Research Topics
| Linda CurtissSummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Participation of innate and acquired immunity in atherosclerosisL K Curtiss
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Immunol Res 21:167-76. 2000..By using mouse models of hyperlipidemia, our laboratory is addressing in vivo the participation of both innate inflammatory responses and acquired immune responses in atherosclerosis...- Apolipoprotein E and atherosclerosisL K Curtiss
The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
Curr Opin Lipidol 11:243-51. 2000..Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease... - Emerging role of Toll-like receptors in atherosclerosisLinda K Curtiss
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Lipid Res 50:S340-5. 2009..TLR2- and 4-expression exert an overall proatherogenic effect in hyperlipidemic mice. TLR activation of the endothelium promotes lipid accumulation and leukocyte accumulation within lesions... - The toll of Toll-like receptors, especially toll-like receptor 2, on murine atherosclerosisL K Curtiss
The Scripps Research Institute, Department of Immunology, IMM 17, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Drug Targets 8:1230-8. 2007..Thus, TLR2-mediated cell activation in response to endogenous and exogenous agents is proatherogenic in hyperlipidemic mice... - What is so special about apolipoprotein AI in reverse cholesterol transport?Linda K Curtiss
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Arterioscler Thromb Vasc Biol 26:12-9. 2006.... - Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic eventsAdam E Mullick
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 205:373-83. 2008..This is the first report of in vivo site-specific expression of endothelial cell TLR2. Expression of this receptor on endothelial cells contributed to early atherosclerotic processes in lesion-prone areas of the mouse aorta... - Atherosclerosis in mice is not affected by a reduction in tissue factor expressionRachel E Tilley
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Arterioscler Thromb Vasc Biol 26:555-62. 2006..To determine whether tissue factor (TF) contributes to the progression of atherosclerotic lesions in mice... - Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutationsNatalie K Schiller
Scripps Research Institute, Department of Immunology, La Jolla, Calif, USA
Arterioscler Thromb Vasc Biol 22:1341-6. 2002.... - Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein AI overexpressionDavid T Valenta
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Arterioscler Thromb Vasc Biol 26:1572-8. 2006..The atheroprotective properties of macrophage-derived PLTP were not observable in the presence of elevated plasma concentrations of apoAI... - Transcriptional repression of atherogenic inflammation: modulation by PPARdeltaChih Hao Lee
Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 302:453-7. 2003..PPARdelta and its ligands may thus serve as therapeutic targets to attenuate inflammation and slow the progression of atherosclerosis... - Leukocyte-derived hepatic lipase increases HDL and decreases en face aortic atherosclerosis in LDLr-/- mice expressing CETPNeil J Hime
Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
J Lipid Res 49:2113-23. 2008..Thus, leukocyte-derived HL in CETPtgLDLr(-/-) mice has an atheroprotective role that may involve increased HDL levels... - DNA vaccination against VEGF receptor 2 reduces atherosclerosis in LDL receptor-deficient miceRamona J Petrovan
The Scripps Research Institute, Department of Immunology, IMM 17, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
Arterioscler Thromb Vasc Biol 27:1095-100. 2007.... - Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiencyDavid T Valenta
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
J Lipid Res 49:24-32. 2008..Thus, unlike total systemic PLTP, locally produced macrophage-derived PLTP beneficially alters lipoprotein metabolism and reduces lesion progression in hyperlipidemic mice... - Expression of the Lyst(beige) mutation is atheroprotective in chow-fed apolipoprotein E-deficient miceRamona J Petrovan
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
J Lipid Res 49:429-37. 2008..Thus, expression of the beige mutation in all cell types involved in lesion development contributed to atheroprotection in chow-fed ApoE(-/-) mice... - Modulation of atherosclerosis in mice by Toll-like receptor 2Adam E Mullick
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 115:3149-56. 2005..These studies support the concept that chronic or recurrent microbial infections may contribute to atherosclerotic disease. Additionally, these data suggest the presence of host-derived endogenous TLR2 agonists... - TLR2 in murine atherosclerosisPeter S Tobias
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Semin Immunopathol 30:23-7. 2008..It does involve lipid accumulation, but inflammation appears to be an important driving factor. Consequently, our laboratory undertook to examine the role(s) of TLRs, and especially TLR2, in murine models of atherosclerosis... - Toll-like receptors and atherosclerosis: key contributors in disease and health?Adam E Mullick
Department of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA
Immunol Res 34:193-209. 2006..Finally, an appreciation of the pro- and anti-atherosclerotic mechanisms of TLR activation over the entire lifetime of an organism will provide clues to the role of TLRs in both health and disease... - Overexpression of human ApoAI transgene provides long-term atheroprotection in LDL receptor-deficient miceDavid T Valenta
Department of Immunology, The Scripps Research Institute, 10550 North Torrey, Pines Road, La Jolla, CA 92037, USA
