K A Jones

Summary

Affiliation: Synaptic Pharmaceutical Corporation
Country: USA

Publications

  1. ncbi Signal transduction by GABA(B) receptor heterodimers
    K A Jones
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Neuropsychopharmacology 23:S41-9. 2000
  2. ncbi GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
    K A Jones
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Nature 396:674-9. 1998
  3. ncbi Identification and characterization of two G protein-coupled receptors for neuropeptide FF
    J A Bonini
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 275:39324-31. 2000
  4. ncbi Cloning and characterization of the human galanin GALR2 receptor
    B Borowsky
    Department of Molecular Biology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Peptides 19:1771-81. 1998
  5. ncbi Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels
    K E Smith
    Departments of Molecular Biology and Pharmacology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 273:23321-6. 1998
  6. ncbi Trace amines: identification of a family of mammalian G protein-coupled receptors
    B Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Proc Natl Acad Sci U S A 98:8966-71. 2001
  7. ncbi An in situ hybridization study of the distribution of the GABA(B2) protein mRNA in the rat CNS
    M M Durkin
    Department of Pharmacology, Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, NJ 07652, USA
    Brain Res Mol Brain Res 71:185-200. 1999
  8. ncbi Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover
    K E Smith
    Department of Molecular Biology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 272:24612-6. 1997
  9. ncbi Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cells
    M C Seeds
    Departments of Internal Medicine Section on Pulmonary and Critical Care, Pathology, and Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Respir Cell Mol Biol 23:37-44. 2000
  10. ncbi The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
    M E Garber
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    Genes Dev 12:3512-27. 1998

