Jayaseharan Johnsamuel

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy
    Jayaseharan Johnsamuel
    Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 13:4160-7. 2005
  2. ncbi Synthesis and biological evaluation of neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy
    Youngjoo Byun
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Med Chem 48:1188-98. 2005
  3. ncbi Boronated thymidine analogues for boron neutron capture therapy
    B T S Thirumamagal
    College of Pharmacy, The Ohio State University, Columbus, Ohio 43120, USA
    Nucleosides Nucleotides Nucleic Acids 25:861-6. 2006
  4. ncbi Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer
    Sureshbabu Narayanasamy
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 14:6886-99. 2006
  5. ncbi 3-Carboranyl thymidine analogues (3CTAs) and other boronated nucleosides for boron neutron capture therapy
    Youngjoo Byun
    College of Pharmacy, The Ohio State University, Columbus, OH, USA
    Anticancer Agents Med Chem 6:127-44. 2006
  6. ncbi The synthesis and biochemical evaluation of thymidine analogues substituted with nido carborane at the N-3 position
    Youngjoo Byun
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, 422, Parks Hall, 500, West 12th Avenue, The Ohio State University, Columbus, OH 43210, USA
    Appl Radiat Isot 61:1125-30. 2004
  7. ncbi Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors
    Rolf F Barth
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:6287-95. 2004
  8. ncbi Receptor-targeted liposomal delivery of boron-containing cholesterol mimics for boron neutron capture therapy (BNCT)
    B T S Thirumamagal
    Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, 43210, USA
    Bioconjug Chem 17:1141-50. 2006
  9. ncbi Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties
    Jayaseharan Johnsamuel
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 12:4769-81. 2004
  10. ncbi Comparative molecular field analysis and comparative molecular similarity indices analysis of human thymidine kinase 1 substrates
    Achintya K Bandyopadhyaya
    Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 13:1681-9. 2005

Collaborators

Detail Information

Publications15

  1. ncbi Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy
    Jayaseharan Johnsamuel
    Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 13:4160-7. 2005
    ..While water molecules were essential for docking experiments using dCKc, the absence of water molecules in dCKm did not affect the ability to correctly dock various purine nucleosides...
  2. ncbi Synthesis and biological evaluation of neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy
    Youngjoo Byun
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Med Chem 48:1188-98. 2005
    ..2004, 64, 6280-6286 and 6287-6295). To complete previous structure-activity relationship (SAR) studies, 3-[(closo-o-carboranyl)methyl]thymidine (4) was also synthesized and evaluated...
  3. ncbi Boronated thymidine analogues for boron neutron capture therapy
    B T S Thirumamagal
    College of Pharmacy, The Ohio State University, Columbus, Ohio 43120, USA
    Nucleosides Nucleotides Nucleic Acids 25:861-6. 2006
    ..The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described...
  4. ncbi Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer
    Sureshbabu Narayanasamy
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 14:6886-99. 2006
    ..Therefore, it may have the potential to replace N5-2OH, the current lead 3CTA, in preclinical studies. An in silico model for the binding of this compound to hTK1 was developed...
  5. ncbi 3-Carboranyl thymidine analogues (3CTAs) and other boronated nucleosides for boron neutron capture therapy
    Youngjoo Byun
    College of Pharmacy, The Ohio State University, Columbus, OH, USA
    Anticancer Agents Med Chem 6:127-44. 2006
    ..This review will analyze design strategies applied for the synthesis of boron-containing nucleosides in general and in particular reference to 3CTAs. Results of biological studies with these molecules will be discussed...
  6. ncbi The synthesis and biochemical evaluation of thymidine analogues substituted with nido carborane at the N-3 position
    Youngjoo Byun
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, 422, Parks Hall, 500, West 12th Avenue, The Ohio State University, Columbus, OH 43210, USA
    Appl Radiat Isot 61:1125-30. 2004
    ....
  7. ncbi Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors
    Rolf F Barth
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:6287-95. 2004
    ..Based on these favorable in vitro and in vivo data, neutron capture therapy studies will be initiated using N5-2OH in combination with two non-cell cycle dependent boron delivery agents, boronophenylalanine and sodium borocaptate...
  8. ncbi Receptor-targeted liposomal delivery of boron-containing cholesterol mimics for boron neutron capture therapy (BNCT)
    B T S Thirumamagal
    Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, 43210, USA
    Bioconjug Chem 17:1141-50. 2006
    ....
  9. ncbi Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties
    Jayaseharan Johnsamuel
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 12:4769-81. 2004
    ..In the third group of structural isomers, no significant differences in phosphorylation rates were observed (17-25%). A structure-function hypothesis explaining these results is presented...
  10. ncbi Comparative molecular field analysis and comparative molecular similarity indices analysis of human thymidine kinase 1 substrates
    Achintya K Bandyopadhyaya
    Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 13:1681-9. 2005
    ..Contour maps obtained from CoMFA and CoMSIA models correlated with the experimentally developed SAR...
  11. ncbi A convenient method for the computer-aided molecular design of carborane containing compounds
    Jayaseharan Johnsamuel
    College of Pharmacy, The Ohio State University, 500 W 12th Avenue, Columbus, OH 43210, USA
    Bioorg Med Chem Lett 13:3213-6. 2003
    ..It is intended as a guide for boron chemists interested in using CAMD of carborane containing agents for medical applications such as BNCT...
  12. ncbi Synthesis and biological evaluation of 3'-carboranyl thymidine analogues
    Junhua Yan
    College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem Lett 12:2209-12. 2002
    ..Some of the ether-linked 3'-carboranyl thymidine analogues appeared to be slightly unstable under acidic as well as phosphoryl transfer assay conditions and were, if at all, poor substrates for TK1...
  13. ncbi Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides
    Tesmol G George
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, 43210, USA
    Bioorg Med Chem 14:5699-710. 2006
    ....
  14. ncbi Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy
    Ashraf S Al-Madhoun
    Department of Molecular Biosciences, Division of Veterinary Medical Biochemistry, Swedish University of Agricultural Sciences, Biomedical Center, Uppsala, Sweden
    Cancer Res 64:6280-6. 2004
    ..These findings suggest that compound 10 is a promising candidate for selective delivery of boron-10 to malignant cells, and additional in vivo studies are planned to evaluate it for boron neutron capture therapy of brain tumors...
  15. ncbi Synthesis of a small library of 3-(carboranylalkyl)thymidines and their biological evaluation as substrates for human thymidine kinases 1 and 2
    Ashraf S Al-Madhoun
    Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, The Biomedical Center, SE-75123 Uppsala, Sweden
    J Med Chem 45:4018-28. 2002
    ..Tether lengths of two and five methylene groups in both series gave the highest enzyme activities in the present study. A hypothesis for this result is presented...