Research Topics
Genomes and GenesSpecies | M S BeattieSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Control of synaptic strength by glial TNFalphaEric C Beattie
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Science 295:2282-5. 2002..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...- Review of current evidence for apoptosis after spinal cord injuryM S Beattie
Department of Neuroscience, Ohio State University Medical Center, Columbus, USA
J Neurotrauma 17:915-25. 2000..It is likely that better understanding of apoptosis after SCI will lead to novel strategies for therapeutic interventions that can diminish secondary injury... - Inflammation and apoptosis: linked therapeutic targets in spinal cord injuryMichael S Beattie
Spinal Trauma and Repair STAR Laboratories, Neurobiology of Disease Institute and Department of Neuroscience, The Ohio State University Medical Center, Columbus, OH 43210, USA
Trends Mol Med 10:580-3. 2004.... - Cell death in models of spinal cord injuryMichael S Beattie
Department of Neuroscience, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
Prog Brain Res 137:37-47. 2002..Continued study of both contusion models and other new approaches to studying these mechanisms will be needed to maximize strategies for acute and chronic therapies, and for neural repair... - Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cordG E Hermann
Laboratory of Autonomic Neuroscience, Department of Neuroscience, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, Ohio 43210, USA
Neurobiol Dis 8:590-9. 2001..These results suggest that secondary injury may involve potentiation of AMPA receptor-mediated excitatory cell death by TNF(alpha)... - Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erectionG M Holmes
Department of Neuroscience, The Ohio State University, 4068 Graves Hall, 333 West Tenth Avenue, Columbus, OH 43210 1239, USA
Physiol Behav 73:59-64. 2001..These data further suggest that MT sensitive receptors are important in (1) mediating normal penile reflexes and (2) mediating the inhibitory response to TRH... - Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in ratsJohn C Gensel
STAR Laboratories, Laboratory for Neural Repair, Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
J Neurotrauma 23:36-54. 2006.... - An analysis of changes in sensory thresholds to mild tactile and cold stimuli after experimental spinal cord injury in the ratA E Lindsey
Laboratory for Neural Repair, Department of Neuroscience, Ohio State University, 333 W 10th Avenue, Columbus, OH 43214, USA
Neurorehabil Neural Repair 14:287-300. 2000..These data suggest that rats with contusion SCI may exhibit sensory alterations relevant to human spinal cord injuries... - Dissociation of the effects of nucleus raphe obscurus or rostral ventrolateral medulla lesions on eliminatory and sexual reflexesG M Holmes
Department of Neuroscience, Ohio State University, 4068 Graves Hall, 333 West Tenth Avenue, Columbus, OH 43210 1239, USA
Physiol Behav 75:49-55. 2002.... - Nucleus raphe obscurus (nRO) regulation of anorectal motility in ratsG M Holmes
Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus 43210, USA
Brain Res 759:197-204. 1997.... - Differential effects of intrathecal thyrotropin-releasing hormone (TRH) on perineal reflexes in male ratsG M Holmes
Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus 43210, USA
Physiol Behav 61:57-63. 1997..These data indicate that pudendal motoneurons, in the dorsomedial nucleus, are differentially regulated by neuropeptides present in the lumbosacral spinal cord... - Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literatureD Michele Basso
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus 43210, USA
Restor Neurol Neurosci 20:189-218. 2002..Greater axonal sparing is associated with more extensive recovery. Therefore, we identified the source and relative proportion of spared axons associated with extensive or limited locomotor recovery after SCI... - Longitudinal comparison of two severities of unilateral cervical spinal cord injury using magnetic resonance imaging in ratsGeorgeta Mihai
Department of Radiology, The Ohio State University, Columbus, Ohio, USA
J Neurotrauma 25:1-18. 2008..In future, MRI could be applied as a screening tool to either administer goal-directed therapies, or enable even group distribution, prior to therapeutic intervention for example through quantification and matching of swelling and edema... - Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microgliaRandolph N Christensen
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
J Neurosci Res 84:170-81. 2006..These findings suggest direct microglial excitation via glutamate receptor pathways. Thus, neurotransmitter release after brain or spinal cord injury might directly modulate the inflammatory response... - Descending spinal projections from the rostral gigantocellular reticular nuclei complexGerlinda E Hermann
