Research Topics
Species | Michael LairmoreSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytesBindhu Michael
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
Retrovirology 1:39. 2004..Exogenous expression of p30II differentially modulates CREB and Tax-responsive element-mediated transcription through its interaction with CREB-binding protein/p300 and represses tax/rex RNA nuclear export...- Coordinate enhancement of transgene transcription and translation in a lentiviral vectorAlper Yilmaz
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 3:13. 2006.... - Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivoBrenda Yamamoto
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 5:38. 2008.... - International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trialsEdward Murphy
Laboratory Medicine and Epidemiology Biostatistics, University of California at San Francisco and Blood Systems Research Institute, San Francisco, California, USA
Retrovirology 2:22. 2005.... - Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survivalAntara Datta
Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA
Retrovirology 4:49. 2007.... - Molecular determinants of human T-lymphotropic virus type 1 transmission and spreadMichael D Lairmore
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Viruses 3:1131-65. 2011..This review will focus on studies that test HTLV-1 determinants in context to full length infectious clones of the virus providing insights into the mechanisms of transmission and spread of HTLV-1... - Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformationMichael D Lairmore
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 1093, USA
Oncogene 24:6005-15. 2005..Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma... - In vitro and in vivo functional analysis of human T cell lymphotropic virus type 1 pX open reading frames I and IIM D Lairmore
Center for Retrovirus Research, Department of Molecular Virology, Immunology, and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
AIDS Res Hum Retroviruses 16:1757-64. 2000..These systems will be useful to identify molecular mechanisms that explain the functional role of pX ORF I and ORF II-encoded proteins in HTLV-1 replication... - 12th International Conference on Human Retrovirology: HTLV and Related RetrovirusesMichael D Lairmore
Department of Veterinary Biosciences, Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 2:61. 2005..The conference encouraged research in HTLV infections and disease, fostered collaborations, and stimulated new partnerships between clinicians and scientists to encourage clinical trials and novel therapeutic interventions... - Developing and fostering a dynamic program for training in veterinary pathology and clinical pathology: veterinary students to post-graduate educationMichael D Lairmore
Department of Veterinary Bioscience, The Ohio State University, Columbus, OH 43210 1093, USA
J Vet Med Educ 34:464-72. 2007.... - Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13II sensitizes Jurkat T cells to Ras-mediated apoptosisHajime Hiraragi
Center for Retrovirus Research and Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, 43210, USA
J Virol 79:9449-57. 2005..Our data are the first to demonstrate that p13(II) alters Ras-mediated apoptosis in T lymphocytes, and they reveal a potential mechanism by which HTLV-1 alters lymphocyte proliferation... - Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporineB C Gilger
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210 1089, USA
Vet Immunol Immunopathol 49:199-208. 1995..These results suggest that dogs with KCS may not have altered peripheral cellular immunity and that use of topical 2% cyclosporine for treatment of KCS causes a suppression of lymphocyte proliferation after 1 to 3 months of use... - Quantification of human T-cell lymphotropic virus type 1 proviral load by quantitative competitive polymerase chain reactionB Albrecht
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus 43210 1092, USA
J Virol Methods 75:123-40. 1998.... - Human T lymphotropic virus type 1 accessory protein p12I modulates calcium-mediated cellular gene expression and enhances p300 expression in T lymphocytesAmrithraj Nair
Center for Retrovirus Research and Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
AIDS Res Hum Retroviruses 21:273-84. 2005..Collectively, our data strongly indicate that HTLV-1 p12I modulates cellular gene expression patterns to hasten the activation of T lymphocytes and thereby promote efficient viral infection... - Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphomaV Richard
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Leukemia 19:1175-83. 2005..Our data demonstrate that transcriptional regulation of PTHrP in ATLL cells can be controlled by T-cell receptor signaling and the ETS and MAPK ERK pathway in a Tax-independent manner... - Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus type 1 p12(I): association with calreticulin and calnexinW Ding
Department of Veterinary Biosciences, The Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
J Virol 75:7672-82. 2001..Our results indicate that p12(I) directly binds key regulatory proteins involved in calcium-mediated cell signaling and suggest a role of p12(I) in the establishment of HTLV-1 infection by activation of host cells... - Mouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphomaB Zimmerman
The Ohio State University, Department of Veterinary Biosciences, Goss Laboratory, 1925 Coffey Road, Columbus, Ohio 43210 1093, USA
Vet Pathol 47:677-89. 2010.... - Dr. Charles C. Capen--an enduring legacy in veterinary pathologyMichael Lairmore
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
