic Heller myotomy would reduce intraoperative complications compared with laparoscopic techniques... - Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)Junan Li
Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 44:13246-56. 2005..These results provide important information on the molecular mechanism of the functions of SEI-1 and on the comparison between SEI-1 and p16 at both molecular and cellular levels... - Robot-assisted general surgeryJeffrey W Hazey
Division of General Surgery, The Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
Semin Laparosc Surg 11:107-12. 2004..In this chapter, we review the evolution of robotic technology and its applications in general surgical procedures... - Computer-enhanced vs. standard laparoscopic antireflux surgeryW Scott Melvin
Department of Surgery and the Center for Minimally Invasive Surgery, The Ohio State University School of Medicine and Public Health, Columbus, OH 43210, USA
J Gastrointest Surg 6:11-5; discussion 15-6. 2002..However, operative times are longer, with little difference in outcomes. At the current level of technology and experience, robotic antireflux surgery appears to offer little advantage over standard laparoscopic approaches... - Telerobotic foregut and esophageal surgeryJon C Gould
Department of Surgery and the Center for Minimally Invasive Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Columbus, OH 43210, USA
Surg Clin North Am 83:1421-7. 2003..It is expected that the development and refinement of these technologies will address many of these issues. With continued progress, it is likely that this technology will disseminate widely throughout the surgical community... - Computer-assisted robotic antireflux surgeryJon C Gould
Department of Surgery and the Center for Minimally Invasive Surgery, The Ohio State University School of Medicine and Public Health, Columbus, USA
Surg Laparosc Endosc Percutan Tech 12:26-9. 2002..This review specifically discusses the role of this novel surgical tool in antireflux surgery... - Evolution of the laparoscopic gastric bypassVirginia McGrath
Department of Surgery, Center for Minimally Invasive Surgery, The Ohio State University, Columbus, Ohio 43210, USA
J Laparoendosc Adv Surg Tech A 13:221-7. 2003..Further advances will allow continued improvement in patient outcomes utilizing a variety of minimally invasive surgical approaches to the treatment of this difficult disease... - Minimally invasive pancreatic surgeryW Scott Melvin
Division of General Surgery, Center for Minimally Invasive Surgery, Ohio State University, N 729 Doan Hall, 410 West 10th Ave, Columbus, OH 43210, USA
Am J Surg 186:274-8. 2003..While challenging and controversial, Dr. Zollinger would most likely support the ongoing research in the techniques of pancreatic surgery that can lead only to an improvement in the outcomes of our patients... - Robots in surgery: advanced gastrointestinal applications and credentialingW Scott Melvin
Department of Surgery, The Center for Minimally Invasive Surgery, The Ohio State University, Columbus 43210, USA
J Gastrointest Surg 7:481-3. 2003 - Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4AJunan Li
Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Biochem Biophys Res Commun 304:241-7. 2003..From a biochemical perspective, these data strongly support the study of p16-related pancreatic oncogenesis and cancer therapies in the hamster model... - Natural-orifice transgastric endoscopic peritoneoscopy in humans: Initial clinical trialJeffrey W Hazey
Division of General Surgery, The Ohio State University Medical Center, Columbus, OH, USA
Surg Endosc 22:16-20. 2008..Reported herein is the first human clinical trial of NOTES, performing transoral transgastric diagnostic peritoneoscopy... - Robotic and laparoscopic pancreaticoduodenectomy: a hybrid approachVimal K Narula
Division of General and Gastrointestinal Surgery, Department of Surgery, Center for Minimally Invasive Surgery, The Ohio State University Medical Center, Columbus, OH 43210 1228, USA
Pancreas 39:160-4. 2010..We describe a small series (n = 5) of patients who underwent a hybrid PD for treatment of obstructive jaundice and pancreatic mass... - Evolution of minimally invasive bariatric surgeryJon C Gould
Department of Surgery and the Center for Minimally Invasive Surgery, The Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
Surgery 132:565-71; discussion 571-2. 2002..CONCLUSIONS: HALS may have certain advantages in selected patients and early in a surgeon's experience with minimally invasive gastric bypass. With experience, good results are possible with either approach... - Endoscopic peritoneal access and insufflation: natural orifice transluminal endoscopic surgeryPeter Nau
Division of General Surgery and the Center for Minimally Invasive Surgery, The Ohio State University School of Medicine and Public Health, Columbus, Ohio, USA
