Research Topics
Genomes and Genes | Junan LiSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Ankyrin repeat: a unique motif mediating protein-protein interactionsJunan Li
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 45:15168-78. 2006....- Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancerJunan Li
Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
Anticancer Res 31:2683-92. 2011..In this study, the levels of gankyrin mRNA and protein expression were assessed in human oral epithelial cell lines, at-risk normal oral tissues, premalignant oral lesions, and primary oral squamous cell carcinomas (OSCCs)... - Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancerJunan Li
Division of Environmental Health Sciences, College of Public Health, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 50:5566-82. 2011..Here, we discuss the regulatory mechanisms of P16 function at the DNA level, the transcription level, and the posttranscriptional level, as well as their implications for the structure-function relationship of P16 and for human cancers... - Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)Junan Li
Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 44:13246-56. 2005..These results provide important information on the molecular mechanism of the functions of SEI-1 and on the comparison between SEI-1 and p16 at both molecular and cellular levels... - The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent mannerJunan Li
Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 43:4394-9. 2004.... - Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteinsYi Guo
Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 48:4050-62. 2009..Overall, our results provide important insights into understanding the biophysical properties of AR proteins... - Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16Anjali Mahajan
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
J Mol Biol 373:990-1005. 2007.... - Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationshipChunhua Yuan
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 43:12152-61. 2004..These results and analyses will shed light on the structural basis of the function of human gankyrin... - An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4Junan Li
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 42:13476-83. 2003.... - Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4AJunan Li
Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Biochem Biophys Res Commun 304:241-7. 2003..From a biochemical perspective, these data strongly support the study of p16-related pancreatic oncogenesis and cancer therapies in the hamster model... - Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumorsJunan Li
Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Mol Carcinog 47:733-8. 2008.... - Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimensPeter Muscarella
Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Gene Expr 14:207-16. 2008..7%. Taken together, our results demonstrate that reduced expression of pl6 is a common event in human pheochromocytomas, and the primary cause for such downregulation is inactivating genetic abnormalities in the p16 gene... - Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteinsYi Guo
Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
J Mol Biol 399:168-81. 2010.... - Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activityJunan Li
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 42:6921-8. 2003..We also report that Tax40N retains the transactivation ability. These results of in vitro studies demonstrate a potentially novel, p16-independent route to regulate CDK4 activity by the Tax oncoprotein in HTLV-1 infected cells... - Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumorsJunan Li
Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 25:263-8. 2004..These findings indicate that p16 inactivation is a common event in chemically induced hamster tumors, and that this animal model is appropriate for comparative studies evaluating pancreatic cancer therapeutic strategies targeting p16... - IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16Yi Guo
Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
Biochem Biophys Res Commun 393:504-8. 2010..Our results reveal the novel role of IKKbeta in P16 phosphorylation and broaden our understanding of the regulation of P16... - A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growthJunan Li
Departments of Surgery and Internal Medicine, College of Medicine, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA
J Gastrointest Surg 10:207-14. 2006..Further analyses indicate that OSU-03012 induces both proapoptotic and antiproliferative effects in these cells. Taken together, these data suggest that OSU-03012 has potential value as a novel therapy for pancreatic cancer... - Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of RbJunan Li
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
Biochemistry 41:3977-83. 2002..These results demonstrate the potential importance of gankyrin in cell cycle control and tumorigenesis and suggest an expanded INK4-CDK4/6-Rb pathway... - Lack of correlation between virus barosensitivity and the presence of a viral envelope during inactivation of human rotavirus, vesicular stomatitis virus, and avian metapneumovirus by high-pressure processingFangfei Lou
Department of Food Science and Technology, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, OH 43210, USA
Appl Environ Microbiol 77:8538-47. 2011..Taken together, our findings suggest that HPP is a promising technology to eliminate viral contaminants in high-risk foods, water, and other fomites...