Research Topics
| Gary ClaymanSummaryAffiliation: The University of Texas Country: USA Publications
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Detail Information
Publications
The role of neck dissection after chemoradiotherapy for oropharyngeal cancer with advanced nodal diseaseG L Clayman
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Campus Box 441, Houston, TX 77030, USA
Arch Otolaryngol Head Neck Surg 127:135-9. 2001..To analyze and compare the effectiveness of sequential platinum-based chemotherapy and radiotherapy with and without selective neck dissection in patients with N2a and greater stage node-positive squamous cell carcinoma of the oropharynx...- Approach and safety of comprehensive central compartment dissection in patients with recurrent papillary thyroid carcinomaGary L Clayman
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Head Neck 31:1152-63. 2009.... - Parathyroid carcinoma: evaluation and interdisciplinary managementGary L Clayman
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 100:900-5. 2004..D. Anderson Cancer Center (M. D. Anderson) experience are presented using the presentation of a patient to illustrate critical issues in the evaluation and interdisciplinary management of patients who are afflicted with this disease... - Medullary thyroid cancerGary L Clayman
Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 0441, Houston, TX 77030, USA
Otolaryngol Clin North Am 36:91-105. 2003..Interdisciplinary management by surgeons, endocrinologists, pathologists, radiotherapists, radiologists, and medical oncologists should be sought... - Mortality risk from squamous cell skin cancerGary L Clayman
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 23:759-65. 2005..To identify nonmelanoma skin cancer patients with squamous cell carcinoma (SCC) who are at greatest risk of disease-specific mortality... - Long-term outcome of comprehensive central compartment dissection in patients with recurrent/persistent papillary thyroid carcinomaGary L Clayman
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Thyroid 21:1309-16. 2011.... - A phase I/II study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced T-stage nasopharyngeal carcinomaFaye M Johnson
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 63:717-24. 2005..Local recurrence remains the major reason for treatment failure in advanced T-stage NPC, especially WHO types 1 and 2. Other strategies to improve local control in these patients should be investigated... - A Phase II study of docetaxel and carboplatin as neoadjuvant therapy for nasopharyngeal carcinoma with early T status and advanced N statusFaye M Johnson
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 100:991-8. 2004..We believe that the risk-based approach examined in the current study merits further investigation... - Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapyAarti Bhatia
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Head Neck 32:829-36. 2010..The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT)... - Management of nonsinonasal neuroendocrine carcinomas of the head and neckJerry L Barker
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:2322-8. 2003.... - Intraarterial cisplatin with intravenous paclitaxel and ifosfamide as an organ-preservation approach in patients with paranasal sinus carcinomaVassiliki A Papadimitrakopoulou
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:2214-23. 2003.... - Postoperative external beam radiotherapy for differentiated thyroid cancer: outcomes and morbidity with conformal treatmentDavid L Schwartz
Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 74:1083-91. 2009..To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT)... - Lymph node metastases from cutaneous squamous cell carcinoma of the head and neckBrian A Moore
Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Laryngoscope 115:1561-7. 2005..New approaches in early identification of nodal metastases, treatment, and prevention of local recurrences and second primary malignancies are warranted... - Postoperative radiotherapy for advanced medullary thyroid cancer--local disease control in the modern eraDavid L Schwartz
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Head Neck 30:883-8. 2008..The purpose of this study is to catalog modern-era postoperative radiotherapy (external beam radiotherapy [EBRT]) outcomes for advanced medullary thyroid cancer... - Phase I/II study of docetaxel, cisplatin, and concomitant boost radiation for locally advanced squamous cell cancer of the head and neckAnne S Tsao
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 24:4163-9. 2006..Phase III trials are needed to assess the contribution of concomitant boost fractionation to chemoradiotherapy... - Phase II study of induction chemotherapy with paclitaxel, ifosfamide, and carboplatin (TIC) for patients with locally advanced squamous cell carcinoma of the head and neckDong M Shin
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 95:322-30. 2002..We also hypothesized that improved complete response (CR) rates with the induction chemotherapy may render better survival rates with subsequently delivered definitive local treatment... - Parathyroid carcinoma: a 22-year experienceNaifa L Busaidy
joint Baylor College of Medicine/The University of Texas M. D. Anderson Cancer Center Training Program in Endocrinology, Diabetes, and Metabolism, Houston, Texas, USA
