Research Topics
| Rosemary RochfordSummaryAffiliation: SUNY Upstate Medical University Country: USA Publications
Research Grants
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Detail Information
Publications
Endemic Burkitt's lymphoma: a polymicrobial disease?Rosemary Rochford
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA
Nat Rev Microbiol 3:182-7. 2005..New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis...- Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in childrenAmolo S Asito
School of Pure and Applied Science, Kenyatta University, Nairobi, Kenya
Malar J 7:238. 2008..The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype... - Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control studyAmolo S Asito
SUNY Upstate Medical University, Syracuse, NY, USA
Infect Agent Cancer 5:13. 2010..abstract:.. - In vivo activation of toll-like receptor-9 induces an age-dependent abortive lytic cycle reactivation of murine gammaherpesvirus-68Catherine Ptaschinski
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Viral Immunol 23:547-55. 2010..These data suggest that stimulation of TLR9 differentially modulates gammaherpesvirus latency via an age-dependent mechanism... - Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of KenyaErwan Piriou
SUNY Upstate Medical University, Syracuse, New York 13210, USA
J Med Virol 81:1088-93. 2009..These data suggest that chronic exposure to malaria may lead to long-term EBV reactivation... - KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis in vitro and in vivoWilliam Wu
Department of Microbiology and Immunology, State University New York (SUNY) Upstate Medical University, Syracuse, NY, USA
Blood 108:141-51. 2006..CD34+ HPCs may be a reservoir for KSHV infection and may provide a continuous source of virally infected cells in vivo... - Infection of neonates with murine gammaherpesvirus 68 results in enhanced viral persistence in lungs and absence of infectious mononucleosis syndromeCatherine Ptaschinski
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Gen Virol 89:1114-21. 2008..Together, these data suggest that the pathogenesis of murine gammaherpesvirus gammaHV-68 is age-dependent... - Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cellsPrabal Banerjee
Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
J Virol 81:1690-700. 2007.... - Family environment is associated with endemic Burkitt lymphoma: a population-based case-control studyJeanette J Rainey
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Trop Med Hyg 78:338-43. 2008..12, 90% CI:1.19, 8.17) and to have at least one deceased parent (OR=3.38, 90% CI: 1.18, 9.64). Household characteristics, especially sibship relationships, may contribute to endemic Burkitt's lymphoma and therefore warrant further study... - Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturationRomana Hochreiter
Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams Sweet, Syracuse, NY, USA
J Gen Virol 88:1896-905. 2007..Taken together, these data demonstrate that gamma HV-68 infection of DCs differs depending on the maturation state of the DC. Moreover, the block in DC maturation suggests a possible immunoevasion strategy by gamma HV-68... - CD4+ T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8+ cytotoxic T cellsAaruni Khanolkar
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Immunol 170:3187-94. 2003..Finally, transwell cocultures, in which direct LCL-CD4(+) T cell contact was prevented, indicated a major role for CD4(+) T cell cytokines in the differentiation of LCL... - Inhibition of HHV-8/KSHV infected primary effusion lymphomas in NOD/SCID mice by azidothymidine and interferon-alphaWilliam Wu
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Leuk Res 29:545-55. 2005.... - Differential effects of CD28 costimulation upon cytokine production by CD4+ and CD8+ T cellsRosemary Rochford
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse University, Syracuse, NY 13210, USA
Immunobiology 209:513-22. 2004..CD28-mediated costimulation promotes distinct differentiation programs in CD4+ versus CD8+ T cells... - Exposure to holoendemic malaria results in suppression of Epstein-Barr virus-specific T cell immunosurveillance in Kenyan childrenAnn M Moormann
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, 44106, USA
J Infect Dis 195:799-808. 2007..Malaria and Epstein-Barr virus (EBV) infection are cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). The mechanisms by which these pathogens predispose to eBL are not known... - Spatial distribution of Burkitt's lymphoma in Kenya and association with malaria riskJeanette J Rainey
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Trop Med Int Health 12:936-43. 2007..Although crude tribe-specific incidence rates ranged between 0.0 and 3.26, tribe was not associated with BL after controlling for malaria. These findings support the aetiologic role of intense malaria transmission intensity in BL... - Toll-like receptors, Notch ligands, and cytokines drive the chronicity of lung inflammationTracy Raymond
Immunology Program and Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
Proc Am Thorac Soc 4:635-41. 2007.... - Spatial clustering of endemic Burkitt's lymphoma in high-risk regions of KenyaJeanette J Rainey
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Int J Cancer 120:121-7. 2007.... - Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in childrenAnn M Moormann
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
J Infect Dis 191:1233-8. 2005..Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL... - Model of angiogenesis in mice with severe combined immunodeficiency (SCID) and xenoengrafted with Epstein-Barr virus-transformed B cellsNina L Woodford
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Comp Med 54:209-15. 2004..These data suggest that angiogenesis accompanies EBV-associated B-cell lymphoma development, but IL-8 is not essential for this process. Thus, the SCID mouse model is amenable to testing of anti-angiogenic factors...
Research Grants
- Effects of Malaria on EBV Persistence in ChildrenRosemary Rochford; Fiscal Year: 2007....
- Antiangiogenic Therapy for AIDS-Associated LymphomasRosemary Rochford; Fiscal Year: 2007..PROJECT NARRATIVE: The goal of the proposed research is to develop a preclinical model to test new chemotherapies for AIDS-associated lymphomas. ..
- Effects of Malaria on EBV Persistence in ChildrenRosemary Rochford; Fiscal Year: 2009....
- Effects of Malaria on EBV Persistence in ChildrenRosemary Rochford; Fiscal Year: 2010..The knowledge gained by this study will improve the understanding of the etiology of endemic BL which will ultimately allow for the design of programs aimed at the prevention of BL. ..