Research Topics
Genomes and Genes
| George A CalinSummaryAffiliation: The University of Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?Sang Kil Lee
RNA interference and non coding RNA Center and the Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Genome Med 2:77. 2010....- Breast cancer metastasis: a microRNA storyMassimo Negrini
Department of Experimental and Diagnostic Medicine, Interdepartment Center for Cancer Research, University of Ferrara, Via Luigi Borsari, Ferrara 44100, Italy
Breast Cancer Res 10:203. 2008..The use of miRNAs as anticancer therapeutic agents is promising, and such fine molecular studies certainly help in bringing miRNAs closer to clinical practice... - Hematopoietic differentiation: a coordinated dynamical process towards attractor stable statesNadia Felli
Department of Hematology, Oncology and Molecular Medicine Istituto Superiore di Sanità , Rome, Italy
BMC Syst Biol 4:85. 2010..We investigated the 'differentiation trajectories' of the hematopoietic system considering a genome-wide scenario... - MicroRNAs and cancer: what we know and what we still have to learnGeorge A Calin
Department of Experimental Therapeutics and Cancer Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Genome Med 1:78. 2009..ABSTRACT : A report on the Keystone Symposia on MicroRNAs and Cancer, Keystone, Colorado, USA, 10-15 June 2009... - Non-coding RNAs: identification of cancer-associated microRNAs by gene profilingJana Ferdin
Department of Animal Science Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia
Technol Cancer Res Treat 9:123-38. 2010..Based on the most important findings we discuss the possible use of miRNAs as clinical biomarkers in the management of cancer patients for diagnosis, prognosis, and response to therapy... - MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancerMaitri Y Shah
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Genome Med 3:56. 2011..These new insights into the roles of miR-221/222 in breast cancer metastasis, drug resistance and RAS pathways could potentially have applications in medical practice... - Principles of microRNA involvement in human cancersHui Ling
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Chin J Cancer 30:739-48. 2011..Also, we orient the reader to several additional reviews that may provide a deeper understanding of this new and exciting field of research... - MiR-15a and miR-16-1 cluster functions in human leukemiaGeorge A Calin
Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 105:5166-71. 2008..By examining the Gene Ontology (GO) database, a significant enrichment in cancer genes (such as MCL1, BCL2, ETS1, or JUN) that directly or indirectly affect apoptosis and cell cycle was found... - MicroRNA 29b functions in acute myeloid leukemiaRamiro Garzon
Division of Hematology and Oncology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Blood 114:5331-41. 2009..Together, the data support a tumor suppressor role for miR-29 and provide a rationale for the use of synthetic miR-29b oligonucleotides as a novel strategy to improve treatment response in AML... - MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemiaRamiro Garzon
Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Blood 111:3183-9. 2008..03; and miR-199a, P = .001, Cox regression). In conclusion, miRNA expression in AML is closely associated with cytogenetics and FLT3-ITD mutations. A small subset of miRNAs is correlated with survival... - Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibilityMilena S Nicoloso
Department of Experimental Therapeutics and the Center for RNA Interference and Non coding RNAs, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer Res 70:2789-98. 2010..Therefore, we propose that transcribed target SNPs alter miRNA gene regulation and, consequently, protein expression, contributing to the likelihood of cancer susceptibility, by a novel mechanism of subtle gene regulation... - microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survivalSimona Rossi
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Blood 116:945-52. 2010..We conclude that the 21FK score represents a useful tool for distinguishing between good-prognosis and poor-prognosis CLL patients... - Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysisTetsuya Ueda
Department of Molecular Virology, Immunology, Ohio State University, Columbus, OH 43210, USA
Lancet Oncol 11:136-46. 2010..We aimed to assess the relation between microRNA expression and progression and prognosis of gastric cancer... - Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomasGeorge A Calin
Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Cancer Cell 12:215-29. 2007..Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought... - Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genesGeorge A Calin
Departments of Experimental Therapeutics and Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Blood 114:4761-70. 2009.... - RNA inhibition, microRNAs, and new therapeutic agents for cancer treatmentRiccardo Spizzo