Gastrointest Endosc 71:485-9. 2010..Endoscopic insufflation of the peritoneal cavity has not been validated in humans. We report here our experience with pneumoperitoneum established endoscopically with a laparoscopic insufflator... - Reactive oxygen species and EGR-1 gene expression in surgical postoperative peritoneal adhesionsSashwati Roy
Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Avenue, Columbus, OH 73210, USA
World J Surg 28:316-20. 2004..The newly developed rodent model of adhesion may present a useful approach to reproducibly and objectively study molecular mechanisms underlying the dynamic process of de novo adhesion tissue formation... - Delivery of radiofrequency energy to the lower esophageal sphincter improves symptoms of gastroesophageal refluxMichael R Go
Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Surgery 136:786-94. 2004..It may have a role in the treatment of patients with primary reflux and in those who have failed antireflux surgery or who are a high risk for surgery... - Transoral incisionless fundoplication for gastroesophageal reflux disease in an unselected patient populationSebastian V Demyttenaere
Department of Surgery, Center for Minimally Invasive Surgery, The Ohio State University Medical Center, N729 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA
Surg Endosc 24:854-8. 2010..EsophyX is an endolumenal approach to the treatment of gastroesophageal reflux disease (GERD). This report describes one of the earliest and largest North American experiences with this device... - Natural orifice surgery: initial US experience utilizing the StomaphyX device to reduce gastric pouches after Roux-en-Y gastric bypassDean Mikami
The Ohio State University Medical Center for Minimally Invasive Surgery, N717 Doan Hall, Columbus, OH 43210 1228, USA
Surg Endosc 24:223-8. 2010..Revisional gastric bypass surgery is associated with a much higher morbidity and mortality when compared with a primary gastric bypass procedure... - Diagnostic transgastric endoscopic peritoneoscopy: extension of the initial human trial for staging of pancreatic head massesPeter Nau
Division of General Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Columbus, OH 43210 1228, USA
Surg Endosc 24:1440-6. 2010..This report is an update with 10 additional patients in the series and includes bacterial contamination data... - Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humansVimal K Narula
Division of General and Gastrointestinal Surgery, The Ohio State University School of Medicine and Public Health, Columbus, OH, USA
Surg Endosc 23:1331-6. 2009..We report the bacterial load and contamination of the peritoneal cavity in ten patients who underwent diagnostic transgastric endoscopic peritoneoscopy... - Natural orifice translumenal endoscopic surgerySimon Bergman
Department of Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Columbus, OH 43210 1228, USA
Surg Clin North Am 88:1131-48, viii. 2008..Human trials to date are also reviewed and discussed... - Endolumenal fundoplication with EsophyX: the initial North American experienceSimon Bergman
Department of Surgery, Center for Minimally Invasive Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Surg Innov 15:166-70. 2008..Further studies comparing this technique with conventional medical and surgical therapies are necessary... - Operative and nonoperative management of pancreatic pseudocystsSimon Bergman
Department of Surgery, Center for Minimally Invasive Surgery, The Ohio State University, 558 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA
Surg Clin North Am 87:1447-60, ix. 2007..The literature on laparoscopic, endoscopic, and percutaneous management of pancreatic pseudocyst is reviewed here and, based on these data, a treatment algorithm is suggested... - Transgastric instrumentation and bacterial contamination of the peritoneal cavityVimal K Narula
Division of General Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Ohio, Columbus, 43210 1228, USA
Surg Endosc 22:605-11. 2008..We report the bacterial load and contamination of the peritoneal cavity in patients requiring a gastrotomy Roux-en-Y gastric bypass (LSRYGB)... - Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumorsJunan Li
Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 25:263-8. 2004..These findings indicate that p16 inactivation is a common event in chemically induced hamster tumors, and that this animal model is appropriate for comparative studies evaluating pancreatic cancer therapeutic strategies targeting p16... - A computerized analysis of robotic versus laparoscopic task performanceVimal K Narula
Center for Minimally Invasive Surgery, The Ohio State University, Columbus, OH 43210, USA
Surg Endosc 21:2258-61. 2007..We utilized a novel computerized assessment system to objectively describe the technical enhancement in task performance comparing robotic and laparoscopic instrumentation... - Differential gene expression in patients genetically predisposed to pancreatic cancerEmmanuel E Zervos
Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, Ohio, USA
J Surg Res 135:317-22. 2006..The purpose of this study was to identify novel genes expressed in patients with a presumed genetic predisposition or "familial" PCA... - A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growthJunan Li
Departments of Surgery and Internal Medicine, College of Medicine, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA
J Gastrointest Surg 10:207-14. 2006..Further analyses indicate that OSU-03012 induces both proapoptotic and antiproliferative effects in these cells. Taken together, these data suggest that OSU-03012 has potential value as a novel therapy for pancreatic cancer... - 50-year appraisal of gastrinoma: recommendations for staging and treatmentE Christopher Ellison
Department of Surgery, The Ohio State University, Columbus, OH, USA
J Am Coll Surg 202:897-905. 2006.... - Predictors of survival in periampullary cancers following pancreaticoduodenectomyIoannis Hatzaras
Department of Surgery, The Ohio State University, Columbus, OH, USA
Ann Surg Oncol 17:991-7. 2010..We sought to evaluate predictors of survival for periampullary cancers following pancreaticoduodenectomy to identify biologic behavior... - Dermal excisional wound healing in pigs following treatment with topically applied pure oxygenRichard B Fries
Laboratory of Molecular Medicine, Dorothy M. Davis Heart and Lung Research Institute and Comprehensive Wound Center, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
Mutat Res 579:172-81. 2005..Topically applied pure oxygen has the potential of benefiting some wound types. Further studies testing the potential of topical oxygen in pre-clinical and clinical settings are warranted... - Eye motion parameters correlate with level of experience in video-assisted surgery: objective testing of three tasksErgun Kocak
Department of Surgery, The Ohio State University, Columbus, Ohio 43210, USA
J Laparoendosc Adv Surg Tech A 15:575-80. 2005..Our study demonstrates a significant difference in eye motion parameters in surgeons with differing levels of experience. Further testing is needed in actual clinical settings to determine the importance of eye motion during surgery... - Barbed suture for gastrointestinal closure: a randomized control trialSebastian V Demyttenaere
Department of Surgery, Center for Minimally Invasive Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA
Surg Innov 16:237-42. 2009..The V-Loc wound closure device appears to offer comparable gastrointestinal closure to 3-0 Maxon while being significantly faster. Further studies with V-Loc are required to assess its use in laparoscopic surgery... - Do gastrotomies require repair after endoscopic transgastric peritoneoscopy? A controlled studySimon Bergman
Center for Minimally Invasive Surgery, Department of Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Gastrointest Endosc 71:1013-7. 2010..The optimal method for closing gastrotomies after transgastric instrumentation has yet to be determined... - Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical featuresMark Bloomston
Department of Surgery, The Ohio State University, Columbus, OH, USA
Ann Surg Oncol 16:2331-8. 2009..We have assessed the status of the Fhit and Wwox proteins encoded by DNA damage susceptible chromosome fragile sites encompassed by FHIT and WWOX tumor suppressor genes... - Intraoperative assessment of pancreatic neck margin at the time of pancreaticoduodenectomy increases likelihood of margin-negative resection in patients with pancreatic cancerMary Dillhoff
Department of Surgery, Ohio State University, 410 W 10th Ave, N924 Doan Hall, Columbus, OH 43210, USA
J Gastrointest Surg 13:825-30. 2009..We sought to review our experience with pancreaticoduodenectomy (PD) for pancreatic cancer to determine the impact of intraoperative frozen section (FS) analysis on margin-negative resection and long-term outcome... - Preoperative carbohydrate antigen 19-9 is most predictive of malignancy in older jaundiced patients undergoing pancreatic resectionMark Bloomston
Department of Surgery, Ohio State University, Columbus, OH 43210, USA
Pancreas 33:246-9. 2006..CONCLUSIONS: Age and preoperative jaundice are more predictive of malignancy than CA19-9 alone unless levels are greater than 150 U/mL. Preoperative CA19-9 levels should be interpreted within the context of these other clinical factors... - Advanced endoscopic technologiesKevin M Reavis
Division of General Surgery, The Ohio State University, RM N 729 Doan Hall, 410 W Tenth Avenue, Columbus, OH 43210, USA
Surg Endosc 22:1533-46. 2008.... - Pancreatic adenocarcinoma: Clinical Practice Guidelines in OncologyMargaret A Tempero
J Natl Compr Canc Netw 3:598-626. 2005 - Unexpected gastrointestinal tract conditionsS Scott Davis
The Ohio State University Medical Center, The Ohio State University School of Medicine and Public Health, USA
Curr Probl Surg 43:74-118. 2006