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Genomes and Genes | Yunbo LiSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stressYunbo Li
Davis Heart and Lung Research Institute, Department of Internal Medicine and Division of Cardiovascular Medicine, The Ohio State University Medical Center, Columbus, 43210, USA
Pharmacol Res 53:6-15. 2006..The results of this study thus suggested a new mechanism, which might contribute to the cardiovascular protective effects of resveratrol...- Differential roles of 3H-1,2-dithiole-3-thione-induced glutathione, glutathione S-transferase and aldose reductase in protecting against 4-hydroxy-2-nonenal toxicity in cultured cardiomyocytesYunbo Li
Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
Arch Biochem Biophys 439:80-90. 2005..Taken together, this study demonstrates that D3T can induce GSH, GST, and AR in cardiomyocytes, and that the above cellular factors appear to play differential roles in detoxification of HNE in cardiomyocytes... - Upregulation of endogenous glutathione system by 3H-1,2-dithiole-3-thione in pancreatic RINm5F beta-cells as a novel strategy for protecting against oxidative beta-cell injuryHong Zhu
Department of Internal Medicine and Davis Heart and Lung Research Institute, The Ohio State University College of Medicine and Public Health, 473 West 12th Avenue, Columbus, OH 43210, USA
Free Radic Res 41:242-50. 2007..Taken together, this study demonstrates that upregulation of glutathione system by D3T is effective for protecting against oxidative beta-cell injury... - Glutathione and glutathione-linked enzymes in normal human aortic smooth muscle cells: chemical inducibility and protection against reactive oxygen and nitrogen species-induced injuryHong Zhu
Davis Heart and Lung Research Institute, and Department of Internal Medicine and Division of Cardiovascular Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
Mol Cell Biochem 301:47-59. 2007.... - Antioxidants and phase 2 enzymes in cardiomyocytes: Chemical inducibility and chemoprotection against oxidant and simulated ischemia-reperfusion injuryZhuoxiao Cao
Department of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Columbus, OH 43210, USA
Exp Biol Med (Maywood) 231:1353-64. 2006.... - 4-Hydroxy-2-nonenal upregulates endogenous antioxidants and phase 2 enzymes in rat H9c2 myocardiac cells: protection against overt oxidative and electrophilic injuryHong Zhu
Department of Internal Medicine and Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine and Public Health, 473 West 12th Avenue, Columbus, OH 43210, USA
Free Radic Res 40:875-84. 2006..Taken together, this study demonstrates that several antioxidants and phase 2 enzymes in H9c2 cells are upregulated by HNE and that the increased defenses afford protection against overt oxidative and electrophilic cardiac cell injury... - Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stressHong Zhu
Davis Heart and Lung Research Institute and Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Room 012C, 473 West 12th Avenue, Columbus, OH 43210, USA
Free Radic Biol Med 41:132-43. 2006..Taken together, this study demonstrates that Nrf2 is crucial in controlling the expression of bone marrow stromal antioxidants and phase 2 enzymes as well as the susceptibility of these cells to oxidative and electrophilic stress... - Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injuryHong Zhu
Room 012C, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Columbus, OH 43210, United States
FEBS Lett 579:3029-36. 2005.... - Regulation of antioxidants and phase 2 enzymes by shear-induced reactive oxygen species in endothelial cellsCharles I Jones
Department of Internal Medicine, Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
Ann Biomed Eng 35:683-93. 2007.... - Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicalsShijing Xia
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
J Org Chem 71:7268-79. 2006..This study demonstrates how computational chemistry can be used as a tool to rationalize radical stability in the redox environment of biological systems and aid in the future design of more biostable trityl radicals... - Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stressHong Zhu
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA, 24060, USA
Cardiovasc Toxicol 8:71-85. 2008..These findings also implicate Nrf2 as an important signaling molecule for myocardiac cytoprotection... - Coordinated upregulation of a series of endogenous antioxidants and phase 2 enzymes as a novel strategy for protecting renal tubular cells from oxidative and electrophilic stressHong Zhu
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, Virginia 24060, USA
Exp Biol Med (Maywood) 233:753-65. 2008.... - Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: implications for dithiolethione chemoprotectionZhenquan Jia
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA 24060, USA
Mol Cell Biochem 307:185-91. 2008..These findings demonstrate that D3T reacts with thiols, particularly a dithiol, generating superoxide, which may provide a mechanistic explanation for induction of Nrf2-dependent phase 2 enzymes by D3T... - The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavengerHong Zhu
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Research Building II, 1861 Pratt Drive, Blacksburg, VA 24060, USA
