K P Hopfner

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius
    K P Hopfner
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 96:3600-5. 1999
  2. ncbi Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding
    K P Hopfner
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Martinsried, Germany
    Structure 7:989-96. 1999

Detail Information

Publications2

  1. ncbi Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius
    K P Hopfner
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 96:3600-5. 1999
    ..This archaeal B DNA polymerase structure provides a starting point for structure-based design of polymerases or ligands with applications in biotechnology and the development of antiviral or anticancer agents...
  2. ncbi Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding
    K P Hopfner
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Martinsried, Germany
    Structure 7:989-96. 1999
    ..The crystal structure of porcine fIXa in complex with the inhibitor D-Phe-Pro-Arg-chloromethylketone (PPACK) was unable to directly clarify the role of the 99-loop, as the doubly covalent inhibitor induced an active conformation of fIXa...