Research Topics
Species | Robert BresalierSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activationShumei Song
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Gastroenterology 129:1581-91. 2005..Galectin-3 modulates expression of MUC2 protein, but the specific regulatory mechanisms are unknown. This study sought to determine how galectin-3 increases MUC2 expression...- Management of high-risk colonoscopy patientsRobert S Bresalier
Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1466, Houston, TX 77030 4009, USA
Gastrointest Endosc Clin N Am 20:629-40. 2010..Proper risk stratification, understanding the natural history of each disease, proper patient counseling, and optimal techniques all help define quality colonoscopy in high-risk groups... - Management of Barrett's esophagus: cases and questionsRobert Bresalier
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Semin Oncol 32:S2-5. 2005..More prospective data on disease progression and an improved knowledge of risk factors are needed to help define optimal management strategies... - Chemoprevention of colorectal cancer: why all the confusion?Robert S Bresalier
The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Curr Opin Gastroenterol 24:48-50. 2008..Findings from prospective randomized trials often conflict with those of observational studies. This review discusses some of the possible reasons based on recent clinical trials... - Barrett's Esophagus and esophageal adenocarcinomaRobert S Bresalier
Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Annu Rev Med 60:221-31. 2009.... - Barrett's Metaplasia: defining the problemRobert Bresalier
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Semin Oncol 32:21-4. 2005..In this article, the relationship between BE and gastroesophageal reflux disease, risk for adenocarcinoma, and prospects for molecular diagnosis are discussed... - A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancerRobert S Bresalier
Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 436, Houston, Texas 77030, USA
Gastroenterology 127:741-8. 2004..To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3... - Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trialRobert S Bresalier
Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
N Engl J Med 352:1092-102. 2005.... - Preoperative chemo-radiation-induced ulceration in patients with esophageal cancer: a confounding factor in tumor response assessment in integrated computed tomographic-positron emission tomographic imagingJeremy J Erasmus
Department of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Thorac Oncol 1:478-86. 2006..We evaluated the use of integrated computed tomography (CT)-PET among patients with esophageal cancer being considered for resection after CRT... - Endoscopic ultrasonography-identified celiac adenopathy remains a poor prognostic factor despite preoperative chemoradiotherapy in esophageal adenocarcinomaS Chris Malaisrie
Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Tex 77030, USA
J Thorac Cardiovasc Surg 131:65-72. 2006..These patients should be stratified in future multimodality trials. The investigation of induction chemotherapy before concurrent chemoradiotherapy might be warranted in this high-risk group of patients... - Clinical and endoscopic factors predict higher pathologic grades of Barrett dysplasiaSharmila Anandasabapathy
Department of Gastroenterology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:668-74. 2007..Identifying simple, reliable, clinical, and endoscopic predictors of high-grade dysplasia and adenocarcinoma would be helpful for risk stratification in screening and surveillance programs... - Mucins and mucin binding proteins in colorectal cancerJames C Byrd
The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
Cancer Metastasis Rev 23:77-99. 2004..Interference of the binding of selectins and galectin-3 to mucin may show therapeutic or preventative promise for colon cancer... - Diagnostic evaluation of patients with a high suspicion of malignancy: comorbidities and clinical predictors of cancerMary Ann Weiser
Department of General Internal Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Am J Med Sci 330:11-8. 2005..For some patients, diagnostic options may be limited either because of tumor location, underlying comorbid conditions, or lack of access to care... - Impact of cyclin D1 A870G polymorphism in esophageal adenocarcinoma tumorigenesisJulie G Izzo
Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Semin Oncol 32:S11-5. 2005.... - Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiationRajyalakshmi Luthra
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
J Clin Oncol 24:259-67. 2006..Currently, however, there are no tools to help select optimum therapy. We hypothesized that gene expression profiling could provide clues and biomarkers for selection of therapy... - Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activityShumei Song
Department of Gastroenterology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer Res 69:1343-9. 2009.... - Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expressionShumei Song
