THOMAS THOMAS EDGINGTON EDGINGTON

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Surfing tissue factor. From the predicted to the discovery and elucidation of unanticipated functions and biology of potential significance
    Thomas S Edgington
    The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Thromb Haemost 98:36-7. 2007
  2. ncbi In vivo interrogation of the molecular display of atherosclerotic lesion surfaces
    Cheng Liu
    Department of Immunology and Vascular Biology, Mail Code 204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 1092, USA
    Am J Pathol 163:1859-71. 2003
  3. ncbi The structural basis of function of the TF. VIIa complex in the cellular initiation of coagulation
    T S Edgington
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 78:401-5. 1997
  4. ncbi A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas
    R Lin
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oncogene 26:851-8. 2007
  5. ncbi The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex
    M Huang
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92027, USA
    J Mol Biol 275:873-94. 1998
  6. ncbi Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response
    S T Fan
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Clin Invest 87:50-7. 1991
  7. ncbi Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade
    N Mackman
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Biochemistry 28:1755-62. 1989
  8. ncbi Functional analysis of the human tissue factor promoter and induction by serum
    N Mackman
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 87:2254-8. 1990
  9. ncbi Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18
    D C Altieri
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    J Immunol 145:662-70. 1990
  10. ncbi Conservation of tissue factor primary sequence among three mammalian species
    B S Andrews
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Gene 98:265-9. 1991

Research Grants

  1. VASCULAR BIOLOGY IN CANCER
    Thomas Edgington; Fiscal Year: 2006
  2. Core--Biotechnology
    Thomas Edgington; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Surfing tissue factor. From the predicted to the discovery and elucidation of unanticipated functions and biology of potential significance
    Thomas S Edgington
    The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Thromb Haemost 98:36-7. 2007
  2. ncbi In vivo interrogation of the molecular display of atherosclerotic lesion surfaces
    Cheng Liu
    Department of Immunology and Vascular Biology, Mail Code 204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 1092, USA
    Am J Pathol 163:1859-71. 2003
    ..These peptides provide a set of probes to interrogate the cell surface repertoire associated with atherogenesis and thrombotic complications...
  3. ncbi The structural basis of function of the TF. VIIa complex in the cellular initiation of coagulation
    T S Edgington
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 78:401-5. 1997
    ..Docking of the VIIa Gla-domain to the latter region of TF appears to contribute to substrate assembly. The current data suggest an extended embrace between TF and VIIa to form the bimolecular enzyme TF.VIIa...
  4. ncbi A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas
    R Lin
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oncogene 26:851-8. 2007
    ..This ncRNA was overexpressed in all five non-hepatic human carcinomas analysed, consistent with a potential marker for neoplastic cells and potential participant in the molecular cell biology of neoplasia...
  5. ncbi The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex
    M Huang
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92027, USA
    J Mol Biol 275:873-94. 1998
    ..The TF. 5G9 structure provides insights into the mechanism by which the antibody 5G9 inhibits formation of the TF.VIIa.X ternary complex...
  6. ncbi Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response
    S T Fan
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Clin Invest 87:50-7. 1991
    ....
  7. ncbi Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade
    N Mackman
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Biochemistry 28:1755-62. 1989
    ..These factors included AP-1 and AP-2 which can mediate the effects of phorbol esters, agonists known to induce TF expression in monocytes and vascular endothelial cells...
  8. ncbi Functional analysis of the human tissue factor promoter and induction by serum
    N Mackman
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 87:2254-8. 1990
    ..Based on this functional map, we propose that the elaborate pattern of TF expression by cells results from a relatively complex promoter...
  9. ncbi Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18
    D C Altieri
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    J Immunol 145:662-70. 1990
    ....
  10. ncbi Conservation of tissue factor primary sequence among three mammalian species
    B S Andrews
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Gene 98:265-9. 1991
    ....
  11. ncbi The serine protease cofactor factor V is synthesized by lymphocytes
    N L Shen
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    J Immunol 150:2992-3001. 1993
    ....

Research Grants3

  1. VASCULAR BIOLOGY IN CANCER
    Thomas Edgington; Fiscal Year: 2006
    ..Weekly seminars and review of data are conducted by each of the faculty members with their group. M.D., Ph.D. and M.D./Ph.D. candidates are recruited and prepared for an independent investigative career. ..
  2. Core--Biotechnology
    Thomas Edgington; Fiscal Year: 2007
    ..The core personnel assist the various investigators in conduct of more sophisticated electrophoretic techniques and processing for mass spectroscopy. They supervise the proper use of common shared equipment. ..