Cardiovasc Toxicol 7:202-11. 2007..scavenging ability. Taken together, these results demonstrate that the highly expressed and inducible endogenous NQO1 in cardiovascular cells may act as a potential O2(.-) scavenger... - Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stressHong Zhu
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center Research Building II, 1861 Pratt Drive, Blacksburg, VA 24060, USA
Exp Biol Med (Maywood) 233:463-74. 2008.... - Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-noZhenquan Jia
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, 2265 Kraft Drive, Blacksburg, VA 24060, USA
Brain Res 1197:159-69. 2008.... - Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicityZhenquan Jia
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Research Building II, 1861 Pratt Drive, Blacksburg, VA 24060, USA
Neurochem Res 33:790-800. 2008..The results of this study may have important implications for the neuroprotective effects of LA... - Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stressHong Zhu
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA 24060, USA
Cardiovasc Toxicol 8:115-25. 2008.... - Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cellsZhuoxiao Cao
Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Biochem Biophys Res Commun 292:50-7. 2002.... - Induction of cellular glutathione-linked enzymes and catalase by the unique chemoprotective agent, 3H-1,2-dithiole-3-thione in rat cardiomyocytes affords protection against oxidative cell injuryXingxiang Peng
Department of Pharmaceutical Sciences, St John's University College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Pharmacol Res 45:491-7. 2002.... - Induction of cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicityZhuoxiao Cao
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Atherosclerosis 166:291-301. 2003.... - The role of chemically induced glutathione and glutathione S-transferase in protecting against 4-hydroxy-2-nonenal-mediated cytotoxicity in vascular smooth muscle cellsZhuoxiao Cao
Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Allied Health Professions, Jamaica, NY 11439, USA
Cardiovasc Toxicol 3:165-77. 2003..Taken together, this study demonstrates that D3T can induce both GSH and GST in aortic smooth muscle cells, and that the D3T-augmented cellular defenses afford a marked protection against HNE-induced vascular cell injury... - Induction of endogenous antioxidants and phase 2 enzymes by alpha-lipoic acid in rat cardiac H9C2 cells: protection against oxidative injuryZhuoxiao Cao
Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Allied Health Professions, Jamaica, NY 11439, USA
Biochem Biophys Res Commun 310:979-85. 2003..The results of this study have important implications for the cardioprotective effects of LA... - Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicityZhuoxiao Cao
Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Biochem Biophys Res Commun 316:1043-9. 2004.... - Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injuryZhuoxiao Cao
Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Eur J Pharmacol 489:39-48. 2004..Taken together, this study demonstrates that resveratrol induces antioxidants and phase 2 enzymes in cardiomyocytes, which is accompanied by increased resistance to oxidative and electrophilic cell injury... - The chemical inducibility of mouse cardiac antioxidants and phase 2 enzymes in vivoZhuoxiao Cao
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Biochem Biophys Res Commun 317:1080-8. 2004..This study provides a basis for future investigation of the cardioprotection of chemically induced endogenous antioxidants and phase 2 enzymes in myocardium in animal models of oxidative/electrophilic cardiac disorders... - Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1,2-dithiole-3-thioneZhuoxiao Cao
Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Allied Health Professions, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Cardiovasc Toxicol 4:339-53. 2004..Taken together, our results demonstrate that upregulating GSH biosynthesis by D3T results in a marked protection against ONOO(-)-induced toxicity in vascular cells... - The neuroprotectant ebselen inhibits oxidative DNA damage induced by dopamine in the presence of copper ionsYunbo Li
Department of Pharmaceutical Science, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Neurosci Lett 330:69-73. 2002.... - Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytesYunbo Li
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St Albert Hall, St John s University, Jamaica, NY 11439, USA
Mutat Res 518:123-33. 2002..To our knowledge this study provides the first evidence that endogenous cellular Cu may be capable of bioactivating TBHQ, leading to oxidative DNA damage in cultured cells... - EPR studies on the superoxide-scavenging capacity of the nutraceutical resveratrolZhenquan Jia
Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, 2265 Kraft Drive, Blacksburg, VA 24060, USA
Mol Cell Biochem 313:187-94. 2008.... - Different effects of genistein and resveratrol on oxidative DNA damage in vitroWilliam Win
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. Albert Hall, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Mutat Res 513:113-20. 2002..The above results indicate that despite their similar in vivo anticarcinogenic effects, genistein and resveratrol appear to exert different effects on oxidative DNA damage in vitro...