Research Topics
Genomes and Genes | Jason B FlemingSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Influence of obesity on cancer-related outcomes after pancreatectomy to treat pancreatic adenocarcinomaJason B Fleming
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Unit 444, Houston, TX 77030, USA
Arch Surg 144:216-21. 2009..To examine the influence of obesity, as measured by body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared), on clinicopathologic factors and survival after pancreatectomy to treat adenocarcinoma...- Post-therapy pathologic stage and survival in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant chemoradiationJeannelyn S Estrella
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 118:268-77. 2012..However, analysis of prognostic factors is limited for patients with PDAC treated with neoadjuvant chemoradiation and pancreaticoduodenectomy (PD)... - Long-term survival after multidisciplinary management of resected pancreatic adenocarcinomaMatthew H G Katz
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Ann Surg Oncol 16:836-47. 2009..We evaluated long-term survival and patterns of recurrence in patients treated for PC with contemporary staging and multimodality therapy... - Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinomaXianzhou Song
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 117:734-43. 2011..Although previous studies have identified the role of Axl in the transformation, proliferation, survival, and invasion in cancers, the expression and functions of Axl in pancreatic cancer have not been studied in detail... - TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activationZhongkui Li
Departments of Surgical Oncology and Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 69:7851-9. 2009..Therefore, our results showed that TrkBT1 overexpression induces liver metastasis of pancreatic cancer and uncovered a unique signaling mechanism by which TrkBT1 sequesters GDI and activates RhoA signaling... - Diagnosis and management of cystic neoplasms of the pancreas: an evidence-based approachMatthew H G Katz
Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
J Am Coll Surg 207:106-20. 2008 - Borderline resectable pancreatic cancer: the importance of this emerging stage of diseaseMatthew H G Katz
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
J Am Coll Surg 206:833-46; discussion 846-8. 2008..There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined... - Multidisciplinary management strategy for incidental cystic lesions of the pancreasDebashish Bose
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
J Am Coll Surg 211:205-15. 2010..Management of these patients is unclear because a small but significant number of incidental pancreatic cysts are malignant... - Current status of adjuvant therapy for pancreatic cancerMatthew H G Katz
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncologist 15:1205-13. 2010..Well-designed prospective trials are needed to define the optimal adjuvant or neoadjuvant therapy strategy for these patients... - ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinomaMichael P Kim
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 6:e20636. 2011..Understanding which pancreatic cancer cell populations possess tumor-initiating capabilities is critical to characterizing and understanding the biology of pancreatic CSCs towards therapeutic ends... - Effect of neoadjuvant chemoradiation and surgical technique on recurrence of localized pancreatic cancerMatthew H G Katz
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston, TX 77030, USA
J Gastrointest Surg 16:68-78; discussion 78-9. 2012..To determine the influence of neoadjuvant chemoradiation and standardized dissection of the superior mesenteric artery upon the oncologic outcome of patients with localized pancreatic adenocarcinoma... - Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinomaDeyali Chatterjee
Departments of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 36:409-17. 2012..Our results showed that PNI plays an important role in the progression of PDAC and in predicting prognosis in this group of patients... - High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinomaLan Peng
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 16:3734-42. 2010..However, the expression and significance of nucleolin in pancreatic ductal adenocarcinoma (PDA) have not been studied... - Tumor-node-metastasis staging of pancreatic adenocarcinomaMatthew H G Katz
Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
CA Cancer J Clin 58:111-25. 2008.... - Survival and quality of life of patients with resected pancreatic adenocarcinoma treated with adjuvant interferon-based chemoradiation: a phase II trialMatthew H G Katz
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
