Janice K Kiecolt-Glaser

..Stressors before each of the three conditions provided data on the extent to which yoga speeded an individual's physiological recovery...

..A better understanding of how stressors, negative emotions, and unhealthy meals work together to enhance inflammation will benefit behavioral and nutritional research, as well as the broader biomedical community...

..Previous research on the physical health consequences of childhood abuse and other adversities has been based on data from young or middle-aged adults...

..ClinicalTrials.gov identifier: NCT00519779...

..Dietary intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs also influence inflammation; high n-6:n-3 ratios enhance proinflammatory cytokine production, although n-3 has anti-inflammatory properties...

..Despite some notable methodological challenges, the evidence suggests that learning more about how close relationships influence inflammation will provide important new insights into the ways that relationships impact health...

..This article speculates on future directions for psychoneuroimmunology research, after reviewing the history of the field...

..Resources such as close personal relationships that diminish negative emotions enhance health in part through their positive impact on immune and endocrine regulation...

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..The chronic stress-induced immune dysregulation observed among older caregivers appears to be of sufficient magnitude to impact health. Furthermore, evidence suggests that chronic stress leads to premature aging of the immune system...

..These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response...

..Prior work has suggested that fatigue may be related to inflammation and its associated sickness behaviors; accordingly, our findings may be tapping into this same physiological substrate...

..In this prospective community study, we assessed the relationship between depressive symptoms and changes in inflammatory response after an influenza virus vaccination...

..In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging...

..Our results also shed light on inflammation as a mechanism underlying the effects of hostility on cardiovascular disease morbidity and mortality...

..These data confirm and extend prior evidence implicating oxytocin and vasopressin in couples' positive and negative communication behaviors, and also provide further evidence of their role in an important health outcome, wound healing...

..Odors did not reliably alter IL-6 and IL-10 production, salivary cortisol, heart rate or blood pressure, skin barrier repair following tape stripping, or pain ratings following the cold pressor...

..These relationships provide a window on mechanisms linking marriage and health for men and women across the life span...

..This enhanced cortisol secretion was in turn related to longer time to heal. These findings suggest that the ability to regulate the expression of one's anger has a clinically relevant impact on wound healing...

..Greater anxiety was associated with more IL-6 production by Con A-stimulated leukocytes following the stressor compared to the control visit. The data suggest that stress and anxiety can enhance and prolong AR symptoms...

..The increased morbidity and mortality associated with depression is substantial. In this paper, we review evidence suggesting that depression contributes to disease and death through immune dysregulation...

..PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health...

..This study evaluated the effect of a 3-month exercise program on wound healing, neuroendocrine function, and perceived stress among healthy older adults...

..Translational work is needed to develop innovative treatments able to attenuate stress-induced delays in wound healing...

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..Moreover, specific physiological mechanisms are associated with certain types of interventions. In future research, an increased focus on mechanisms will help to more clearly elucidate pathways linking stress and healing processes...

..Finally, we discuss future implications of current research for understanding the relationships among marital functioning, physiology, and health...

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..Couples whose marriages were troubled at follow-up produced 34% more norepinephrine during conflict, 24% more norepinephrine during the daytime, and 17% more during nighttime hours at Time 1 than the untroubled...

..An understanding of the interactive effects of stress and age is critical to efforts to determine underlying mechanisms, clarify the directionality of effects, and develop effective interventions in early and late life...

..Furthermore, lower HRV and elevated norepinephrine have been associated with a number of adverse health outcomes; accordingly, fatigue may also signal the need for increased vigilance to other health threats...

..This study assessed the joint impact of SES and social support on the expression of a latent herpesvirus, Epstein-Barr virus (EBV), in a group of highly stressed women...

..These findings extend the association between depression and immune function to community-dwelling older adults with chronic, mild depressive symptoms...

..To identify how child maltreatment is associated with quality of life (QOL) among breast cancer survivors...

..Basal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic...

..The data suggest that activation of the HPA and SAM axes, even in individuals within the normal range of depressive symptoms, could mediate MMP levels and wound healing in blister wounds...

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