Research Topics
Genomes and Genes
Species | Robert I BerkowitzSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
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Detail Information
Publications
Effects of sibutramine treatment in obese adolescents: a randomized trialRobert I Berkowitz
The Behavioral Health Center, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 145:81-90. 2006..Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy...- Identification of an obese eating style in 4-year-old children born at high and low risk for obesityRobert I Berkowitz
Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 18:505-12. 2010..Thus, a rapid eating style, characterized by increased mouthfuls of food/min, may be a behavioral marker for the development of childhood obesity... - Meal replacements in the treatment of adolescent obesity: a randomized controlled trialRobert I Berkowitz
Department of Child and Adolescent Psychiatry, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:1193-9. 2011..Across groups, mean reduction in BMI from baseline to month 12 was 3.4 ± 0.7% (P < 0.01). Use of MR significantly improved short-term weight loss, compared with CD, but its continued use did not improve maintenance of lost weight... - Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMIJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 59:751-5. 2010..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood... - The role of height-associated loci identified in genome wide association studies in the determination of pediatric statureJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
BMC Med Genet 11:96. 2010..Despite environmental influences, genetic factors are known to play an important role in stature determination. A number of genetic determinants of adult height have already been established through genome wide association studies... - The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMIJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:2254-7. 2009..We conclude that among 13 loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort... - Changes in symptoms of depression with weight loss: results of a randomized trialLucy F Faulconbridge
Department of Psychiatry, Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:1009-16. 2009..Further research is needed to identify characteristics of obese patients at risk of negative mood changes (and suicidal ideation) in response to behavioral and pharmacologic therapies... - Adolescent eating in the absence of hunger and relation to discretionary calorie allowanceTanja V E Kral
Division of Biostatistics, Center for Clinical Epidemiology and Biostatistics, Department of Psychiatry, Philadelphia, PA, USA
J Am Diet Assoc 110:1896-900. 2010..The association between eating in the absence of hunger and weight and obesity risk status depended on adolescents' sex and could reflect emerging developmental differences, such as dieting or social desirability... - BMD-associated variation at the Osterix locus is correlated with childhood obesity in femalesJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:1311-4. 2011..In conclusion, these findings indicate that a well established variant at the Osterix locus associated with increased BMD is also associated with childhood obesity primarily in females... - Randomized trial of lifestyle modification and pharmacotherapy for obesityThomas A Wadden
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
N Engl J Med 353:2111-20. 2005..This practice is likely to limit therapeutic benefits... - Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight geneJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 58:2414-8. 2009..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait... - Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestryStruan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:1461-5. 2009..As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs... - A two-year randomized trial of obesity treatment in primary care practiceThomas A Wadden
Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
N Engl J Med 365:1969-79. 2011..This randomized trial compared weight loss during a 2-year period in response to three lifestyle interventions, all delivered by PCPs in collaboration with auxiliary health professionals (lifestyle coaches) in their practices... - Metabolic syndrome and health-related quality of life in obese individuals seeking weight reductionAdam Gilden Tsai
Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 16:59-63. 2008..We hypothesized that MetSyn would be associated with lower HRQoL on measures of physical and mental health... - Eating in the absence of hunger: a genetic marker for childhood obesity in prepubertal boys?Myles S Faith
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Obesity (Silver Spring) 14:131-8. 2006..The primary aim of this study was to compare children born at high vs. low risk for obesity with respect to EAH at 5 years of age... - Obesity, psychiatric status, and psychiatric medicationsRobert I Berkowitz
Children s Hospital of Philadelphia, and Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, Suite 3029, Philadelphia, PA 19104, USA
Psychiatr Clin North Am 34:747-64. 2011..Persons who require antipsychotic medications are at risk for weight gain and metabolic abnormalities, and their management should be informed by consensus guidelines... - A genome-wide study reveals copy number variants exclusive to childhood obesity casesJoseph T Glessner
Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, 19104, USA
Am J Hum Genet 87:661-6. 2010..Although these variants may be individually rare, our results indicate that CNVs contribute to the genetic susceptibility of common childhood obesity in subjects of both European and African ancestry... - Beverage consumption patterns of children born at different risk of obesityTanja V E Kral
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 16:1802-8. 2008..Increased intake of sugar-sweetened beverages and fruit juice has been associated with overweight in children... - Parental feeding attitudes and styles and child body mass index: prospective analysis of a gene-environment interactionMyles S Faith