Department of Gastroenterology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 15:622-31. 2009..This study was designed to determine the effects of Poly E on the growth of human Barrett's and aerodigestive adenocarcinoma cells and the mechanisms involved in growth regulation by this agent... - Utility of PET, CT, and EUS to identify pathologic responders in esophageal cancerStephen G Swisher
Department of Thoracic Surgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Ann Thorac Surg 78:1152-60; discussion 1152-60. 2004.... - COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinomaShumei Song
Department of Gastrointestinal Medicine and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Gut 56:1512-21. 2007..We analysed the molecular mechanisms that govern bile acid-mediated expression of COX-2 in Barrett's oesophagus and oesophageal adenocarcinoma (OA)... - Ability of integrated positron emission and computed tomography to detect significant colonic pathology: the experience of a tertiary cancer centerBrian R Weston
Department of Gastroenterology, Hepatology and Nutrition, Unit 1466, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
Cancer 116:1454-61. 2010..The purpose of this study was to assess the ability of PET-CT to detect colonic pathology and to determine the significance of ((18)F)2-fluoro-2-deoxyglucose ((18)F-FDG) activity noted incidentally in the colon on PET-CT... - The Editor's roundtable: cyclooxygenase-2 inhibitors and cardiovascular riskRobert S Bresalier
Department of Gastrointestinal, Medicine and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Am J Cardiol 96:1589-604. 2005 - Bile acids induce MUC2 overexpression in human colon carcinoma cellsShumei Song
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA
Cancer 103:1606-14. 2005..CONCLUSIONS: Bile acids induced mucin expression in human colon carcinoma cells by increasing MUC2 transcription through a process involving MAP kinase-independent, PKC-dependent activation of AP-1... - Preface: colorectal cancerRobert S Bresalier
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Cancer Metastasis Rev 23:7-9. 2004 - Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cellsNachman Mazurek
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 282:21337-48. 2007..These findings suggest a pivotal role for P-GAL3 in promoting TRAIL sensitivity through activation of a nonclassic apoptotic pathway and identify P-GAL3 as a novel regulator of PTEN... - Value of baseline positron emission tomography for predicting overall survival in patient with nonmetastatic esophageal or gastroesophageal junction carcinomaDavid Hong
Department of GI Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 104:1620-6. 2005..Baseline NPA (> 1), reflecting the regional nodal metastases, is an independent predictor of OS. Baseline PET may become a useful stratification factor in randomized trials and for individualizing therapy... - Histologic subtypes as determinants of outcome in esophageal carcinoma patients with pathologic complete response after preoperative chemoradiotherapyPooja R Rohatgi
Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 106:552-8. 2006..CONCLUSIONS: The results of the current study suggest that the clinical biology of SCC and ACA is different after CTRT. An investigation of molecular and patient genetics is needed to improve therapy... - Phosphorylation of galectin-3 contributes to malignant transformation of human epithelial cells via modulation of unique sets of genesNachman Mazurek
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 65:10767-75. 2005..These data show the functional diversity of galectin-3 and suggest that phosphorylation of the protein is necessary for regulation (directly or indirectly) of unique sets of genes that play a role in malignant transformation... - Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosaPeter R Holt
Department of Medicine, St. Luke's/Roosevelt Hospital Center, Columbia University, New York, New York, USA
Cancer 106:287-96. 2006..CONCLUSIONS: The administration of a calcium plus vitamin D chemopreventive regimen resulted in several changes in adenomatous tissue that may have contributed to reduced polyp formation... - Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopyPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7346, USA
Clin Gastroenterol Hepatol 1:103-10. 2003..The relationship between distal and proximal colonic findings is uncertain. Thus, there is no consensus on which findings on screening flexible sigmoidoscopy should trigger colonoscopy... - Folic acid for the prevention of colorectal adenomas: a randomized clinical trialBernard F Cole
Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
JAMA 297:2351-9. 2007..Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine... - Dysplasia in Barrett esophagusChristopher D Lao
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Cancer 100:1622-7. 2004..CONCLUSIONS: The confirmed low prevalence of cases of LGD will affect the design of future clinical trials of chemopreventive interventions for Barrett esophagus... - Alternative splicing of the human MUC2 geneLawrence R Sternberg
Gastrointestinal Cancer Research Laboratory, Henry Ford Health Sciences Center, 2799 West Grand Blvd, Detroit, MI 48202, USA