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Lymphoma Myeloma 9:S313-8. 2009..In this review, we focus on the possible use of miRNAs or compounds interacting with miRNAs as new therapeutic agents in cancer patients... - A microRNA expression signature of human solid tumors defines cancer gene targetsStefano Volinia
Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 103:2257-61. 2006..Our results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes... - Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancerSylwia E Wojcik
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 31:208-15. 2010.... - Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemiaMuller Fabbri
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
JAMA 305:59-67. 2011.... - MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BMuller Fabbri
Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 104:15805-10. 2007..These findings support a role of miR-29s in epigenetic normalization of NSCLC, providing a rationale for the development of miRNA-based strategies for the treatment of lung cancer... - Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradationDeepa Sampath
Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 113:3744-53. 2009..Consequently, chemotherapeutic drugs that activate miR106b could initiate a p53-independent mechanism that targets CLL cells... - MicroRNAsMuller Fabbri
Human Cancer Genetics, Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH, USA
Cancer J 14:1-6. 2008..miRNA expression levels have diagnostic and prognostic implications, and their roles as anticancer therapeutic agents is promising and currently under investigation... - MicroRNA expression and function in cancerRamiro Garzon
Department of Virology, Immunology and Human Genetics, and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Trends Mol Med 12:580-7. 2006..Here, we summarize miRNA-profiling studies in human malignancies and examine the role of miRNAs in the pathogenesis of cancer. We also discuss the implications of these findings for the diagnosis and treatment of cancer... - The role of microRNA genes in papillary thyroid carcinomaHuiling He
Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 102:19075-80. 2005..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation... - Alterations of the tumor suppressor gene ARLTS1 in ovarian cancerFabio Petrocca
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 66:10287-91. 2006.... - Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181Yuri Pekarsky
Comprehensive Cancer Center, Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 66:11590-3. 2006..Our results suggest that Tcl1 expression in CLL is, at least in part, regulated by miR-29 and miR-181 and that these microRNAs may be candidates for therapeutic agents in CLLs overexpressing Tcl1... - MicroRNAs in CancerRamiro Garzon
Department of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Annu Rev Med 60:167-79. 2009..In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer... - Regulatory mechanisms of microRNAs involvement in cancerMuller Fabbri
Ohio State University, Comprehensive Cancer Center, Columbus, OH 43210, USA
Expert Opin Biol Ther 7:1009-19. 2007..In this review, the authors analyse the regulatory mechanisms of the main miRNA genes involved in human tumourigenesis... - Beyond genomics: interpreting the 93% of the human genome that does not encode proteinsMuller Fabbri
Ohio State University, Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, 1060 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH 43210, USA
Curr Opin Drug Discov Devel 13:350-8. 2010..This review focuses on the role of ncRNAs in human carcinogenesis and describes why deciphering the function of these RNAs might lead to the development of new anticancer drugs... - Epigenetics and miRNAs in human cancerMuller Fabbri
Department of Molecular Virology, Ohio State University, Columbus, OH, USA
Adv Genet 70:87-99. 2010..The result of this epigenetic-miRNA interaction is a new layer of complexity in gene regulation, whose comprehension opens new avenues to understand human cancerogenesis and to achieve new cancer treatments... - MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseasesJulianna K Edwards
David H Koch Center, University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Cardiovasc Transl Res 3:271-9. 2010..This review focuses on the identification of aberrant posttranscriptional regulators (miRNAs and UCGs) in cancer and cardiovascular disease and addresses the applications of this work towards diagnosis and therapy... - Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implicationsSimona Rossi
Department of Experimental Therapeutics, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Mamm Genome 19:526-40. 2008..These types of studies are the first step toward discoveries leading to novel approaches for cancer therapies... - Complex patterns of altered MicroRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancerAngela N Bartley
Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, 70030, USA
