Vidya Gopalakrishnan

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellum
    Vidya Gopalakrishnan
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Stem Cells 28:1839-47. 2010
  2. ncbi Histone acetylation resulting in resistance to methotrexate in choroid plexus cells
    Preethi Prasad
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Neurooncol 91:279-86. 2009
  3. ncbi Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL
    Dolly G Aguilera
    Department of Pediatrics, University of Texas, M D Anderson Cancer Center, Houston, 77030, USA
    J Neurooncol 93:303-18. 2009
  4. ncbi Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines
    Chandra M Das
    Division of Pediatrics, Children s Cancer Hospital, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Eur J Cancer 46:2771-80. 2010
  5. ncbi Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines
    Chandra M Das
    Department of Pediatrics, Unit 853, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Neurooncol 85:159-70. 2007
  6. ncbi Conversion of myoblasts to physiologically active neuronal phenotype
    Yumi Watanabe
    Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:889-900. 2004
  7. ncbi Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation
    Xiaohua Su
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Mail 1006, Room S13 8136C, Houston, TX 77030, USA
    Mol Cell Biol 26:1666-78. 2006
  8. ncbi Influence of valproic acid on outcome of high-grade gliomas in children
    Amirhadi Masoudi
    Division of Pediatrics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Anticancer Res 28:2437-42. 2008
  9. ncbi Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(?-TRCP) in neuroblastoma cells
    Akanksha Singh
    Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer 117:5189-202. 2011
  10. ncbi Measuring cytotoxicity: a new perspective on LC50
    Ming Zhang
    Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Anticancer Res 27:35-8. 2007

Collaborators

Detail Information

Publications10

  1. ncbi Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellum
    Vidya Gopalakrishnan
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Stem Cells 28:1839-47. 2010
    ..Our findings suggest that although activation of REST-target genes can reprogram myoblasts to assume a general neuronal phenotype, the subtype specificity may then be directed by the brain microenvironment...
  2. ncbi Histone acetylation resulting in resistance to methotrexate in choroid plexus cells
    Preethi Prasad
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Neurooncol 91:279-86. 2009
    ..We also confirmed this finding in human choroid plexus carcinoma cells. Methotrexate should not be combined with HDACI in the treatment of choroid plexus carcinoma...
  3. ncbi Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL
    Dolly G Aguilera
    Department of Pediatrics, University of Texas, M D Anderson Cancer Center, Houston, 77030, USA
    J Neurooncol 93:303-18. 2009
    ....
  4. ncbi Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines
    Chandra M Das
    Division of Pediatrics, Children s Cancer Hospital, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Eur J Cancer 46:2771-80. 2010
    ..These results suggest a potential epigenetic mechanism of regulation of the topoisomerase II-beta gene and a possible role for its increased expression in the sensitivity of SK-N-AS neuroblastoma cells to etoposide...
  5. ncbi Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines
    Chandra M Das
    Department of Pediatrics, Unit 853, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Neurooncol 85:159-70. 2007
    ..In this study, we have examined the ability of the histone deacetylase inhibitor, valproic acid (VPA) to modulate gene expression and sensitize glioblastoma cell lines to the cytotoxic effects of etoposide in vitro...
  6. ncbi Conversion of myoblasts to physiologically active neuronal phenotype
    Yumi Watanabe
    Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:889-900. 2004
    ....
  7. ncbi Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation
    Xiaohua Su
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Mail 1006, Room S13 8136C, Houston, TX 77030, USA
    Mol Cell Biol 26:1666-78. 2006
    ..Furthermore, these results suggest that such a mechanism plays a role in the formation of human medulloblastoma...
  8. ncbi Influence of valproic acid on outcome of high-grade gliomas in children
    Amirhadi Masoudi
    Division of Pediatrics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Anticancer Res 28:2437-42. 2008
    ..As the drug has been given frequently as an antiepileptic drug, a retrospective analysis was conducted to ensure relevant information was not missed before a prospective study was launched...
  9. ncbi Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(?-TRCP) in neuroblastoma cells
    Akanksha Singh
    Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer 117:5189-202. 2011
    ..Because retinoic acid promotes neuronal differentiation, the authors postulated that it involves modulation of REST expression...
  10. ncbi Measuring cytotoxicity: a new perspective on LC50
    Ming Zhang
    Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Anticancer Res 27:35-8. 2007
    ..A dose-response relationship was observed between the parameter k2 in this formula and the concentration of the cytotoxic agent etoposide, in high-grade glioma cells was independent of incubation time...