Ann Surg Oncol 18:3615-22. 2011..We conducted a phase II trial to assess the survival duration and quality of life of patients who received adjuvant interferon-based chemoradiation for pancreatic adenocarcinoma after pancreaticoduodenectomy... - KrasG12D-induced IKK2/?/NF-?B activation by IL-1? and p62 feedforward loops is required for development of pancreatic ductal adenocarcinomaJianhua Ling
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Centre, Houston, 77030, USA
Cancer Cell 21:105-20. 2012..Therefore, our findings demonstrate the mechanism by which IKK2/?/NF-?B is activated by Kras(G12D) through dual feedforward loops of IL-1?/p62... - Metastatic adult granulosa cell tumor mimicking a benign pancreatic cystRania A Abadeer
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Ann Diagn Pathol 14:457-60. 2010..Immunohistochemical study and clinical history were critical to make the correct diagnosis and to differentiate this tumor from other more commonly encountered cystic neoplasms of the pancreas... - LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasisDavide Melisi
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cancer Ther 7:829-40. 2008..Targeting TbetaRI/II kinase activity on pancreatic cancer cells or the cells of the liver microenvironment represents a novel therapeutic approach to prevent pancreatic cancer metastasis... - Anatomy of the superior mesenteric vein with special reference to the surgical management of first-order branch involvement at pancreaticoduodenectomyMatthew H G Katz
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Ann Surg 248:1098-102. 2008..To describe our approach to resection of pancreatic head cancers, which involve 1 or both of the first-order branches of the superior mesenteric vein (SMV)... - Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient miceMichael P Kim
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Nat Protoc 4:1670-80. 2009..Once established, direct xenograft tumors require 2 and 5 h for heterotopic and orthotopic implantation, respectively, and 5-6 weeks for palpable tumor growth... - Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with a better prognosisQing Zhao
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Ann Diagn Pathol 16:29-37. 2012..Patients with pCR had a better survival than did those who had posttherapy stage I or IIA disease (P < .001). Patients with PDA who received neoadjuvant therapy and had pCR in pancreatectomy are rare but have a better prognosis... - Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experienceSathya Jaganmohan
Department of Gastroenterology, MD Anderson Cancer Center, Houston, TX, USA
Dig Dis Sci 57:732-7. 2012..Duodenal lesions (DLS) are common in patients with familial adenomatosis polyposis (FAP), and screening for duodenal adenocarcinoma (DA) is currently recommended. Endoscopic treatment of DLS is controversial... - Role of EUS-FNA-based cytology in the diagnosis of mucinous pancreatic cystic lesions: a systematic review and meta-analysisNirav Thosani
Department of Internal Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA
Dig Dis Sci 55:2756-66. 2010..Preoperative diagnosis of malignancy in pancreatic cystic lesions (PCLs) remains challenging. Most non-mucinous cystic lesions (NMCLs) are benign, but mucinous cystic lesions (MCLs) are more likely to be premalignant or malignant... - Self-expanding metal stents for biliary drainage in patients with resectable pancreatic cancer: single-center experience with 79 casesAshwani K Singal
Department of Gastroenterology Hepatology and Nutrition, Unit 1466, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Dig Dis Sci 56:3678-84. 2011..To study pre-operative and peri-operative course and outcome on follow up after pancreaticoduodenenctomy (PD) for resectable pancreatic cancer amongst patients receiving self-expanding metal stents (SEMS)... - Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancerRosa F Hwang
Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Ann Surg Oncol 15:1356-66. 2008..We describe the development of an integrated pancreatic tissue bank (PTB) and clinical database for patients with pancreatic cancer and other pancreatic disorders... - Current diagnosis and management of unusual pancreatic tumorsMelinda M Mortenson
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg 196:100-13. 2008.... - K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathwaysYoichi Matsuo
Department of Gastroenterology, The University of Texas M D Anderson Cancer Center, Houston, USA
Mol Cancer Res 7:799-808. 2009.... - The recognition and surgical management of heritable lesions of the pancreasMichael P Kim
Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Surg Oncol Clin N Am 18:99-119, ix. 2009.... - The fallen one: the inferior parathyroid gland that descends into the mediastinumGlenda G Callender
