Chwan Li Shen

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. ncbi Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX, 79430 9097, USA
    Osteoporos Int 23:1541-52. 2012
  2. ncbi Green tea polyphenols mitigate deterioration of bone microarchitecture in middle-aged female rats
    Chwan Li Shen
    BB 198, 3601 4th Street, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Bone 44:684-90. 2009
  3. ncbi Effect of long-chain n-3 polyunsaturated fatty acid on inflammation mediators during osteoblastogenesis
    Chwan Li Shen
    Department of Pathology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Med Food 11:105-10. 2008
  4. ncbi Effects of Tai Chi on gait kinematics, physical function, and pain in elderly with knee osteoarthritis--a pilot study
    Chwan Li Shen
    Department of Pathology, School of Medicine, Texas Tech University Health Sciences Center, Texas 79430, USA
    Am J Chin Med 36:219-32. 2008
  5. ncbi Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
    BMC Complement Altern Med 10:76. 2010
  6. ncbi Green tea and bone metabolism
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    Nutr Res 29:437-56. 2009
  7. ncbi Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trial
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    BMC Musculoskelet Disord 10:110. 2009
  8. ncbi Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    J Nutr Biochem 21:968-74. 2010
  9. ncbi Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 21:1841-52. 2010
  10. ncbi Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 22:327-37. 2011

