Linda Columbus

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Mapping backbone dynamics in solution with site-directed spin labeling: GCN4-58 bZip free and bound to DNA
    Linda Columbus
    Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-7008, USA
    Biochemistry 43:7273-87. 2004
  2. ncbi NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima
    Linda Columbus
    Joint Center of Structural Genomics and Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Proteins 60:552-7. 2005
  3. ncbi Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination
    Linda Columbus
    The Joint Center for Structural Genomics and The Scripps Research Institute, Department of Molecular Biology, La Jolla, California 92037, USA
    Protein Sci 15:961-75. 2006
  4. ncbi Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation
    Christine Beuck
    Department of Molecular Biology, Department of Chemistry, and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Structure 18:377-89. 2010
  5. ncbi Size and shape of detergent micelles determined by small-angle X-ray scattering
    Jan Lipfert
    Departments of Physics and Applied Physics, Biophysics Program, and Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, California 94305, USA
    J Phys Chem B 111:12427-38. 2007
  6. ncbi Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634
    Clare J McCleverty
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Protein Sci 17:869-77. 2008
  7. ncbi A new spin on protein dynamics
    Linda Columbus
    Dept Chemistry and Biochemistry, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Biochem Sci 27:288-95. 2002

Collaborators

Detail Information

Publications7

  1. ncbi Mapping backbone dynamics in solution with site-directed spin labeling: GCN4-58 bZip free and bound to DNA
    Linda Columbus
    Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-7008, USA
    Biochemistry 43:7273-87. 2004
    ..As anticipated, the backbone motions are damped in the DNA-bound state, although a gradient of motion persists with residues at the DNA-binding site being the most highly ordered, similar to those of helices on globular proteins...
  2. ncbi NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima
    Linda Columbus
    Joint Center of Structural Genomics and Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Proteins 60:552-7. 2005
  3. ncbi Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination
    Linda Columbus
    The Joint Center for Structural Genomics and The Scripps Research Institute, Department of Molecular Biology, La Jolla, California 92037, USA
    Protein Sci 15:961-75. 2006
    ..Finally, the physical characterization of the protein-detergent complexes indicates optimal solution conditions for further structural studies for three of the eight overexpressed membrane proteins...
  4. ncbi Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation
    Christine Beuck
    Department of Molecular Biology, Department of Chemistry, and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Structure 18:377-89. 2010
    ..Finally, an improved model for STAR-mediated translational regulation of mRNA, based on the GLD-1 homodimerization domain structure, is presented...
  5. ncbi Size and shape of detergent micelles determined by small-angle X-ray scattering
    Jan Lipfert
    Departments of Physics and Applied Physics, Biophysics Program, and Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, California 94305, USA
    J Phys Chem B 111:12427-38. 2007
    ..50 and 250, respectively. Combined, these data provide a comprehensive view of the determinants of micelle formation and serve as a starting point to correlate detergent properties with detergent-protein interactions...
  6. ncbi Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634
    Clare J McCleverty
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Protein Sci 17:869-77. 2008
    ..Two different putative ligand binding sites, in which PEG200 and Co(2+) were located, were identified using crystallography and NMR, respectively...
  7. ncbi A new spin on protein dynamics
    Linda Columbus
    Dept Chemistry and Biochemistry, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Biochem Sci 27:288-95. 2002
    ....