Atherosclerosis 189:255-63. 2006..This was observed without a change in total HDL cholesterol levels. Thus, elevated levels of human apoAI in LDL receptor-deficient mice lacking mouse apoAI conferred profound protection against diet-induced over extended periods of time... - Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- miceNatalie K Schiller
The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
J Lipid Res 45:1398-409. 2004..These results suggested that impaired macrophage function by itself did not account for the stable lesion morphology of beige,LDLr-/- double-mutant mice... - Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progressionWilliam A Boisvert
Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
Am J Pathol 168:1385-95. 2006.... - PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosisGrant D Barish
Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:4271-6. 2008..These results reveal that PPARdelta antagonizes multiple proinflammatory pathways and suggest PPARdelta-selective drugs as candidate therapeutics for atherosclerosis... - Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cellsCatherine M Desrumaux
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Lipid Res 44:1453-61. 2003..7 cells as well. Thus, this study demonstrates that PLTP is expressed by macrophages, is regulated by cholesterol loading, and is present in atherosclerotic lesions... - Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in miceJonathan M Gitlin
Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
Am J Pathol 174:343-50. 2009..These studies indicate that selectin ligands, particularly those for E- and P-selectins, play an important role in the pathogenesis of atherosclerosis by regulating macrophage accumulation in atherosclerotic lesions... - Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)Therese Wiedmer
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:13296-301. 2004.... - IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosisChristoph J Binder
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
J Clin Invest 114:427-37. 2004..Thus, IL-5 links adaptive and natural immunity specific to epitopes of OxLDL and protects from atherosclerosis, in part by stimulating the expansion of atheroprotective natural IgM specific for OxLDL... - Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypesLaura J Pinderski
Department of Medicine, University of California Los Angeles, USA
Circ Res 90:1064-71. 2002..These studies demonstrate that T lymphocyte IL-10 can influence the function of other immune cells to reduce the development of advanced atherosclerotic lesions in mice... - Is two out of three enough for ABCG1?Linda K Curtiss
Arterioscler Thromb Vasc Biol 26:2175-7. 2006 - Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in miceGary Bradshaw
Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
Proc Natl Acad Sci U S A 102:11029-34. 2005..GdCl(3)-facilated replacement of Kupffer cells may enhance the efficacy of other HSC-based gene therapies... - Apolipoprotein A-II inhibits high density lipoprotein remodeling and lipid-poor apolipoprotein A-I formationKerry Anne Rye
Lipid Research Laboratory, Hanson Institute, Adelaide, South Australia 5000, Australia
J Biol Chem 278:22530-6. 2003.... - Evidence that phospholipids play a key role in pre-beta apoA-I formation and high-density lipoprotein remodelingKerry Anne Rye
Lipid Research Laboratory, Hanson Institute, Adelaide, South Australia, Australia 5000
Biochemistry 41:12538-45. 2002..In conclusion, these results show that phospholipids play a key role in the CETP-mediated remodeling of rHDL and pre-beta apoA-I formation... - Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and betaPuiying A Mak
Department of Biological Chemistry and Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 277:31900-8. 2002..These results suggest an alternative mechanism by which lipids are removed from macrophage foam cells... - Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesisPeter Tobias
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Lipid Res 46:404-11. 2005..In this review, we discuss our current understanding of the role of TLRs and their coactivators in atherosclerosis, with particular emphasis on studies in atherosclerosis-prone hypercholesterolemic mice...
Research Grants
- IMMUNOBIOLOGY OF APOLIPOPROTEIN ELinda Curtiss; Fiscal Year: 2002..abstract_text> ..
- IMMUNOCHEMICAL STRUCTURE FUNCTION OF APOLIPOPROTEIN A-ILinda Curtiss; Fiscal Year: 2003..abstract_text> ..
- Atherosclerosis in Beige(Lyst) MutantLinda Curtiss; Fiscal Year: 2006..The power of comparing LDLr- /-bg with LDLr-/- mice will allow us to focus on those cellular activities that are physiologically relevant and participate in vivo in a very complex and still poorly understood disease process. ..
- Blood System in Coagulation and Vessel DiseaseLinda Curtiss; Fiscal Year: 2007..End of Abstract) ..
- Toll Receptors in AtherosclerosisLinda Curtiss; Fiscal Year: 2007..These studies will enhance our understanding of inflammatory responses in atherosclerosis and potentially identify new TLR targets for therapeutic intervention to reverse or reduce disease risk. ..
- IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-ILinda Curtiss; Fiscal Year: 2007..We propose that core lipid reduction by triglyceride hydrolysis and remodeling by PLTP and CETP release lipid-poor apoAI from HDL to facilitate efflux from Mphi foam cells within atherosclerotic lesions. ..
- IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN AILinda Curtiss; Fiscal Year: 1999....
- IMMUNOBIOLOGY OF APOLIPOPROTEIN ELinda Curtiss; Fiscal Year: 1993..Finally, the structural regions of apo E that are responsible for its inhibitory activity will be identified using monoclonal antibodies and synthetic peptides...
- IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-ILinda Curtiss; Fiscal Year: 1993....