Jennifer L Johnson

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum
    Karine G Le Roch
    Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA
    BMC Genomics 9:513. 2008
  2. ncbi Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA
    BMC Immunol 7:28. 2006
  3. ncbi Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 11:533-47. 2010
  4. ncbi Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes
    Daniela B Munafo
    Department of Molecular and Experimental Medicine, Division of Biochemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 402:229-39. 2007
  5. ncbi Cross-talk between IRAK-4 and the NADPH oxidase
    Sandrine Pacquelet
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 403:451-61. 2007
  6. ncbi The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules
    Agnieszka A Brzezinska
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 9:2151-64. 2008
  7. ncbi Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)
    Agnieszka A Brzezinska
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Immunology 127:386-97. 2009
  8. ncbi Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:5647-56. 2011
  9. ncbi Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Infect Immun 79:3607-18. 2011
  10. ncbi The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 391:699-710. 2005

Collaborators

  • Miguel C Seabra
  • BERNARD BABIOR
  • Daniela B Munafo
  • Sergio D Catz
  • Agnieszka A Brzezinska
  • Beverly A Ellis
  • Karine G Le Roch
  • Bruce Beutler
  • Sandrine Pacquelet
  • Malcolm R Wood
  • David Plouffe
  • John R Yates
  • Duk Won D Chung
  • Jacques Prudhomme
  • Henri Vial
  • Kerstin Henson
  • Elizabeth A Winzeler
  • Karine Crozat
  • Hugues Ahiboh
  • William B Kiosses
  • Choukri Ben Mamoun
  • Yingyao Zhou
  • William Witola
  • Sophie Rutschmann
  • William S Lane

Detail Information

Publications13

  1. ncbi A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum
    Karine G Le Roch
    Department of Cell Biology and Neuroscience, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA
    BMC Genomics 9:513. 2008
    ..Here we have employed transcriptome and proteome profiling analyses to characterize the global response of P. falciparum to T4 during the intraerythrocytic cycle of this parasite...
  2. ncbi Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA
    BMC Immunol 7:28. 2006
    ..Consequently, exogenous gene expression in neutrophils is challenging. We report here the transfection of genes and expression of active proteins in human primary peripheral neutrophils using nucleofection...
  3. ncbi Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 11:533-47. 2010
    ..Exocytosis of secretory vesicles in Rab27-deficient neutrophils was functional, suggesting that Rab27 GTPases selectively control the exocytosis of neutrophil granules...
  4. ncbi Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes
    Daniela B Munafo
    Department of Molecular and Experimental Medicine, Division of Biochemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 402:229-39. 2007
    ..Our results suggest that the granules implicated in cargo release towards the surrounding milieu are molecularly and mechanistically different from those involved in their release towards the phagolysosome...
  5. ncbi Cross-talk between IRAK-4 and the NADPH oxidase
    Sandrine Pacquelet
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 403:451-61. 2007
    ..We conclude that IRAK-4 phosphorylates p47phox and regulates NADPH oxidase activation after LPS stimulation...
  6. ncbi The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules
    Agnieszka A Brzezinska
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 9:2151-64. 2008
    ..However, mobilization of CD11b was not affected in Munc13-4-deficient neutrophils, indicating that secretory defects in these cells are limited to a selective group of exocytosable organelles...
  7. ncbi Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)
    Agnieszka A Brzezinska
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Immunology 127:386-97. 2009
    ..Our results identified IRAK-4, p38MAPK and PI3K as important regulatory components with different roles in the signalling pathways that control Toll-like receptor ligand-triggered neutrophil exocytosis...
  8. ncbi Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:5647-56. 2011
    ....
  9. ncbi Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Infect Immun 79:3607-18. 2011
    ....
  10. ncbi The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 391:699-710. 2005
    ..In conclusion, we present evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers...
  11. ncbi DNase I inhibits a late phase of reactive oxygen species production in neutrophils
    Daniela B Munafo
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Innate Immun 1:527-42. 2009
    ..Altogether, our data suggest that inhibition of ROS production by microorganism-derived DNase would contribute to their ability to evade killing...
  12. ncbi Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 6:667-81. 2005
    ..Our results suggest that Akt regulates JFC1/Slp1 function by phosphorylation and may have implications on Rab27a-containing vesicle secretion...
  13. ncbi The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells
    Sergio D Catz
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:11652-7. 2002
    ..We also show that the association of the C2A domain to the membrane is modulated by calcium. From these results we analyze possible mechanisms for the role of JFC1 in cellular trafficking...