Research Topics
| Katherine JonesSummaryAffiliation: The Salk Institute Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
A SirT'N repression for NotchKatherine A Jones
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
Mol Cell 42:559-60. 2011....- Outsmarting a mastermindKatherine A Jones
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
Dev Cell 17:750-2. 2009..This new class of inhibitor may find broad utility in blocking protein-protein interactions that underlie many human diseases... - Wnt-induced proteolytic targetingKatherine A Jones
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 22:3077-81. 2008..The discovery of a new Wnt-induced proteolytic targeting system has important implications for the mechanism of Wnt-initiated tumorigenesis... - Transcription strategies in terminally differentiated cells: shaken to the coreKatherine A Jones
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 21:2113-7. 2007 - The multi-tasking P-TEFb complexVanessa Brès
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037 1099, USA
Curr Opin Cell Biol 20:334-40. 2008..Following transcription, P-TEFb accompanies the mature mRNA to the cytoplasm to promote translation elongation... - Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexChristy J Fryer
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 16:1397-411. 2002..Thus MAM may function as a timer to couple transcription activation with disassembly of the Notch enhancer complex on chromatin... - A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 TatVanessa Brès
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 19:1211-26. 2005..These findings suggest that SKIP plays independent roles in transcription elongation and pre-mRNA splicing... - The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genesJose Sierra
Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 20:586-600. 2006..We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells... - Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnoverChristy J Fryer
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Mol Cell 16:509-20. 2004..These findings suggest a role for MAM and CycC:CDK8 in the turnover of the Notch enhancer complex at target genes... - Wild chromatin: regulation of eukaryotic genes in their natural chromatin contextValerio Orlando
Dulbecco Telethon Institute, Institute of Genetics and Biophysics National Research Council, 80131 Naples, Italy
Genes Dev 16:2039-44. 2002 - The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and exportSunnie M Yoh
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 21:160-74. 2007..Thus binding of Spt6 to Ser2-P RNAPII provides a cotranscriptional mechanism to recruit Iws1, REF1/Aly, and associated mRNA processing, surveillance, and export factors to responsive genes...
Research Grants
- Mechanism of beta-catenin and APC-regulated transcription of Wnt target genesKatherine A Jones; Fiscal Year: 2010..The studies outlined here are designed to understand how these events function, and identify important new targets for inhibitors of the Wnt pathway in colon cancer cells. ..
- Mechanism of beta-catenin and APC-regulated transcription of Wnt target genesKatherine Jones; Fiscal Year: 2007..The studies outlined here are designed to understand how these events function, and identify important new targets for inhibitors of the Wnt pathway in colon cancer cells. ..
- CYCLIN T AND HIV1 TAT TRANSACTIVATIONKatherine Jones; Fiscal Year: 2007..5) Analyze the Tat-directed recruitment of cellular elongation factors, RNA processing factors, and chromatin remodeling activities at the integrated HIV- 1 LTR promoter by chromatin immunoprecipitation experiments. ..
- Mechanism of Notch Transcriptional ActivationKatherine Jones; Fiscal Year: 2006..These studies will help elucidate the Notch transactivation mechanism and its role in the modification and destruction of the ICD, and may suggest approaches for blocking Notch signaling in human cancers. ..
- CYCLIN T AND HIV1 TAT TRANSACTIVATIONKatherine Jones; Fiscal Year: 2003..Taken together, these studies will provide important new information on the mechanism of HIV Tat transactivation. ..
- Mechanism of Notch Transcriptional ActivationKatherine Jones; Fiscal Year: 2003..These studies will help elucidate the Notch transactivation mechanism and its role in the modification and destruction of the ICD, and may suggest approaches for blocking Notch signaling in human cancers. ..