Research Topics
Species | BRIAN RANDOLPH LAWSONSummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activationYun-Feng Fu
Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China
J Pharmacol Exp Ther 319:799-808. 2006..These findings highlight the fact that DZ2002 likely prevents EAE by suppressing T cell activation and suggest its utility in the treatment of MS and other Th1-mediated inflammatory diseases...- Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculusBrian R Lawson
Department of Biological Sciences, Clemson University, Clemson, SC, USA
BMC Complement Altern Med 7:20. 2007..We and others have previously used N, N-dimethylglycine (DMG) and extracts from the New Zealand green-lipped mussel Perna canaliculus (Perna) as potent immunomodulators to modify ongoing immune and/or inflammatory responses... - Transmethylation in immunity and autoimmunityBrian R Lawson
The Scripps Research Institute, Department of Immunology and Microbial Science, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Clin Immunol 143:8-21. 2012..Further work in defining methylation effects in the immune system is likely to lead to a more detailed understanding of the immune system and may point to the development of novel therapeutic approaches... - Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model systemBrian R Lawson
Diazyme Laboratories Division, General Atomics, San Diego, CA 92186, USA
J Immunol 178:5366-74. 2007..The data suggest that transmethylation is required for CD4 T cell activation, and its inhibition may be a novel approach in the treatment of multiple sclerosis, and other CD4-mediated autoimmune diseases... - Sensors of the innate immune system: their link to rheumatic diseasesArgyrios N Theofilopoulos
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Nat Rev Rheumatol 6:146-56. 2010..These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases... - Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupusDwight H Kono
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:12061-6. 2009..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity... - Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppressionQing-Li Wu
Laboratory of Immunopharmacology and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
J Pharmacol Exp Ther 313:705-11. 2005..These data suggest an important dual role for the S-adenosyl-l-homocysteine hydrolase in both macrophage and T cell function... - S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responsesYun-Feng Fu
Laboratory of Immunopharmacology and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Rd, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China
J Pharmacol Exp Ther 316:1229-37. 2006..These data strongly indicate that DZ2002 suppresses antigen-induced specific immune responses, particularly Th1 responses, through inhibition of AdoHcy hydrolase and elevation of endogenous AdoHcy... - Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial triggerBen A Croker
Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:15028-33. 2008..The SHP1-deficient phenotype is driven by microbes, which activate TLR signaling pathways to elicit IL-1 production. IL-1 signaling via MyD88 elicits inflammatory disease... - The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutationM Katarina Haraldsson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Immunity 28:40-51. 2008..Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases... - T cell homeostatic proliferation elicits effective antitumor autoimmunityWolfgang Dummer
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 110:185-92. 2002..The results indicate that concomitant induction of the physiologic processes of homeostatic T cell proliferation and tumor antigen presentation in lymph nodes triggers a beneficial antitumor autoimmune response... - Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunityBrian R Lawson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 199:547-57. 2004..Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity... - Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB miceBrian R Lawson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 168:5928-32. 2002....
Research Grants
- The Role of Transmethylation Reactions in AutoimmunityBRIAN RANDOLPH LAWSON; Fiscal Year: 2010..This work has the potential of identifying novel therapeutic targets for this and other autoimmune diseases. ..
- The Role of Transmethylation Reactions in AutoimmunityBrian Lawson; Fiscal Year: 2009..This work has the potential of identifying novel therapeutic targets for this and other autoimmune diseases. ..