T V Arumugam

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. ncbi Targeting ischemic brain injury with intravenous immunoglobulin
    Thiruma V Arumugam
    Texas Tech University Health Sciences Center, Department of Pharmaceutical Sciences, School of Pharmacy, Amarillo, Texas 79106, USA
    Expert Opin Ther Targets 12:19-29. 2008
  2. ncbi Toll-like receptors in ischemia-reperfusion injury
    Thiruma V Arumugam
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Shock 32:4-16. 2009
  3. ncbi Neuroprotection in stroke by complement inhibition and immunoglobulin therapy
    T V Arumugam
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter Drive, Amarillo, TX 79106, USA
    Neuroscience 158:1074-89. 2009
  4. ncbi Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice
    Frank Haberman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD, USA
    Neuromolecular Med 9:315-23. 2007
  5. ncbi Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:14104-9. 2007
  6. ncbi Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
  7. ncbi Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes
    Tim Magnus
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci Res 85:2126-37. 2007
  8. ncbi Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 27:1519-28. 2007
  9. ncbi Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Med 12:621-3. 2006
  10. ncbi Role of T lymphocytes and interferon-gamma in ischemic stroke
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 113:2105-12. 2006

Collaborators

  • M P Mattson
  • Sung Chun Tang
  • Tim Magnus
  • Sung-Chun Tang
  • Aiwu Cheng
  • Frank Haberman
  • Mohamed R Mughal
  • Zhihong Guo
  • Dong Gyu Jo
  • Gokhan Yilmaz
  • Dong-Hoon Hyun
  • Ouyang Xin
  • Riccardo Cassiani-Ingoni
  • Haipeng Xue
  • Qian sheng Yu
  • Louis DeTolla
  • Seung Kwak
  • Dominic A Siler
  • Qian-sheng Yu
  • Mahendra S Rao
  • Huai Ping Ling
  • Harold W Holloway
  • Simonetta Camandola
  • Cathleen Gonzales
  • D Mark Eckley
  • Xin Ouyang
  • Rina G Khatri
  • Khadija Mustafa
  • Turhan Coksaygan
  • Justin D Lathia
  • Robert J Mark
  • Xiangru Xu
  • Srinivasulu Chigurupati
  • Roy G Cutler
  • Dong-Gyu Jo
  • Thomas Korn
  • Huai-Ping Ling
  • Dong Hoon Hyun
  • Dong Liu
  • Nigel H Greig
  • Karen Y Stokes
  • D Neil Granger

Detail Information

Publications10

  1. ncbi Targeting ischemic brain injury with intravenous immunoglobulin
    Thiruma V Arumugam
    Texas Tech University Health Sciences Center, Department of Pharmaceutical Sciences, School of Pharmacy, Amarillo, Texas 79106, USA
    Expert Opin Ther Targets 12:19-29. 2008
    ..Intravenous immunoglobulin (IVIG) is a therapeutic modality approved for the treatment of autoimmune disorders...
  2. ncbi Toll-like receptors in ischemia-reperfusion injury
    Thiruma V Arumugam
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Shock 32:4-16. 2009
    ..A greater understanding of the role of TLRs in I/R injuries may aid in the development of specific TLR-targeted therapeutics to treat these conditions...
  3. ncbi Neuroprotection in stroke by complement inhibition and immunoglobulin therapy
    T V Arumugam
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter Drive, Amarillo, TX 79106, USA
    Neuroscience 158:1074-89. 2009
    ..The striking neuroprotective actions of IVIG in animal models of ischemic stroke suggest a potential therapeutic potential that merits consideration for clinical trials in stroke patients...
  4. ncbi Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice
    Frank Haberman
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD, USA
    Neuromolecular Med 9:315-23. 2007
    ..These findings suggest a therapeutic potential for soluble analogs of uric acid in the treatment of stroke and related neurodegenerative conditions...
  5. ncbi Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:14104-9. 2007
    ..Our data suggest a major role for complement-mediated cell death in ischemic brain injury and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke...
  6. ncbi Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
    ..Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death...
  7. ncbi Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes
    Tim Magnus
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci Res 85:2126-37. 2007
    ..In contrast, neural stem cells and neuronal progenitor cells appear to play only a minor role in the injured adult CNS...
  8. ncbi Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 27:1519-28. 2007
    ..Thus, pancortin-2 is a mediator of ischemia-induced apoptosis of neurons in the adult cerebral cortex and functions in a novel mitochondrial/actin-associated protein complex that sequesters Bcl-xL...
  9. ncbi Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Med 12:621-3. 2006
    ..These findings suggest that Notch signaling may be a therapeutic target for treatment of stroke and related neurodegenerative conditions...
  10. ncbi Role of T lymphocytes and interferon-gamma in ischemic stroke
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 113:2105-12. 2006
    ....