Research Topics
| Michael BukrinskySummaryAffiliation: The George Washington University Country: USA Publications
Research Grants
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Detail Information
Publications
How to engage CofilinMichael Bukrinsky
George Washington University, Department of Microbiology, Immunology and Tropical Medicine, Washington, DC 20037, USA
Retrovirology 5:85. 2008..I discuss implications of this study for our understanding of HIV biology and development of novel anti-HIV therapeutic approaches...- Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe)Zsigmond Benko
Children s Memorial Research Center, Departments of Pediatrics, Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Retrovirology 4:16. 2007..In this study, we further characterized molecular actions underlying the suppressive effect of Hsp16 on the Vpr activities... - Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia VirusRaymond S Weinstein
Department of Public and International Affairs, George Mason University, Manassas, VA 20110, USA
BMC Immunol 11:23. 2010.... - Cyclophilins: unexpected messengers in intercellular communicationsMichael I Bukrinsky
Department of Microbiology and Tropical Medicine, The George Washington University, Ross Hall, Room 734, 2300 Eye Street N.W, Washington, DC 20037, USA
Trends Immunol 23:323-5. 2002 - The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxisAlexander Trachtenberg
The George Washington University, Washington, DC 20037, USA
BMC Res Notes 4:396. 2011..abstract:.. - Human immunodeficiency virus infection and macrophage cholesterol metabolismMichael Bukrinsky
Department of Microbiology, Immunology and Tropical Medicine, 2300 I St, N W, Ross Hall, Rm 234, Washington, DC 20037, USA
J Leukoc Biol 80:1044-51. 2006..Further elucidation of the mechanisms connecting viral infection and macrophage cholesterol metabolism may be fruitful for developing approaches to treatment of atherosclerosis and viral diseases... - SNFing HIV transcriptionMichael Bukrinsky
The George Washington University, Department of Microbiology, Immunology and Tropical Medicine, Washington, DC 20037, USA
Retrovirology 3:49. 2006..This stimulation involves displacement of the nucleosome positioned at the HIV promoter... - Heat-shock proteins reverse the G2 arrest caused by HIV-1 viral protein RMichael Bukrinsky
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
DNA Cell Biol 23:223-5. 2004..This effect appears to be mediated by an interaction between heat shock proteins and Vpr. These results illustrate another example of antagonistic interactions between the viral and cellular proteins... - A hard way to the nucleusMichael Bukrinsky
The George Washington University Medical Center, 2300 Eye Street NW, Ross Hall Room 734, Washington, DC 20037, USA
Mol Med 10:1-5. 2004..In this review, we will discuss recent advances and suggest possible solutions to the controversial issue of HIV-1 nuclear import... - Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1Matthew P Morrow
George Washington University, Washington DC, USA
Mol Pharmacol 78:215-25. 2010..These results describe a novel approach to inhibiting HIV infection by stimulating ABCA1 expression... - Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatinSergey Iordanskiy
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
Retrovirology 3:4. 2006..Molecular details and temporal organization of these processes remain among the least investigated and most controversial problems in the biology of HIV... - Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein RSergey Iordanskiy
The George Washington University, Ross Hall Rm 734, 2300 Eye St N W, Washington, DC 20037, USA
J Virol 78:9697-704. 2004..Vpr and Hsp70 coimmunoprecipitated from HIV-infected cells. Together, these results identify Hsp70 as a novel anti-HIV innate immunity factor that targets HIV-1 Vpr... - Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infectionLarisa Dubrovsky
The George Washington University, Washington, DC, USA
Biochem Biophys Res Commun 419:95-8. 2012.... - Human immunodeficiency virus impairs reverse cholesterol transport from macrophagesZahedi Mujawar
The George Washington University, Washington, District of Columbia, USA
PLoS Biol 4:e365. 2006.... - Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophagesSergey Iordanskiy
The George Washington University, Washington, DC 20037, USA
Blood 104:1867-72. 2004..Consistent with this interpretation, Hsp70 coprecipitated with Vpr from HIV-1-infected cells... - Long-term changes of serum chemokine levels in vaccinated military personnelBeda Brichacek
Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
BMC Immunol 7:21. 2006..To investigate the influence of multiple vaccinations on innate immunity, we measured concentrations of a panel of immunomodulatory and pro-inflammatory cytokines in serum samples from a group of such individuals... - Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formationWeilin Wu
The George Washington University Medical Center, Department of Biochemistry and Molecular Biology, Washington, DC 20037, USA
Virol J 5:41. 2008..Finally, we also show that the 9AA-activated p21/waf1 is recruited to HIV-1 preintegration complex, through a mechanism yet to be elucidated... - Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix proteinOmar Haffar
International Therapeutics Inc, Seattle, Washington, USA
J Virol 79:13028-36. 2005..Compounds inhibiting HIV-1 nuclear import may be attractive candidates for further development... - CD147 stimulates HIV-1 infection in a signal-independent fashionTatiana Pushkarsky
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Ross Hall Room 734, 2300 Eye Street NW, Washington, DC 20037, USA
Biochem Biophys Res Commun 363:495-9. 2007..These results indicate that CD147 enhances HIV-1 replication in a signaling-independent fashion through specific events mediated by the cytoplasmic domain of the protein...