Vet Pathol 45:285-6. 2008 - Lymphangiosarcoma in a young dogJ E Sagartz
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210, USA
Vet Pathol 33:353-6. 1996..The puppy was euthanatized at 8 months of age due to severe septic polyarthritis. Lymphangiosarcoma was documented at the site of the original tumor as well as in the axillary lymph node at necropsy... - Human T-lymphotropic virus type 1 peptides in chimeric and multivalent constructs with promiscuous T-cell epitopes enhance immunogenicity and overcome genetic restrictionM D Lairmore
Center for Retrovirus Research, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA
J Virol 69:6077-89. 1995..In addition, these constructs promote virus-specific helper T-cell responses, thereby overcoming genetically restricted immune responses to the synthetic peptides... - Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300W Zhang
Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
J Virol 75:9885-95. 2001..Collectively, our results demonstrate that CBP/p300 is a cellular protein target for HTLV-1 p30(II) and mediates its transcriptional effects in vivo... - Immunogenicity and conformational properties of an N-linked glycosylated peptide epitope of human T-lymphotropic virus type 1 (HTLV-I)S F Conrad
Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA
Biomed Pept Proteins Nucleic Acids 1:83-92. 1995.... - Enhanced human T-cell lymphotropic virus type I expression following induction of the cellular stress responseJ M Andrews
Department of Veterinary Biosciences, Ohio State University, Columbus 43210
Virology 208:816-20. 1995..These data suggest a relationship between modulation of viral replication and a basic cellular response to stress and have important implications for understanding host cell control mechanisms of HTLV-I expression... - Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolatesA Lazo
Department of Veterinary Anatomy and Cellular Biology, Ohio State University, Columbus, USA
Arch Virol 140:307-23. 1995..These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection... - Transcriptional modulation of viral reporter gene constructs following induction of the cellular stress responseJ M Andrews
Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, OH 43210, USA
Nucleic Acids Res 25:1082-4. 1997..We found the maximal stress-mediated enhancement of transcription with both promoters did not occur until the cells recovered for 24 h following transfection... - The effect of the cellular stress response on human T-lymphotropic virus type I envelope protein expressionJ M Andrews
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus 43210, USA
J Gen Virol 79:2905-8. 1998..However, Env expression in stressed cells treated with a protein synthesis inhibitor (cycloheximide) indicates the effect is mediated through increased translation of viral Env protein... - Humoral hypercalcemia of malignancy: severe combined immunodeficient/beige mouse model of adult T-cell lymphoma independent of human T-cell lymphotropic virus type-1 tax expressionV Richard
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43212, USA
Am J Pathol 158:2219-28. 2001..The SCID/beige mouse model mimics HHM as it occurs in ATL patients, and will be useful to investigate the regulation of PTHrP expression by ATL cells in vivo... - Long-term infection with retroviral structural gene vector provides protection against bovine leukemia virus disease in rabbitsVeronika Altanerova
Cancer Research Institute, Slovak Academy of Sciences, SK-833 91 Bratislava, Slovakia
Virology 329:434-9. 2004..The data indicate that SGV based on HTLV or HIV is a promising approach against lymphotropic disease by human retroviruses... - Calcium-dependent enhancement of transcription of p300 by human T-lymphotropic type 1 p12IAmrithraj M Nair
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Virology 353:247-57. 2006..By targeting a ubiquitous second messenger such as calcium, HTLV-1 p12I may regulate the expression of the cellular transcriptional co-activator p300 to modulate viral gene expression and promote lymphocyte survival... - Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activityBindhu Michael
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Virology 354:225-39. 2006..Collectively, our data indicate that HTLV-1 p30II modulates viral gene expression in a cooperative manner with p300-mediated acetylation... - A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphomaSherry T Shu
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43214, USA
Cancer Res 67:11859-66. 2007..PS-341 reduced PTHrP and MIP-1 alpha expression in tumor cells in vivo. Our results indicate that both PS-341 and Zol are effective treatments for ATLL and HHM, which are refractory to conventional therapy... - Rabbit and nonhuman primate models of toxin-targeting human anthrax vaccinesAndrew J Phipps
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 1093, USA
Microbiol Mol Biol Rev 68:617-29. 2004..The ongoing evaluation of human anthrax vaccines will be dependent on animal efficacy data in the absence of human efficacy data for licensure by the U.S. Food and Drug Administration... - Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformationMurali V P Nadella
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
Retrovirology 5:46. 2008..The expression of PTHrP and the PTH/PTHrP receptor during immortalization or transformation of lymphocytes by HTLV-1 has not been investigated... - Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferationJoshua Arnold
Center for Retrovirus Research, Department of Veterinary Biosciences and Molecular Virology Immunology, The Ohio State University, Columbus, OH 43210, USA