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
J Comp Neurol 455:210-21. 2003..1998] J. Comp. Neurol. 397:458-474)... - Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the ratC E Hill
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
Exp Neurol 171:153-69. 2001..This suggests that these two descending systems show a delayed regenerative response and do extend axons into the lesion cavity and that the endogenous repair can continue for a very long time after SCI... - Inhibition of pudendal reflexes in spinal rats. Reassessing the role of serotoninG M Holmes
Department of Neuroscience, The Ohio State University, 4068 Graves Hall, 333 West Tenth Avenue, Columbus, OH 43210 1239, USA
Physiol Behav 74:57-64. 2001.... - Kainate-induced excitotoxicity is dependent upon extracellular potassium concentrations that regulate the activity of AMPA/KA type glutamate receptorsByeong Keun Ha
Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
J Neurochem 83:934-45. 2002..This study suggests that KA-induced excitotoxicity in mature CGCs is dependent upon the extracellular potassium concentration, which modulates functional expression and excitability of AMPA/KA receptors... - ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injuryMichael S Beattie
Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
Neuron 36:375-86. 2002..Together, these data suggest that the role of proNGF is to eliminate damaged cells by activating the apoptotic machinery of p75 after injury... - Telemetric monitoring of corpus spongiosum penis pressure in conscious rats for assessment of micturition and sexual function following spinal cord contusion injuryYvette S Nout
Department of Neuroscience, Laboratory of CNS Repair, and Spinal Trauma and Research (STAR) Laboratories, The Ohio State University, 333 W. 10th Avenue, Columbus, OH 43210, USA
J Neurotrauma 22:429-41. 2005..The study demonstrates that telemetric monitoring of CSP pressures in conscious rats is a valuable and reliable method for assessing recovery of autonomic function following SCI... - Alterations in eliminative and sexual reflexes after spinal cord injury: defecatory function and development of spasticity in pelvic floor musculatureYvette S Nout
Department of Neuroscience, Laboratory of CNS Repair and Spinal Trauma and Repair Laboratories, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
Prog Brain Res 152:359-72. 2006..Advances and continued improvement in the use of current animal models of spinal cord injury should encourage and increase the laboratory work devoted to this relatively neglected area of experimental spinal cord injury... - A sublethal dose of TNFalpha potentiates kainate-induced excitotoxicity in optic nerve oligodendrocytesBrandon A Miller
Department of Neuroscience, The Ohio State University, College of Medicine, 333 W. 10th Ave, Columbus, OH 43210, USA
Neurochem Res 30:867-75. 2005.... - Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regenerationCaitlin E Hill
STAR Laboratories, The Laboratory for Neural Repair, Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
Exp Neurol 190:289-310. 2004..However, GRP cell transplants did alter the morphology of CST axons toward that of growth cones, and CST fibers were found within GRP cell transplants, suggesting that GRP cells may be able to support axonal growth in vivo after injury... - Serotonergic fiber sprouting to external anal sphincter motoneurons after spinal cord contusionGregory M Holmes
Neuroscience Division, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
Exp Neurol 193:29-42. 2005.... - A simple post hoc transformation that improves the metric properties of the BBB scale for rats with moderate to severe spinal cord injuryAdam R Ferguson
Department of Psychology, Texas A and M University, College Station, Texas, USA
J Neurotrauma 21:1601-13. 2004..The transformation should be applied in a post hoc fashion to reduce variability and increase power in cases where few scores fall in upper portion of the scale... - Developmental stage of oligodendrocytes determines their response to activated microglia in vitroBrandon A Miller
Brain and Spinal Injury Center, Department of Neurological Surgery, University of California San Francisco, 1001 Potrero Ave, Building 1, Room 101, San Francisco, CA 94143, USA
J Neuroinflammation 4:28. 2007..Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the responses of OPCs and oligodendrocytes to activated microglia differ... - Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membraneAdam R Ferguson
Brain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94110, USA
J Neurosci 28:11391-400. 2008....