Collaborators

Detail Information

Publications28

  1. ncbi Signal transduction by GABA(B) receptor heterodimers
    K A Jones
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Neuropsychopharmacology 23:S41-9. 2000
    ..The interdependent nature of the two subunits for receptor function makes the GABA(B) receptor a useful model to explore the larger significance of GPCR dimerization for G-protein activation...
  2. ncbi GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
    K A Jones
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Nature 396:674-9. 1998
    ..We have now shown that co-expression of two GPCR structures, GABA(B)R1 and GABA(B)R2, belonging to the same subfamily is essential for signal transduction by GABA(B) receptors...
  3. ncbi Identification and characterization of two G protein-coupled receptors for neuropeptide FF
    J A Bonini
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 275:39324-31. 2000
    ..The identification of NPFF1 and NPFF2 will help delineate their roles in these and other physiological functions...
  4. ncbi Cloning and characterization of the human galanin GALR2 receptor
    B Borowsky
    Department of Molecular Biology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Peptides 19:1771-81. 1998
    ..A weak GALR2 mRNA signal was detected in human retina, and no signal was detected in cerebral cortex, lung, spleen, stomach, or pituitary...
  5. ncbi Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels
    K E Smith
    Departments of Molecular Biology and Pharmacology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 273:23321-6. 1998
    ..These data confirm the functional efficacy of GALR3 receptors and further suggest that GALR3 signaling pathways resemble those of GALR1 in that both can activate potassium channels linked to the regulation of neurotransmitter release...
  6. ncbi Trace amines: identification of a family of mammalian G protein-coupled receptors
    B Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Proc Natl Acad Sci U S A 98:8966-71. 2001
    ..The identification of this family of receptors should rekindle the investigation of the roles of trace amines in mammalian nervous systems and may potentially lead to the development of novel therapeutics for a variety of indications...
  7. ncbi An in situ hybridization study of the distribution of the GABA(B2) protein mRNA in the rat CNS
    M M Durkin
    Department of Pharmacology, Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, NJ 07652, USA
    Brain Res Mol Brain Res 71:185-200. 1999
    ..However, differences between GABA(B2) expression levels and GABA(B) binding sites were observed in the basal ganglia...
  8. ncbi Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover
    K E Smith
    Department of Molecular Biology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 272:24612-6. 1997
    ....
  9. ncbi Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cells
    M C Seeds
    Departments of Internal Medicine Section on Pulmonary and Critical Care, Pathology, and Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Respir Cell Mol Biol 23:37-44. 2000
    ....
  10. ncbi The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
    M E Garber
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    Genes Dev 12:3512-27. 1998
    ..Although overexpression of hCycT1 in NIH3T3 cells strongly enhances transcription from an integrated proviral promoter, we find that this fails to overcome all blocks to productive HIV-1 infection in murine cells...
  11. ncbi A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
    P Wei
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    Cell 92:451-62. 1998
    ..Moreover, overexpression of human cyclin T rescues Tat activity in nonpermissive rodent cells. We propose that Tat directs cyclin T-CDK9 to RNAPII through cooperative binding to TAR RNA...
  12. ncbi Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity
    W B Church
    The Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Sydney, NSW 2010, Australia
    Protein Eng 15:313-23. 2002
    ..Our model supports previous reports of Phe282 of hGALR1 interacting with Trp2 of galanin and His264 of hGALR1 interacting with Tyr9 of galanin...
  13. ncbi Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1
    M A Brown
    Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 92:4362-6. 1995
    ..Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35...
  14. ncbi Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants
    P Werner
    Glaxo Institute for Molecular Biology S A, Plan les Ouates, Geneva, Switzerland
    Brain Res Mol Brain Res 26:233-41. 1994
    ..Their properties are very similar to those of 5-HT3 receptors in mouse neuroblastoma cell lines...
  15. ncbi Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter
    P L Sheridan
    Salk Institute for Biological Studies, La Jolla, California 92037
    J Biol Chem 270:4575-87. 1995
    ..These findings suggest that HIP116 might affect transcription, directly or indirectly, by acting as a DNA binding site-specific ATPase...
  16. ncbi Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34
    K A Jones
    Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London
    Ann Hum Genet 57:195-201. 1993
    ..This mapping position was confirmed by PCR on a panel of translocation hybrids...
  17. ncbi Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II
    H Okamoto
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 93:11575-9. 1996
    ..These results suggest that effects of Tat on the processivity of RNA polymerase II require proteins that are associated with the CTD and may result in the phosphorylation of the CTD...
  18. ncbi Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
    A V Tutter
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 15:3342-54. 2001
    ..We conclude that the CT-ARM region of beta-catenin functions as a chromatin-specific activation domain, and that several inhibitors of the Wnt/Wg pathway directly modulate LEF-1-beta-cat activity on chromatin...
  19. ncbi Calcium sensitization produced by G protein activation in airway smooth muscle
    H Yoshimura
    Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Lung Cell Mol Physiol 281:L631-8. 2001
    ....
  20. ncbi Comparison of two murine models of familial hypertrophic cardiomyopathy
    B K McConnell
    Cardiovascular Division and Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circ Res 88:383-9. 2001
    ..These data suggest that both electrophysiological and cardiac function studies may enable more definitive risk stratification in FHC patients...
  21. ncbi Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin
    C T Sheline
    Salk Institute, La Jolla, California 92037
    Genes Dev 5:2508-20. 1991
    ..These findings suggest that the TAR element is recognized by two different nuclear RNA-binding proteins that affect transcriptional regulation by Tat...
  22. ncbi The effects of ethanol on CA(2+) sensitivity in airway smooth muscle
    M Hanazaki
    Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesth Analg 92:767-74. 2001
    ..However, unlike volatile anesthetics, ethanol causes a net increase in force through a process not dependent on protein phosphorylation, an action favoring bronchoconstriction...
  23. ncbi Functional selectivity of recombinant mammalian SWI/SNF subunits
    S Kadam
    Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 14:2441-51. 2000
    ....
  24. ncbi CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA
    M E Garber
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 20:6958-69. 2000
    ..Taken together, these results demonstrate that CDK9 phosphorylation is required for high-affinity binding of Tat-P-TEFb to TAR RNA and that the state of P-TEFb phosphorylation may regulate Tat transactivation in vivo...
  25. ncbi HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1
    J Zhang
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 275:34314-9. 2000
    ..We conclude that TAR RNA nucleates the formation of the Tat.P-TEFb complex through an induced fit mechanism...
  26. ncbi Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
    B K McConnell
    Department of Genetics, Howard Hughes Medical Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1235-44. 1999
    ..We also propose that mice bearing homozygous familial hypertrophic cardiomyopathy-causing mutations may provide useful tools for predicting the severity of disease that these mutations will cause in humans...
  27. ncbi The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1
    Y Lin
    Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genomics 27:381-2. 1995
  28. ncbi The strain variation and virulence of granulovirus of diamondback moth (Plutella xylostella Linnaeus, Lep., Yponomeutidae) isolated in Kenya
    Mark Parnell
    Natural Resources Institute, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK
    J Invertebr Pathol 79:192-6. 2002