Blood 112:3788-97. 2008..Our data indicate that Hbz expression enhances the proliferative capacity of HTLV-1-infected T cells, playing a critical role in cell survival and ultimately HTLV-1 tumorigenesis in the infected host... - Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13(II) is required for viral infectivity in vivoHajime Hiraragi
Center for Retrovirus Research and Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Virol 80:3469-76. 2006..Our data are the first to indicate that the HTLV-1 mitochondrion-localizing protein p13(II) has an essential biological role during the early phase of virus infection in vivo... - Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulatorIhab Younis
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
J Virol 78:11077-83. 2004..These data are consistent with the critical role of these proteins in viral persistence and pathogenesis in animal models of HTLV-1 and HTLV-2 infection... - Role of accessory proteins of HTLV-1 in viral replication, T cell activation, and cellular gene expressionMichael Bindhu
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210-1093, USA
Front Biosci 9:2556-76. 2004.... - Suppression of tumor growth and cell proliferation by p13II, a mitochondrial protein of human T cell leukemia virus type 1Micol Silic-Benussi
Department of Oncology and Surgical Sciences, University of Padua, Via Gattamelata 64, 35128 Padua, Italy
Proc Natl Acad Sci U S A 101:6629-34. 2004..These findings provide clues into the function of p13(II) as a negative regulator of cell growth and underscore a link between mitochondria, Ca(2+) signaling, and tumorigenicity... - Human T-cell lymphotropic virus type 1 open reading frame II-encoded p30II is required for in vivo replication: evidence of in vivo reversionLee R Silverman
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
J Virol 78:3837-45. 2004..Our data provide evidence that HTLV-1 must maintain its key accessory genes to survive in vivo and that in vivo pressures select for maintenance of wild-type ORF II gene products during the early course of infection... - HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitroJianxin Ye
The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
Blood 102:3963-9. 2003..However, Rex is critical for efficient infection of cells and persistence in vivo... - In vivo analysis of replication and immunogenicity of proviral clones of human T-lymphotropic virus type 1 with selective envelope surface-unit mutationsLee R Silverman
Center for Retrovirus Research and Department of Veterinary Biosciences, the Center for Biostatistics, The Ohio State University, Columbus, 43210, USA
Blood 106:3602-8. 2005..Our data are the first to demonstrate that mutations in critical determinants of HTLV-1 Env SU altered antibody responses and proviral loads, but do not prevent viral replication in vivo... - Isolation and confirmation of human T-cell leukemia virus type 2 from peripheral blood mononuclear cellsMichael D Lairmore
Center for Retrovirus Research, Department of Veterinary Biosciences, Comprehensive Cancer Center, The Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA
Methods Mol Biol 304:113-23. 2005..This chapter briefly summarizes the biology of HTLV-2 infection and disease and details methods to isolate and verify the virus in lymphocyte cultures... - Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cellsWei Ding
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
J Virol 76:10374-82. 2002.... - Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1Joshua Arnold
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Blood 107:3976-82. 2006..This study demonstrates that retroviruses use negative-strand-encoded proteins in the establishment of chronic viral infections... - Human T-cell lymphotropic virus type 1 p12I enhances interleukin-2 production during T-cell activationWei Ding
Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
J Virol 77:11027-39. 2003..These results are the first to indicate that HTLV-1, an etiologic agent associated with lymphoproliferative diseases, uses a conserved accessory protein to induce T-cell activation, an antecedent to efficient viral infection... - Quantitative measurement of anthrax toxin receptor messenger RNA in primary mononuclear phagocytesChristopher Premanandan
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210-1093, USA
Microb Pathog 41:193-8. 2006..Our results indicate that CMG2 transcripts are preferentially expressed over TEM8 transcripts in primary human and mouse macrophages as compared to immortalized cell lines... - Enhancement of LFA-1-mediated T cell adhesion by human T lymphotropic virus type 1 p12I1Seung Jae Kim
Center for Retrovirus Research and Department of Veterinary Biosciences, Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
J Immunol 176:5463-70. 2006..Our data are the first to indicate that HTLV-1 p12(I), in addition to enhancing T cell activation, promotes cell-to-cell spread by inducing LFA-1 clustering on T cells via calcium-dependent signaling...
Research Grants
- MOUSE PATHOBIOLOGY: MODELS OF HUMAN DISEASEMichael Lairmore; Fiscal Year: 2007....
- RESEARCH TRAINING FOR VETERINARY STUDENTSMichael Lairmore; Fiscal Year: 2005....
- ANIMAL MODELS OF MOLECULAR PATHOGENSIS OF HTLV-1Michael Lairmore; Fiscal Year: 2003..Collectively, our research groups provide a coordinated approach to develop state-of-the-art animal models to further knowledge of the events of HTLV-1 pathogenesis. ..
- Mechanism of p12I and p30II in HTLV1 InfectionMichael Lairmore; Fiscal Year: 2003..Our long-term goal is to understand the role of p12-I and p30-II in the establishment of HTLV-1 infection in vivo. ..
- Retrovirus Models of Lymphocyte Transformation/DiseaseMichael Lairmore; Fiscal Year: 2007....