Research Topics
| Spero R CatalandSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Immunotherapy for thrombotic thrombocytopenic purpuraSpero R Cataland
Departments of Internal Medicine and Pathology, Ohio State University College of Medicine and Public Health, Columbus, OH 43210 1240, USA
Curr Opin Hematol 12:359-63. 2005..This review focuses on recent advances in the use of immune-based therapy to treat patients with refractory and relapsing acquired thrombotic thrombocytopenic purpura...
Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenic purpuraSpero R Cataland
Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, College of Medicine and Public Health, Columbus, Ohio 43210, USA
Am J Hematol 83:911-5. 2008..These data support the hypothesis that prophylactic CSA improves the ADAMTS13 activity and may be effective at preventing relapses in patients at risk for recurrences of TTP...
Demographic and ADAMTS13 biomarker data as predictors of early recurrences of idiopathic thrombotic thrombocytopenic purpuraSpero R Cataland
Department of Medicine, Columbus, OH, USA
Eur J Haematol 83:559-64. 2009..We studied the clinical utility of demographic and ADAMTS13 biomarker data to predict the risk for exacerbation...
Cyclosporin and plasma exchange in thrombotic thrombocytopenic purpura: long-term follow-up with serial analysis of ADAMTS13 activitySpero R Cataland
Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
Br J Haematol 139:486-93. 2007..These data suggest that the efficacy of CSA is at least in part related to its suppression of the antibody inhibitor of ADAMTS13 and a subsequent improvement in ADAMTS13 activity and antigen...
Relationship between ADAMTS13 activity in clinical remission and the risk of TTP relapseMing Jin
Department of Pathology, College of Medicine, Ohio State University, Columbus, OH 43210, USA
Br J Haematol 141:651-8. 2008..Identification of low ADAMTS13 activity during clinical remission as a key risk factor for TTP relapses provides a new screening strategy to identify patients who may benefit from prophylactic therapy prior to disease relapses...
Targeting the inhibitor of ADAMTS13 in thrombotic thrombocytopenic purpuraSpero R Cataland
Division of Hematology Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Public Health, Starling Loving Hall, Columbus, OH 43210, USA
Expert Opin Pharmacother 8:437-44. 2007..More recently, immunosuppressive therapy has been used alone as prophylactic therapy to prevent recurrences of acute TTP. This review focuses on the recent developments in the use of rituximab and ciclosporin in the treatment of TTP...
Leukocytoreduction for acute leukemiaPierluigi Porcu
Department of Medicine, Division of Hematology Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Ther Apher 6:15-23. 2002..The identification of the adhesion molecules, soluble cytokines, and chemotactic ligand-receptor pairs mediating endothelial cell damage in AHL should become a priority if better outcomes are desired...
Myocardial ischemia and right ventricular dysfunction in adult patients with sickle cell diseaseSubha V Raman
Division of Cardiovascular Medicine, The Ohio State University 473 W 12th Avenue, Suite 200, Columbus, OH 43210, USA
Haematologica 91:1329-35. 2006..This study sought to characterize myocardial characteristics in adult patients with SCD...
Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemiaGuido Marcucci
Division of Hematology Oncology, Department of Medicine, and the Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA
Blood 101:425-32. 2003..The encouraging clinical and laboratory results justify the current plans for a phase 3 study in previously untreated high-risk AML (ie, age at least 60 years)...
Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpuraSpero R Cataland
Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA
Am J Hematol 86:87-9. 2011..Further longitudinal study will be required to define the risk for neurologic injury and the long-term prognosis in patients previously diagnosed with TTP...
An evaluation of cyclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpuraSpero R Cataland
Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
Br J Haematol 136:146-9. 2007..042). These data suggest that cyclosporin may have advantages over corticosteroids as an adjunct to PE therapy in the initial treatment of idiopathic TTP...
Practical issues in ADAMTS13 testing and emerging therapies in thrombotic thrombocytopenic purpuraSpero R Cataland
Department of Medicine, Ohio State University, Columbus, OH 43210, USA
Semin Hematol 48:242-50. 2011..The addition of these exciting new therapies to conventional plasma-based and/or immune modulating therapies provide hope for improved treatment outcomes for TTP patients...
Rapid determination of ADAMTS13 activity improves clinical decision-makingSpero R Cataland
Am J Hematol 82:251. 2007