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Am Coll Surg 208:887-93; discussion 893-5. 2009..Our nomenclature system designates these glands as "fallen" (type F) glands. This study reviews our experience with type F parathyroid glands to determine which can be retrieved successfully through a cervical incision... - Identification of cancer stem cells in human gastrointestinal carcinoid and neuroendocrine tumorsPuja Gaur
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1402, USA
Gastroenterology 141:1728-37. 2011..We sought to identify gastrointestinal neuroendocrine CSCs (N-CSCs) in surgical specimens and a NET cell line and to characterize novel N-CSC therapeutic targets... - Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreasDan G Blazer
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
JOP 9:56-60. 2008..Herein, we report what to our knowledge is the first description of pancreatic resection of metastatic endometrial carcinoma... - Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoterBailu Peng
Departments of Surgical Oncology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:15193-8. 2010.... - Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cellsBailu Peng
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 8:3628-38. 2002..We seek to determine the role of Smad4/DPC4 in the suppression of tumor cell growth and in the regulation of TGF-beta-mediated expression of cell-cycle regulatory genes p15(ink4b) and p21(waf1)... - Combined esophagectomy and pancreaticoduodenectomy: expanded indication for supercharged jejunal interpositionJae Yul Kim
Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Gastrointest Surg 15:1893-5. 2011..Combined pancreaticoduodenectomy and esophagectomy poses a challenge for reconstruction... - One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United StatesJames C Yao
Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 26:3063-72. 2008..Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristic of these tumors... - Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapyJason B Fleming
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-8593, USA
Mol Cancer Res 3:413-23. 2005..We have found that silencing mutant K-ras through RNAi results in alteration of tumor cell behavior in vitro and suggests that targeting mutant K-ras specifically might be effective against pancreatic cancer in vivo... - Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in miceSean P Dineen
Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
Cancer Res 68:4340-6. 2008..Our results show an underappreciated mechanism of action that may directly contribute to the antitumor activity of angiogenesis inhibitors that block the VEGFR2 pathway... - Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in miceAdam W Beck
Simmons Comprehensive Cancer Center and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA
Int J Cancer 118:2639-43. 2006..In conclusion, 3G4 enhanced the anti-tumor and anti-metastatic activity of gemcitabine without contributing to toxicity... - Superficial femoral vein as a conduit for portal vein reconstruction during pancreaticoduodenectomyJason B Fleming
Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Arch Surg 140:698-701. 2005 - Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancerShane E Holloway
Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA
J Am Coll Surg 200:371-7. 2005..Protein analysis confirms the microarray results and collocalization of Cyr61, and alpha(v) suggests that interaction between Cyr61 and alpha(v)beta(3) promotes formation of peritoneal metastases... - Functional imaging of angiogenesis in an orthotopic model of pancreatic cancerJason B Fleming
The Hamon Center for Therapeutic Oncology Research and the Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8593, USA
J Cell Biochem 90:492-501. 2003..In this review, we will use the example of orthotopic mouse models of pancreatic cancer as a tool to survey the challenges and possibilities of functional imaging of angiogenesis, a critical determinant of metastasis... - Inactivation of tumor suppressor genes by promoter methylation is important in the pathogenesis of pancreatic cancerJason B Fleming
Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-8593, USA
Cancer Biol Ther 1:297-9. 2002 - Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenograftsShane E Holloway
Department of Surgery, Division of Surgical Oncology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-8593, USA
Ann Surg Oncol 13:1145-55. 2006..CONCLUSIONS: Blockade of VEGF receptor 2 activation by tumor-derived VEGF decreases tumor vessel function and growth of some human pancreatic adenocarcinoma cell lines in mice...
Research Grants
- VEGF Promotes Pancreatic Tumor Cell Arrest in the LiverJason Fleming; Fiscal Year: 2005..abstract_text> ..