Head Neck 26:716-26. 2004..A comprehensive multidisciplinary approach with surgery, radiation therapy, and medical treatment for hypercalcemia is needed to optimize patient outcome... - Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysisKenji Mitsudo
Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030-4095, USA
Biochemistry 42:3874-81. 2003..Thus, LEKTI is likely to be a major physiological inhibitor of multiple serine proteinases... - Identification of 9 genes differentially expressed in head and neck squamous cell carcinomaHernan E Gonzalez
Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Arch Otolaryngol Head Neck Surg 129:754-9. 2003..Current treatment modalities in squamous cell carcinoma of the head and neck have failed to improve survival. Advances in the discovery of novel biomarkers and targets for therapy are necessary... - Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotypeDavid I Rosenthal
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 101:2567-73. 2004..The authors reviewed their institutional experience to determine whether sinonasal neuroendocrine tumors of different histologies have distinct clinical characteristics that warrant individualized treatment approaches... - Surgical management of recurrent thyroid cancerAmy Hessel
The Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Neuroimaging Clin N Am 18:517-25, viii. 2008..The use of adjuvant therapy is dependent on the presence / absence of high risk pathologic features... - Long-term outcomes of microsurgical reconstruction for large tracheal defectsPeirong Yu
Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 117:802-8. 2011..Reconstruction of large tracheal defects has been largely unsuccessful. The purpose of this study was to review the authors' experience with microsurgical reconstruction of these defects... - Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progressionLi E Wang
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 13:6532-9. 2007..To examine the role of suboptimal DNA repair capacity (DRC) for UV light-induced DNA damage in the development of nonmelanoma skin cancer (NMSC) and tumor progression... - Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samplesMitchell J Frederick
Department of Head and Neck Surgery, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
Am J Pathol 178:548-71. 2011..The feasibility of using RPPA for developing theranostic tests to guide personalized therapy is discussed in the context of these data... - Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesisJohn L Clifford
Departments of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 8:2067-72. 2002..Our previous preliminary studies suggested suppression of some or all of the ISGF-3 proteins in skin SCC... - Predictors of level V metastasis in well-differentiated thyroid cancerMichael E Kupferman
Department of Head and Neck Surgery, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA
Head Neck 30:1469-74. 2008..D. Anderson Cancer Center for the management of metastatic well-differentiated thyroid cancer... - Fenretinide activity in retinoid-resistant oral leukoplakiaScott M Lippman
Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 12:3109-14. 2006.... - Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin AArumugam Jayakumar
Department of Head and Neck Surgery, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
Protein Expr Purif 35:93-101. 2004..Taking LEKTI6-9' as an example, the BEVS should facilitate the structure-function analysis of naturally occurring processed LEKTI forms that have physiological relevance... - Differential expression profiling of head and neck squamous carcinoma: significance in their phenotypic and biological classificationAdel K El-Naggar
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, USA
Oncogene 21:8206-19. 2002.... - Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa)Christopher J Barnes
Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cancer Ther 2:345-51. 2003.... - The successful use of sorafenib to treat pediatric papillary thyroid carcinomaSteven G Waguespack
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
Thyroid 19:407-12. 2009..Sorafenib is an orally administered multi-kinase inhibitor that has shown promise in the treatment of adults with advanced thyroid cancer, but it has not yet been studied in children with this disease... - Human tracheal reconstruction with a composite radial forearm free flap and prosthesisPeirong Yu
Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Ann Thorac Surg 81:714-6. 2006..At a 6-month follow-up the patient has normal swallowing and preoperative voice quality, and she maintains a patent, non-stented airway... - Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancerDong M Shin
Department of Thoracic/Head and Neck Medical Oncology, Diagnostic Imaging, Biostatistics, Head and Neck Surgery, and Clinical Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4095, USA
J Clin Oncol 20:364-70. 2002..Combined 13cRA, IFNalpha, and cisplatin was clinically active in extensive locally advanced disease. Each agent had independent, non-cross-resistant biologic effects in vitro, which may account for the combination's clinical activity... - Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinomaAbenaa M Brewster
Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
