Research Topics
| Abraham JacobSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Nerve of origin, tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma resections at a tertiary care academic centerAbraham Jacob
Department of Otolaryngology Head and Neck Surgery, Ohio State University School of Medicine, Columbus, OH 43210, USA
Laryngoscope 117:2087-92. 2007....- Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannomaAbraham Jacob
Department of Otolaryngology, The Ohio State University, Columbus, and Center for Childhood Cancer, Research Institute at Nationwide Children s Hospital, Department of Pediatrics 43210, USA
Otol Neurotol 29:58-68. 2008..Merlin can inhibit phosphatidylinositol 3 kinase (PI3 kinase) by binding to PI3 kinase enhancer long isoform. Therefore, we hypothesized that the PI3 kinase/AKT pathway is activated in VS... - Does packing the eustachian tube impact cerebrospinal fluid rhinorrhea rates in translabyrinthine vestibular schwannoma resections?Abraham Jacob
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Otol Neurotol 28:934-8. 2007.... - Bilateral cerebellopontine angle metastatic melanoma: a case reportAbraham Jacob
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
Ear Nose Throat J 86:388-90. 2007..Metastatic disease to the CPAs must be included in the differential diagnosis for any patient presenting with rapid-onset VIIth or VIIIth cranial nerve symptoms... - Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cellsTina X Lee
Department of Otolaryngology, The Ohio State University College of Medicine, Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
Eur J Cancer 45:1709-20. 2009..Vestibular schwannomas (VS) frequently express high levels of activated AKT. Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas... - Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomasAbraham Jacob
Department of Surgery, Division of Otolaryngology, University of Arizona, Tucson, Arizona 85724, USA
Laryngoscope 122:174-89. 2012.... - Treatment of vestibular schwannoma cells with ErbB inhibitorsMatthew L Bush
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA
Otol Neurotol 33:244-57. 2012..Aberrant phosphorylation of ErbB family receptor tyrosine kinases (RTK) in human vestibular schwannomas (VSs) renders them susceptible to growth suppression by RTK inhibitors... - AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomasMatthew L Bush
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, OH 43212, USA
Neuro Oncol 13:983-99. 2011..The potent growth inhibitory activity of AR42 in schwannoma and meningioma cells suggests that AR42 should be further evaluated as a potential treatment for NF2-associated tumors... - Leaving a lasting impression: ear mold impressions as middle ear foreign bodiesAbraham Jacob
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Ann Otol Rhinol Laryngol 115:912-6. 2006..These patients may benefit from evaluation in conjunction with an otolaryngologist... - Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency miceLong Sheng Chang
Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
Laryngoscope 116:2018-26. 2006..Models for the development of new treatment options in vestibular schwannoma (VS) treatment are lacking. The purpose of this study is to establish a quantifiable human VS xenograft model in mice... - Melatonin: can it stop the ringing?Agnes Hurtuk
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA
Ann Otol Rhinol Laryngol 120:433-40. 2011..We sought to report the efficacy of oral melatonin as treatment for chronic tinnitus and to determine whether particular subsets of tinnitus patients have greater benefit from melatonin therapy than others... - Round window perfusion dynamics: implications for intracochlear therapySarah N Bowe
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Medical Center, Columbus, Ohio 43212, USA
Curr Opin Otolaryngol Head Neck Surg 18:377-85. 2010..The current review explores the background and recent developments in this field... - Fatal case of tumor-associated hemorrhage in a large vestibular schwannomaCharles W Yates
The Ohio State University, Dept of Otolaryngology Head and Neck Surgery, OSU Eye and Ear Institute, 915 Olentangy River Rd, Columbus, OH 43212, USA
Ann Otol Rhinol Laryngol 119:402-5. 2010..During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma. The literature for intratumoral hemorrhage into vestibular schwannoma and the pathologic findings in our case are reviewed... - Spinal myxopapillary ependymoma metastatic to bilateral internal auditory canalsKris R Jatana
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Ann Otol Rhinol Laryngol 117:98-102. 2008..We report a rare case of spinal myxopapillary ependymoma metastatic to both internal auditory canals (IACs) and its implications for diagnosing neurofibromatosis type 2 (NF2)... - Chondromyxoid fibroma of the temporal bone: case report and review of the literatureBradley A Otto
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43210, USA
Ann Otol Rhinol Laryngol 116:922-7. 2007..We describe the clinical presentation, imaging, and pathology results of a patient with chondromyxoid fibroma (CMF) involving the mastoid portion of the temporal bone. The literature covering CMF of the head and neck is reviewed... - Recurrence of isolated multiple myeloma in the skull base: a case report and review of the literatureOmar F Husein
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Medical Center, Columbus 43210, USA
Ear Nose Throat J 86:555-60. 2007..We discuss the patient's presentation, clinical course, and treatment, and we review the relevant scientific literature... - Angiofibrolipoma of the ear canalAbraham Jacob
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, 456 West 10th Avenue, Columbus, OH 43210, U S A
Laryngoscope 115:1461-2. 2005..Described is the first reported case of an angiofibrolipoma of the ear canal in a patient who presented with right-sided conductive hearing loss and a medial canal stenosis... - Use of Mimix hydroxyapatite bone cement for difficult ossicular reconstructionJoel A Goebel
Department of Otolaryngology Head and Neck Surgery, Washington University in St Louis, 660 S Euclid, Campus Box 8115, St Louis, MO 63110, USA
Otolaryngol Head Neck Surg 132:727-34. 2005..To describe the advantages of using Mimix hydroxyapatite (HA) bone cement in reconstructing a variety of ossicular chain abnormalities...