Research Grants

  1. GTP and Tai Chi for Bone Health: a Pilot Study
    Chwan Li Shen; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. ncbi Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX, 79430 9097, USA
    Osteoporos Int 23:1541-52. 2012
    ..Tai Chi exercise increased serum parathyroid hormone. GTP supplementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia...
  2. ncbi Green tea polyphenols mitigate deterioration of bone microarchitecture in middle-aged female rats
    Chwan Li Shen
    BB 198, 3601 4th Street, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Bone 44:684-90. 2009
    ....
  3. ncbi Effect of long-chain n-3 polyunsaturated fatty acid on inflammation mediators during osteoblastogenesis
    Chwan Li Shen
    Department of Pathology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Med Food 11:105-10. 2008
    ..Our investigation has corroborated that the protective action of EPA on osteoblastogenesis was mediated by the modulation of PGE(2) and the NO pathway...
  4. ncbi Effects of Tai Chi on gait kinematics, physical function, and pain in elderly with knee osteoarthritis--a pilot study
    Chwan Li Shen
    Department of Pathology, School of Medicine, Texas Tech University Health Sciences Center, Texas 79430, USA
    Am J Chin Med 36:219-32. 2008
    ....
  5. ncbi Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
    BMC Complement Altern Med 10:76. 2010
    ..This study was to evaluate the safety of 24 weeks of GTP supplementation combined with TC exercise in postmenopausal osteopenic women, along with effects on quality of life in this population...
  6. ncbi Green tea and bone metabolism
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    Nutr Res 29:437-56. 2009
    ..In general, tea and its bioactive components might decrease the risk of fracture by improving bone mineral density and supporting osteoblastic activities while suppressing osteoclastic activities...
  7. ncbi Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trial
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    BMC Musculoskelet Disord 10:110. 2009
    ....
  8. ncbi Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    J Nutr Biochem 21:968-74. 2010
    ..We conclude that GTP mitigates bone loss in a chronic inflammation-induced bone loss model by reducing oxidative stress-induced damage and inflammation...
  9. ncbi Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 21:1841-52. 2010
    ....
  10. ncbi Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 22:327-37. 2011
    ..GTP supplementation sustained microarchitecture and improved bone quality via a decrease in inflammation. Findings suggest a significant role for GTP in skeletal health of patients with chronic inflammation...
  11. ncbi Protective effect of green tea polyphenols on bone loss in middle-aged female rats
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX, 79430 9097, USA
    Osteoporos Int 19:979-90. 2008
    ....
  12. ncbi Comparison of the effects of Tai Chi and resistance training on bone metabolism in the elderly: a feasibility study
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Am J Chin Med 35:369-81. 2007
    ..In conclusion, these findings support that TC is beneficial for increasing bone formation in elderly, and long-term application is needed to substantiate the effect of TC as an alternative exercise in promotion of bone health...
  13. ncbi Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Inflamm Res 60:665-72. 2011
    ..This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation...
  14. ncbi Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acids
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Lipids 39:161-6. 2004
    ..The fact that CLA alone or in combination with other PUFA modulated PGE2 and NO production in human OC cultures suggests that these 18:2 isomers may have the potential to influence OA pathogenesis...
  15. ncbi Green tea and bone health: Evidence from laboratory studies
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    Pharmacol Res 64:155-61. 2011
    ....
  16. ncbi Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
    Br J Nutr 95:462-8. 2006
    ..These findings indicate a protective action of LC n-3 PUFA on ageing-induced bone loss in gonad-intact middle-aged male rats through a modulation of local factors and systemic calcitrophic hormones...
  17. ncbi Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, 79430, USA
    Calcif Tissue Int 88:455-63. 2011
    ..We conclude that GTP supplementation attenuates trabecular and cortical bone loss through increasing bone formation while suppressing bone resorption due to its antioxidant capacity...
  18. ncbi Short-term supplementation of COX-2 inhibitor suppresses bone turnover in gonad-intact middle-aged male rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430 9790, USA
    J Bone Miner Metab 24:461-6. 2006
    ..Such action was through modulating local factors and systemic hormones...
  19. ncbi Improvement of bone quality in gonad-intact middle-aged male rats by long-chain n-3 polyunsaturated fatty acid
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Calcif Tissue Int 80:286-93. 2007
    ....
  20. ncbi Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    J Nutr Biochem 22:673-80. 2011
    ..A combination of both showed to sustain bone microarchitecture and strength. We conclude that a protective impact of GTP and alfacalcidol in bone microarchitecture during chronic inflammation may be due to a suppression of TNF-?...
  21. ncbi Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis
    XingJia Wang
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Endocrinology 146:4202-8. 2005
    ..The present study suggests a novel mechanism in male aging involving COX2 and a potential application of the mechanism to delay the age-related decline in testosterone biosynthesis...
  22. ncbi Effects of tai chi exercise on posturography, gait, physical function and quality of life in postmenopausal women with osteopaenia: a randomized clinical study
    Ming Chien Chyu
    Department of Mechanical Engineering, Texas Tech University and Department of Pathology, Texas, USA
    Clin Rehabil 24:1080-90. 2010
    ..to evaluate the effects of tai chi exercise on risk factors for falls in postmenopausal women with osteopaenia through measurements of balance, gait, physical function and quality of life...
  23. ncbi Group and home-based tai chi in elderly subjects with knee osteoarthritis: a randomized controlled trial
    Jean Michel Brismee
    Department of Rehabilitation Sciences, School of Allied Health Sciences, Texas Tech University Health Sciences Center, Texas 79430, USA
    Clin Rehabil 21:99-111. 2007
    ..To evaluate the effects of tai chi consisting of group and home-based sessions in elderly subjects with knee osteoarthritis...
  24. ncbi A gel-based proteomic analysis of the effects of green tea polyphenols on ovariectomized rats
    Changxia Shao
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA
    Nutrition 27:681-6. 2011
    ..This may lead to understanding the mechanisms of GTPs in promoting bone health...
  25. ncbi Green Tea Polyphenols and 1-?-OH-Vitamin D(3) Attenuate Chronic Inflammation-Induced Myocardial Fibrosis in Female Rats
    Chwan Li Shen
    1 Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Med Food 15:269-77. 2012
    ..Neither 1-?-OH-vitamin D(3) nor GTPs affected lipid profiles. In summary, both 1-?-OH-vitamin D(3) administration and GTPs supplementation mitigate myocardial fibrosis through suppression of a chronic inflammation innate immune response...
  26. ncbi The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression
    XingJia Wang
    Department of Neuropsychiatry, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 190:871-8. 2006
    ..This study suggests that cAMP stimulation of MA-10 cells increases epoxygenase-generated AA metabolites and the co-action of these metabolites with PKA significantly increases StAR gene expression and steroid hormone production...
  27. ncbi Complementary and alternative exercises for management of osteoarthritis
    Ming Chien Chyu
    Graduate Healthcare Engineering, Whitacre College of Engineering, Texas Tech University, Lubbock, TX 79409, USA
    Arthritis 2011:364319. 2011
    ..Findings from the literature suggest that CAM exercises demonstrate considerable promise in the management of OA. Future studies require rigorous randomized controlled trials with larger sample sizes...
  28. ncbi The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function
    Lee T Ferris
    Department of Physiology, Texas Tech University Health Sciences Center Texas Tech University, Lubbock, TX 79409 3011, USA
    Med Sci Sports Exerc 39:728-34. 2007
    ..Previous studies using animals have demonstrated that acute and chronic exercise leads to increases in BDNF in various brain regions...
  29. ncbi Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes
    Chwan-Li Shen
    Department of Pathology, Texas Tech University, Lubbock, Texas 79409-2141, USA
    J Med Food 8:149-53. 2005
    ..The inhibitory effects of GRE on NO and PGE2 production by sow OC observed in this study suggest an important role for GRE as an anti-arthritic agent...
  30. ncbi Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants
    Chwan-Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79409, USA
    J Med Food 6:323-8. 2003
    ..The inhibitory effects of GRE on NO and PGE(2) production by sow osteoarthrotic cartilage explants observed in this study suggest an important role for GRE as an anti-arthritic agent in osteoarthrosis in the sow...
  31. ncbi Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells
    Kee-Jong Hong
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Phytother Res 18:768-70. 2004
    ....

Research Grants1

  1. GTP and Tai Chi for Bone Health: a Pilot Study
    Chwan Li Shen; Fiscal Year: 2007
    ..Significance: The study will result in a new alternative rehabilitation treatment with proven anti-osteoporotic benefits for postmenopausal women with low bone mass. ..