J Clin Oncol 25:1974-8. 2007.... - Clinical significance of distinguishing between follicular lesion and follicular neoplasm in thyroid fine-needle aspiration biopsyMichelle D Williams
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Ann Surg Oncol 16:3146-53. 2009..The purpose of this study was to evaluate a single institution's experience with indeterminate thyroid FNA results to determine if subclassification (neoplasm versus lesion) aids in identifying patients at higher risk for malignancy... - A lymph node metastatic mouse model reveals alterations of metastasis-related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell lineXin Zhang
Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Cancer 95:1663-72. 2002..The data suggest that certain alterations of metastasis-related gene expression favor invasion of oral SCC and that cell surface proteins may play major roles in the metastasis of oral SCC to the lymph nodes... - Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristicsLi E Wang
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 16:764-74. 2010..In this study, we investigated the associations between genetically determined DNA repair capacity (DRC) for removing tobacco-induced DNA adducts and risk of SCCHN and tumor characteristics... - Sorafenib potently inhibits papillary thyroid carcinomas harboring RET/PTC1 rearrangementYing C Henderson
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:4908-14. 2008..Sorafenib (Nexavar, BAY 43-9006) is a multikinase inhibitor, and in this study, we tested its effects on PTC cells carrying either mutation... - Technical refinement of ultrasound-guided transoral resection of parapharyngeal/retropharyngeal thyroid carcinoma metastasesGenevieve A Andrews
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Head Neck 33:166-70. 2011..However, limited exposure with this approach can be a challenge... - Differential responses of human papillary thyroid cancer cell lines carrying the RET/PTC1 rearrangement or a BRAF mutation to MEK1/2 inhibitorsYing C Henderson
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Arch Otolaryngol Head Neck Surg 133:810-5. 2007..Activated ERK1/2 enters the nucleus and phosphorylates a variety of transcription factors, resulting in cancer cell proliferation. The MEK1/2 inhibitors, PD98059 and U0126, have been shown to inhibit cell growth in other cancers... - An orthotopic model of papillary thyroid carcinoma in athymic nude miceSoon Hyun Ahn
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Arch Otolaryngol Head Neck Surg 134:190-7. 2008..To develop a reproducible orthotopic model of papillary thyroid carcinoma for the BRAF(V600E) mutation (GenBank NM004333) and an RET/PTC rearrangement (GenBank M31213) that recapitulates the clinical picture in humans... - Transoral resection of thyroid cancer metastasis to lateral retropharyngeal nodesThomas Shellenberger
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Head Neck 29:258-66. 2007..Therefore, a less invasive surgical approach is advantageous in resection of metastatic lateral retropharyngeal nodes... - 4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysisLi E Wang
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Invest Dermatol 127:196-205. 2007..However, there is a lack of correlation between UVB-induced b/c and 4-NQO-induced b/c in this study population. Therefore, these findings need to be verified by additional studies... - Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratificationDanielle D Elliott
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 39:15-20. 2008..We conclude that the expression of these markers (1) may play a role in a subset of thyroid tumorigenesis and anaplastic transformation and (2) can be validated for potential use in the stratification of patients for targeted therapy... - Headpin: a serpin with endogenous and exogenous suppression of angiogenesisThomas D Shellenberger
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Cancer Res 65:11501-9. 2005..Therefore, this novel serpin targets diverse mechanisms against tumor angiogenesis on which to base therapeutic strategies... - Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysisArumugam Jayakumar
Department of Head and Neck Surgery, M D Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
Arch Biochem Biophys 409:367-74. 2003..These results demonstrate that the serpin headpin possesses specificity for inhibiting lysosomal cysteine proteinases... - A prospective study of intraoperative lymphatic mapping for head and neck cutaneous melanomaSusan A Eicher
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 441, Houston, TX 77030 4009, USA
Arch Otolaryngol Head Neck Surg 128:241-6. 2002..However, the accuracy and applicability of these techniques in the head and neck have not been determined conclusively... - The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cellsZhibo Yang
Department of Molecular and Cellular Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 10:658-67. 2004.... - In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysisLi-E Wang
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
J Natl Cancer Inst 97:1822-31. 2005..CONCLUSIONS: UVB-induced mutagen sensitivity may play a role in susceptibility to NMSC but not to CMM... - Production of serpins using baculovirus expression systemsArumugam Jayakumar
Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Box 0441, Houston, TX 77030-4009, USA
Methods 32:177-84. 2004..This method should be useful as an alternative expression system for those serpins that are not purifiable when expressed using the Escherichia coli or yeast expression system... - p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomasSvetlana Bolshakov
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:228-34. 2003..Tumor aggressiveness may be attributable to other genetic changes or events that occur during tumor progression... - LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulationYing C Henderson
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
DNA Cell Biol 27:71-9. 2008..Our data suggested that an interaction exists among these transcriptional factors at the transcriptional level and provided us with information in our basic understanding of P450scc regulation... - Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylationMadelene M Coombes
Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Oncogene 22:8902-11. 2003..Together these data indicate that DNA methylation is a dominant epigenetic mark for silencing of CDKN2A in Tu159 tumor cells. Moreover, changes in DNA methylation can reset the histone code by impacting multiple H3 modifications... - Detection and molecular characterization of a novel BRAF activated domain mutation in follicular variant of papillary thyroid carcinomaLibero Santarpia
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Hum Pathol 40:827-33. 2009..The effect of this mutation on the structural formation of the protein is highlighted. Our results confirm the infrequency of BRAF (V600E) mutation in FVPTC and identify a novel (A598V) mutation of this gene... - Inhibition of the growth of papillary thyroid carcinoma cells by CI-1040Ying C Henderson
Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
Arch Otolaryngol Head Neck Surg 135:347-54. 2009.... - Small molecule c-MET inhibitor PHA665752: effect on cell growth and motility in papillary thyroid carcinomaChandrani Chattopadhyay
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Head Neck 30:991-1000. 2008..c-Met is upregulated in papillary thyroid carcinoma (PTC) and can be an attractive therapeutic target. We tested the effects of the small molecule c-met inhibitor PHA665752 in blocking c-met-dependent phenotypic effects in PTC cell lines... - Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinomaAbhijit Mazumdar
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Head Neck 31:625-34. 2009..Aurora kinase A (AURKA) is amplified with varying incidence in multiple human cancers including head and neck squamous cell carcinoma (HNSCC). We investigated whether AURKA is a potential therapeutic target in HNSCC... - MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivoYing C Henderson
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cancer Ther 9:1968-76. 2010..Our findings support the clinical evaluation of PD0325901 for patients with PTC and potentially other carcinomas with BRAF mutations... - Simultaneous reconstruction of the posterior pharyngeal wall and cervical spine with a free vascularized fibula osteocutaneous flapRoy L H Ng
Department of Plastic and Reconstructive Surgery, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Plast Reconstr Surg 109:1361-5. 2002 - High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinomaYing C Henderson
Department of Head and Neck Surgery, Pathology, and Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 15:485-91. 2009..PTC usually possesses BRAF mutation or RET/PTC rearrangements. The mutation status of patients with recurrent PTC has never been characterized in a large population... - Preoperative lateral neck ultrasonography as a long-term outcome predictor in papillary thyroid cancerMauricio A Moreno
Department of Otolaryngology, Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, USA
Arch Otolaryngol Head Neck Surg 137:157-62. 2011..To evaluate the long-term outcomes and prognostic value of our sonographically based surgical approach to the lateral neck for recurrences in papillary thyroid cancer (PTC)... - Recent advances in thyroid cancerElizabeth G Grubbs
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Curr Probl Surg 45:156-250. 2008 - Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinomaLibero Santarpia
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer 116:2974-83. 2010..Defining these alterations may lead to the identification of diagnostic and biologic markers... - BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cellsThomas D Shellenberger
Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 64:8262-70. 2004..Our findings support a hypothesis that loss of BRAK expression from tumors may facilitate neovascularization and possibly contributes to immunologic escape... - Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distributionArumugam Jayakumar
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Arch Biochem Biophys 435:89-102. 2005..Recombinant LD-1-6 specifically inhibited the trypsin activity. We conclude that N-terminal signal peptide is required for LEKTI import into ER and elements present in C-terminal domains may have a role in regulating LEKTI secretion... - Experience with heat shock protein-peptide complex 96 vaccine therapy in patients with indolent non-Hodgkin lymphomaYasuhiro Oki