Arch Biochem Biophys 421:21-33. 2004..The presence of MUC2.1 mucin may help us to explain previous conflicting reports that have attempted to correlate the relative abundance of MUC2 protein and/or mRNA with the biological behavior of colon cancer cells... - Results of repeat sigmoidoscopy 3 years after a negative examinationRobert E Schoen
Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
JAMA 290:41-8. 2003..The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain... - Expression of human intestinal mucin is modulated by the beta-galactoside binding protein galectin-3 in colon cancerSteven P Dudas
Gastrointestinal Cancer Research Laboratory, Henry Ford Health Sciences Center, Detroit, Michigan, USA
Gastroenterology 123:817-26. 2002..This may have important implications for understanding the role of galectin-3 in colon cancer metastasis... - A randomized trial of rofecoxib for the chemoprevention of colorectal adenomasJohn A Baron
Department of Medicine, The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
Gastroenterology 131:1674-82. 2006..We conducted a randomized, placebo-controlled, double-blind trial to assess whether use of the selective COX-2 inhibitor rofecoxib would reduce the risk of colorectal adenomas... - Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forwardGary J Kelloff
National Cancer Institute, Bethesda, Maryland 20852, USA
Clin Cancer Res 12:3661-97. 2006.... - Hemochromatosis gene mutations and distal adenomatous colorectal polypsKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 14:158-63. 2005..These results do not support a relationship between HFE heterozygosity and risk of advanced distal adenoma... - CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenomaLifang Hou
Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Carcinogenesis 26:1122-8. 2005..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions... - Colorectal cancer in patients under close colonoscopic surveillanceDouglas J Robertson
Section of Gastroenterology, VA Medical Center, White River Junction, Vermont 05009, USA
Gastroenterology 129:34-41. 2005..We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia... - Adherence to the USDA Food Guide, DASH Eating Plan, and Mediterranean dietary pattern reduces risk of colorectal adenomaL Beth Dixon
Department of Nutrition, Food Studies, and Public Health, New York University, New York City, NY 10012, USA
J Nutr 137:2443-50. 2007..lt;or=2 = 0.74, 95% CI = 0.55-0.99; P-trend = 0.08). Following the current U.S. dietary recommendations or a Mediterranean dietary pattern is associated with reduced risk of colorectal adenoma, especially in men... - Adherence to repeat screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening TrialJoel L Weissfeld
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Cancer 94:2569-76. 2002..In the current prospective study, the authors used adherence to repeat testing to assess the acceptability of screening flexible sigmoidoscopy... - Intestinal mucin and colorectal cancer: it's not just gooRobert S Bresalier
Gastroenterology 123:648-9. 2002 - Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugsYukinori Takenaka
Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Mol Cell Biol 24:4395-406. 2004..These results suggest that Ser(6) phosphoryaltion acts as a molecular switch for its cellular translocation from the nucleus to the cytoplasm and, as a result, regulates the antiapoptotic activity of Gal-3... - Chemoprevention of intestinal polyposis by COX-2 inhibition: from mouse to manRobert S Bresalier
Gastroenterology 122:234-6. 2002 - Calcium intake and colorectal adenoma in a US colorectal cancer early detection programUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Clin Nutr 80:1358-65. 2004..Calcium can reduce the risk of colorectal tumors by binding secondary bile and fatty acids, which leads to antiproliferative effects in the bowel, or by acting directly on the colonic epithelium, which affects differentiation and apoptosis... - Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related riskWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 15:306-11. 2006.... - Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trialJoel L Weissfeld
University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
J Natl Cancer Inst 97:989-97. 2005..Here we report findings from the baseline screening flexible sigmoidoscopy examination... - Chemoprevention of colorectal neoplasia: advances and controversies (the COX-2 story)Robert S Bresalier
Curr Opin Gastroenterol 23:44-7. 2007..Their use in other groups will depend on the answers to several questions regarding mechanisms of action and risk versus benefit...
Research Grants
- MUCIN GLYCOPROTEINS IN COLON CANCER METASTASISRobert S Bresalier; Fiscal Year: 2010..3) Determine the functional mechanism(s) by which galectin-3 modifies expression of MUC2 in colon cancer cells. ..
- MUCIN GLYCOPROTEINS IN COLON CANCER METASTASISRobert Bresalier; Fiscal Year: 2007..3) Determine the functional mechanism(s) by which galectin-3 modifies expression of MUC2 in colon cancer cells. ..
- MUCIN GLYCOPROTEINS IN COLON CANCER METASTASISRobert Bresalier; Fiscal Year: 2002..Further understanding of the roles of mucins and galectin-3 in colon cancer metastasis may make it possible to design specific diagnostic and therapeutic strategies to alter the course of metastatic disease. ..