Clin Cancer Res 17:7283-93. 2011..MicroRNAs are potential biomarkers and therapeutic targets and agents, but limited information on microRNAome alterations during progression in the well-known adenoma-adenocarcinoma sequence is available to guide their usage... - High-throughput profiling in the hematopoietic systemMuller Fabbri
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH, USA
Methods Mol Biol 667:79-91. 2010..These techniques provide the basis for further investigations focused on the miRNAs, which are most frequently and widely differentially expressed under the different investigated conditions... - UCbase & miRfunc: a database of ultraconserved sequences and microRNA functionCristian Taccioli
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Nucleic Acids Res 37:D41-8. 2009..The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4... - Regulation of tumor angiogenesis by EZH2Chunhua Lu
Department of Gynecologic Oncology, U T M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Cell 18:185-97. 2010..Collectively, these data support the potential for targeting ezh2 as an important therapeutic approach... - MicroRNA profiling in cancerReinhold Munker
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Clin Sci (Lond) 121:141-58. 2011..In the present review, we discuss recent advances in miRNA profiling in human cancer. We discuss both frequent and rare tumour types and give an outlook on future developments... - GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentialsEsmerina Tili
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Biological Research Tower, Columbus, OH 43210, USA
Nucleic Acids Res 38:7673-88. 2010.... - MicroRNAs in the pathogeny of chronic lymphocytic leukaemiaMilena S Nicoloso
Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, TX, USA
Br J Haematol 139:709-16. 2007..These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies... - MicroRNA gene expression deregulation in human breast cancerMarilena V Iorio
Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 65:7065-70. 2005..We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index... - MicroRNAs, ultraconserved genes and colorectal cancersSimona Rossi
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Biochem Cell Biol 42:1291-7. 2010.... - MicroRNA fingerprints during human megakaryocytopoiesisRamiro Garzon
Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 103:5078-83. 2006..Our data delineate the expression of microRNAs during megakaryocytopoiesis and suggest a regulatory role of microRNAs in this process by targeting megakaryocytic transcription factors... - MicroRNAs in the ontogeny of leukemias and lymphomasMuller Fabbri
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Leuk Lymphoma 50:160-70. 2009.... - MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancerResham Bhattacharya
Department of Biochemistry, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Res 69:9090-5. 2009..These findings suggest the development of therapeutic strategies by restoring miR-15a and miR-16 expression in ovarian cancer and in other cancers that involve upregulation of Bmi-1... - Non-coding RNAs for medical practice in oncologyTetsuro Setoyama
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Keio J Med 60:106-13. 2011..These discoveries could be exploited for the development of useful markers for diagnosis and prognosis in cancer, as well as for the development of new RNA-based cancer therapies... - Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer CellsMaria I Almeida
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
Gastroenterology 142:886-896.e9. 2012..We analyzed the expression, functions, and mechanisms of miR-28-5p and miR-28-3p in colorectal cancer (CRC) cells... - MicroRNAs--the micro steering wheel of tumour metastasesMilena S Nicoloso
Experimental Therapeutics Department, MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
Nat Rev Cancer 9:293-302. 2009.... - MicroRNA involvement in brain tumors: from bench to bedsideMilena S Nicoloso
Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
Brain Pathol 18:122-9. 2008..Furthermore, new therapeutic strategies involving miRNA silencing or miRNA mimics could be proposed based on the roles of these small non-coding RNAs as oncogenes and tumor suppressors in brain tumors... - Multiple approach to analyzing the role of microRNAs in apoptosisRiccardo Spizzo
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Methods Mol Biol 559:219-45. 2009..Our proposed method for doing this is suitable for both discovery of apoptotic pathways that regulate miRNAs and finding new miRNAs able to induce apoptosis... - MicroRNAs and genomic variations: from Proteus tricks to Prometheus giftMuller Fabbri
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, 43210, USA
Carcinogenesis 30:912-7. 2009..Furthermore, we propose that sequence variations in miRNAs or interactor sites located in mRNAs can be involved in cancer predisposition... - The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemiaGeorge A Calin
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Wiseman Hall Room 385K, 400 12th Avenue, Ohio State University, Columbus, OH 43210, USA