Department of Lymphoma and Myeloma, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:77-83. 2007.... - The effect of cyclin D1 overexpression in human head and neck cancer cellsTorahiko Nakashima
Department of Otorhinolaryngology, Kyushu University, 3 1 1 Maidashi, 812 8582 Fukuoka, Japan
Eur Arch Otorhinolaryngol 262:379-83. 2005..These observation suggest that deregulation of cyclin D1 may reduce growth factor requirements and contribute to the resistance to some chemotherapeutic agents among head and neck cancer patients... - Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)Norman M Schechter
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
Biol Chem 386:1173-84. 2005..0 in a reaction that was rapidly reversible. These results show that LEKTI, at least in fragment form, is a potent inhibitor of rhK5 and that this protease may be a target of LEKTI in human skin... - A potential role for multiple tissue kallikrein serine proteases in epidermal desquamationCarla A Borgono
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada
J Biol Chem 282:3640-52. 2007..These findings may have clinical implications for the treatment of skin disorders in which KLK activity is elevated... - Proteolytic processing of human growth hormone by multiple tissue kallikreins and regulation by the serine protease inhibitor Kazal-Type5 (SPINK5) proteinNahoko Komatsu
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1L5
Clin Chim Acta 377:228-36. 2007..Our objective is to examine if members of a newly discovered human tissue kallikrein family (KLKs) are expressed in the pituitary and if these enzymes can cleave hGH in-vitro... - Is there a role for selective neck dissection after chemoradiation for head and neck cancer?K Thomas Robbins
J Am Coll Surg 199:913-6. 2004 - American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancerDavid G Pfister
American Society of Clinical Oncology, Alexandria, VA, VA 22314, USA
J Clin Oncol 24:3693-704. 2006.... - Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tractRyuji Yasumatsu
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Cancer 94:152-8. 2002..Serum SCC antigen may be a useful biologic marker in patients with sinonasal IP... - Elevated human tissue kallikrein levels in the stratum corneum and serum of peeling skin syndrome-type B patients suggests an over-desquamation of corneocytesNahoko Komatsu
J Invest Dermatol 126:2338-42. 2006 - Changing concepts in the surgical management of the cervical node metastasisAlfio Ferlito
Department of Otolaryngology-Head and Neck Surgery, University of Udine, Policlinico Universitario, Piazzale S. Maria della Misericordia, I-33100, Udine, Italy
Oral Oncol 39:429-35. 2003 - Management of the N0 neck--reference or preferenceWilliam I Wei
Division of Head and Neck Surgery, Otorhinolaryngology, Plastic and Reconstructive Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, Peoples Republic of China
Oral Oncol 42:115-22. 2006.... - Elective and therapeutic selective neck dissectionAlfio Ferlito
Department of Surgical Sciences, ENT Clinic, University of Udine, Policlinico Universitario, Piazzale S Maria della Misericordia, 33100 Udine, Italy
Oral Oncol 42:14-25. 2006.... - Treatment considerations for head and neck cancer in the elderlyEric M Genden
Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
J Laryngol Otol 119:169-74. 2005..The aim of this review is to examine the current literature in an attempt to develop an approach to the treatment of the elderly patient with head and neck cancer and to define the pertinent issues that require further study... - Correlation between SPINK5 gene mutations and clinical manifestations in Netherton syndrome patientsNahoko Komatsu
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
J Invest Dermatol 128:1148-59. 2008..KLK levels were significantly elevated in the SC and serum of NS patients. These data link LEKTI domain deficiency and clinical manifestations in NS patients and pinpoints to possibilities for targeted therapeutic interventions... - Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer typesAmanda Ewart-Toland
UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
Carcinogenesis 26:1368-73. 2005..The data also underline the advantages of comparative association studies involving study populations from different ethnic groups for determination of disease risk... - Recent advances in thyroid cancer.In briefElizabeth G Grubbs
Curr Probl Surg 45:149-51. 2008 - SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminasesMichael Raghunath
Department of Dermatology, University Hospital, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
J Invest Dermatol 123:474-83. 2004.... - Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implicationsSylvie Chevillard
, , Direction des Sciences du Vivant, , Fontenay-aux-Roses, France
Clin Cancer Res 10:6586-97. 2004.... - Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndromeJean Pierre Hachem
Dienst Dermatologie, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium
J Invest Dermatol 126:1609-21. 2006..These studies provide a mechanistic basis for phenotypic variations in NS, and describe compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack...
Research Grants
- Biology of Headpin (a novel serpin) in Oral CancerGary Clayman; Fiscal Year: 2006..Progress in this area could lead to development of new molecular based targets for the management of oral cancer. ..