Research Grants
- Leukocyte recruitment by cyclophilinc-CD147 interactionMichael Bukrinsky; Fiscal Year: 2005..This exploratory proposal is fully consistent with the goals of this PA as it extends our previous discovery toward new directions related to regulation of inflammatory responses. ..
- CD4+ memory T cell recruitment by cyclophilinMichael Bukrinsky; Fiscal Year: 2004..Therefore, the R03 mechanism appears highly appropriate. If proven, this hypothesis will serve as a foundation for a new research program, which might suggest novel approaches to treatment of HIV-1 infection. ..
- The Role of Vpr in HIV-1 Nuclear TranslocationMichael Bukrinsky; Fiscal Year: 2006..These results will be significant, because they are expected to facilitate discovery of agents that would inhibit Vpr activity and thus attenuate HIV replication. ..
- HIV Impairs Reverse Cholesterol TransportMichael Bukrinsky; Fiscal Year: 2006..These studies are expected to yield sufficient information upon which to base a well-planned and rigorous series of further investigations. ..
- Oxadaizols: Rationally designed compounds targeting HIV nuclear importationMichael Bukrinsky; Fiscal Year: 2007..These studies are highly relevant to public health as they are expected to expand the repertoire of available anti-HIV drugs, thus providing an opportunity to fight drug resistance often seen in HIV-infected patients. ..
- Mechanisms of virus-induced impairment of reverse cholesterol transportMichael Bukrinsky; Fiscal Year: 2009..In addition, the proposed studies will define the mechanisms regulating physiological turnover of ABCA1 and thus may contribute to development of new therapeutic agents to treat atherosclerosis. ..
- Mechanisms of virus-induced impairment of reverse cholesterol transportDmitri Sviridov; Fiscal Year: 2010..In addition, the proposed studies will define the mechanisms regulating physiological turnover of ABCA1 and thus may contribute to development of new therapeutic agents to treat atherosclerosis. ..
- NUCLEAR TRANSLOCATION OF HIV1 GENOME AS A DRUG TARGETMichael Bukrinsky; Fiscal Year: 1999..They will analyze anti-viral effects of these compounds in different cell targets using various activation conditions. These studies are expected to lay a foundation for introducing anti-NLS compounds as new anti-HIV drugs. ..
- Imaging Technology for HIV Nuclear Import InhibitorsMichael Bukrinsky; Fiscal Year: 2003..The imaging technology will greatly augment the value of the project by adding a superior method for analyzing the activity of the drugs. ..
- NUCLEAR TRANSLOCATION OF HIV 1 GENOME AS A DRUG TARGETMichael Bukrinsky; Fiscal Year: 2004..Upon completion, these studies are expected to define potent anti-HIV compounds working through a novel mechanism different from that of any other currently used drug. ..
- HIV Disease and Impairement of High Density Lipoprotein MetabolismDmitri Sviridov; Fiscal Year: 2010..However, mechanisms connecting HIV infection and anti-HIV treatment with development of atherosclerosis are not fully understood, making proposed study highly significant both for basic science and clinical research. ..