Best Pract Res Clin Haematol 20:425-37. 2007..Conceivably, these miRNAs might be used to target BCL2 or TCL1 for therapy of this disease... - Chromosomal rearrangements and microRNAs: a new cancer link with clinical implicationsGeorge A Calin
Department of Molecular Virology, Immunology and Medical Genetics, Colleges of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA
J Clin Invest 117:2059-66. 2007..The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci... - PDGF induced microRNA alterations in cancer cellsMinghai Shao
Department of Medicine, Indiana University School of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Nucleic Acids Res 39:4035-47. 2011..We propose that PDGF-regulated gene transcription involves alterations in non-coding RNAs and provide evidence for a miR-dependent feedback mechanism balancing growth factor receptor signaling in cancer cells... - MicroRNA signatures in human cancersGeorge A Calin
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Nat Rev Cancer 6:857-66. 2006..In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer... - Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndromeZhuang Zuo
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
Blood 118:413-5. 2011..These findings suggest that let-7a and miR-16 plasma levels can serve as noninvasive prognostic markers in MDS patients... - MicroRNAs in body fluids--the mix of hormones and biomarkersMaria Angelica Cortez
The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Nat Rev Clin Oncol 8:467-77. 2011..In addition, we explore the concept that miRNAs could function as hormones... - Potential therapeutic applications of miRNA-based technology in hematological malignanciesElisa Barbarotto
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Curr Pharm Des 14:2040-50. 2008..Here, we provide background on the biogenesis and function of miRNAs and discuss potential therapeutic applications of miRNA-based technology in hematological malignancies... - MicroRNAs: fundamental facts and involvement in human diseasesGianpiero Di Leva
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, 43210, USA
Birth Defects Res C Embryo Today 78:180-9. 2006..Furthermore, we discuss the deregulation of miRNAs in human diseases and their involvement in tumorigenesis... - OMiR: Identification of associations between OMIM diseases and microRNAsSimona Rossi
Dept of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Genomics 97:71-6. 2011..Our findings indicate that inclusion of miRNAs among the candidate genes to be considered could assist geneticists in their hunt for disease genes, particularly in the case of rare diseases... - MicroRNAs and cancer: profile, profile, profileElisa Barbarotto
Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Cancer 122:969-77. 2008..Therefore, miRNAs fingerprinting represents a new addition to the tools to be used by medical oncologists... - Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiencyNicola Zanesi
Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 65:6576-82. 2005.... - miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blastsAnna M Eiring
Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Cell 140:652-65. 2010..Altogether, these data reveal the dual ability of a microRNA to control cell fate both through base pairing with mRNA targets and through a decoy activity that interferes with the function of regulatory proteins... - MicroRNA history: Discovery, recent applications, and next frontiersMaria I Almeida
Department of Experimental Therapeutics and the Center for RNA Interference and Non coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
Mutat Res 717:1-8. 2011..In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets... - RNA interference in the clinic: challenges and future directionsChad V Pecot
U T M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Rev Cancer 11:59-67. 2011.... - miRNAs, cancer, and stem cell divisionCarlo M Croce
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Cell 122:6-7. 2005..As a cluster of recent Nature papers now show, altered expression of specific miRNA genes contributes to the initiation and progression of cancer... - Non-coding RNAs and cancer: new paradigms in oncologySang Kil Lee
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Discov Med 11:245-54. 2011..New diagnostic classifiers based on miRNAs will soon be available for medical practitioners, and even more importantly, miRNAs may become novel anti-cancer therapies... - microRNA-10b: a new marker or the marker of pancreatic ductal adenocarcinoma?Tetsuro Setoyama
Department of Experimental Therapeutics and Cancer Biology and Center for RNA Interference and Non Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 17:5527-9. 2011..If these findings are further confirmed in prospective studies, miR-10b could be used to improve the management of PDAC and decrease the mortality rate of this deadly cancer...
Research Grants
- MicroRNAs and other non-coding RNAs in Colorectal MetastasisEDMUND S KOPETZ; Fiscal Year: 2010..The final results of the described tasks will reveal new markers for molecular diagnosis and prognosis and new targets for drug therapy. ..