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pediatrics 114:e429-36. 2004..Parental feeding styles were linked to child weight in cross-sectional studies, which were unable to test the direction of effect. Prospective studies can best establish causal relationships among such variables... - Role of BMI-Associated Loci Identified in GWAS Meta-Analyses in the Context of Common Childhood Obesity in European AmericansJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:2436-9. 2011.... - Weight loss in obese African American and Caucasian adolescents: secondary analysis of a randomized clinical trial of behavioral therapy plus sibutramineGeraldine M Budd
Doctoral Program, College of Nursing and Health Professions, Drexel University, Philadelphia, PA 19102, USA
J Cardiovasc Nurs 22:288-96. 2007.... - Changes in obesity-related attitudes in women seeking weight reductionCanice E Crerand
Department of Psychiatry, Center for Weight and Eating Disorders, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Obesity (Silver Spring) 15:740-7. 2007..To examine changes in obesity-related attitudes in a sample of obese women who participated in either dieting or non-dieting interventions... - Maternal obesity associated with inflammation in their childrenKaren L Leibowitz
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
World J Pediatr 8:76-9. 2012.... - Growth of children at high risk of obesity during the first 6 y of life: implications for preventionRobert I Berkowitz
Departments of Psychiatry and the Division of GI and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Clin Nutr 81:140-6. 2005..The contribution of familial factors to adiposity in children is poorly understood... - The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting itThomas A Wadden
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA [corrected
Obesity (Silver Spring) 14:737-52. 2006..After Year 4, participants are offered monthly individual visits. The intervention is delivered by a multidisciplinary team that includes medical staff who monitor participants at risk of hypoglycemic episodes... - Daily food intake in relation to dietary energy density in the free-living environment: a prospective analysis of children born at different risk of obesityTanja V E Kral
University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Clin Nutr 86:41-7. 2007..Young children adjust their short-term intake in response to variations in energy density (ED; kcal/g) from preloads in laboratory studies. It remains unknown whether this compensation also occurs under free-living conditions... - Cardiovascular disease risk factor (CVDRF) associated waist circumference patterns in obese-prone childrenKaren L Leibowitz
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
Int J Pediatr Obes 4:150-9. 2009.... - One-year weight losses in the Look AHEAD study: factors associated with successThomas A Wadden
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:713-22. 2009..The lifestyle intervention was clinically effective in all subsets of an ethnically and demographically diverse population... - Weight reduction in obese adolescents with and without binge eatingChanelle T Bishop-Gilyard
Department of Child and Adolescent Psychiatry and Behavioral Science, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:982-7. 2011..0001). Findings suggest a combination of behavioral and pharmacologic therapy may produce both weight loss and improvement in BE... - Four-year weight losses in the Look AHEAD study: factors associated with long-term successThomas A Wadden
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:1987-98. 2011..e., ? 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years... - Sleep architecture and glucose and insulin homeostasis in obese adolescentsDorit Koren
Division of Pediatric Endocrinology and Diabetes, The Children s Hospital of Philadelphia, PA, USA
Diabetes Care 34:2442-7. 2011..We hypothesized that in obese adolescents, sleep disturbances would associate with altered glucose and insulin homeostasis... - Obesity, psychiatric status, and psychiatric medicationsRobert I Berkowitz
Weight and Eating Disorders Program, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
Psychiatr Clin North Am 28:39-54, vii-viii. 2005 - Dieting and the development of eating disorders in obese women: results of a randomized controlled trialThomas A Wadden
Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
Am J Clin Nutr 80:560-8. 2004..Some investigators fear that dieting may precipitate binge eating and other adverse behavioral consequences... - Maintenance of weight loss in adolescents: current status and future directionsMeghan L Butryn
Department of Psychology, Drexel University, Philadelphia, PA 19104, USA
J Obes 2010:789280. 2010..More research is needed on the management of adolescent obesity, which has been overlooked when compared with research on the treatment of obesity in children and adults... - Treatment of Comorbid Obesity and Major Depressive Disorder: A Prospective Pilot Study for their Combined TreatmentLucy F Faulconbridge
Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
J Obes 2011:870385. 2011..A larger randomized controlled trial is needed to establish the efficacy of this treatment... - Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNPStruan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
PLoS ONE 3:e1746. 2008..As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact... - Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind studyDenise E Wilfley
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Psychiatry 165:51-8. 2008..This study is the first large-scale, multisite, placebo-controlled trial to test the efficacy of sibutramine in binge eating disorder... - Great expectations: "I'm losing 25% of my weight no matter what you say"Thomas A Wadden
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Consult Clin Psychol 71:1084-9. 2003..Results are discussed in terms of the origins, clinical significance, and potential malleability of obese individuals' weight loss expectations... - Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trialRobert I Berkowitz
Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
JAMA 289:1805-12. 2003..Adolescent obesity is becoming a national public health problem. Weight-loss medications including sibutramine facilitate weight control in adults and could be used with obese adolescents in combination with behavior therapy (BT)... - Placebo response in binge eating disorderM Joy Jacobs Pilipski
UCSD Eating Disorders Treatment Center, San Diego, California, USA
Int J Eat Disord 40:204-11. 2007..The aims of this study were (1) to compare placebo responders (PRs) with nonresponders (NRs); (2) to investigate the course of BED following placebo response; and (3) to examine attributions regarding placebo response...