Research Topics
Species | CRAIG MALBONSummaryAffiliation: State University of New York Country: USA Publications
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Publications
RGS19 regulates Wnt-beta-catenin signaling through inactivation of Galpha(o)Michael E Feigin
Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 120:3404-14. 2007..However, knockdown of RGS19 by siRNA suppressed canonical Wnt signaling, suggesting a complex role for RGS19 in regulating the ability of Wnt3a to signal to the level of beta-catenin and gene transcription...- Probing the physical nature and composition of signalsomesHsien Yu Wang
Departments of Physiology and Biophysics, Health Sciences Center, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661 USA
J Mol Signal 6:1. 2011..abstract:.. - Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?C C Malbon
Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
Biochem Biophys Res Commun 287:589-93. 2001..The new data, consistent with the properties known for virtually all members of the G-protein-coupled receptors, reveal a more classic romance of signaling elements controlling aspects of early development... - Insulin signalling: putting the 'G-' in protein-protein interactionsCraig C Malbon
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine HSC, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
Biochem J 380:e11-2. 2004..Understanding the convergence and cross-talk of signals from the receptor tyrosine kinases and G-protein-coupled receptor pathways in physical, spatial and temporal contexts will remain a major challenge of cell biology... - AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexesCraig C Malbon
Department of Molecular Pharmacology, University Medical Center, Stony Brook University, Stony Brook, NY 11794 8651, USA
Biochem J 379:1-9. 2004..Dynamic regulation of the AKAP-receptor complex is mediated by ordered protein phosphorylation... - Frizzleds: new members of the superfamily of G-protein-coupled receptorsCraig C Malbon
Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
Front Biosci 9:1048-58. 2004..Recognition of the GPCR character of Frizzled enables a more broad understanding of these receptors and of their mechanisms of downstream signaling... - AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signallingC C Malbon
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine HSC, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
Biochem Soc Trans 32:861-4. 2004..The spatial dimension of the integration of cell signalling will probably reflect many functions performed by members of the AKAP family... - Beta-catenin, cancer, and G proteins: not just for frizzleds anymoreCraig C Malbon
Department of Pharmacology, School of Medicine, Health Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
Sci STKE 2005:pe35. 2005..The ability of LPA to increase the cytoplasmic and nuclear accumulation of beta-catenin provides a new dimension of knowledge linking lipid mediators to the dysregulation of beta-catenin signaling in cancer... - A-kinase anchoring proteins: trafficking in G-protein-coupled receptors and the proteins that regulate receptor biologyCraig C Malbon
Department of Pharmacology, Diabetes and Metabolic Diseases Research Program, School of Medicine, Stony Brook University, Stony Brook, NY 11794 8661, USA
Curr Opin Drug Discov Devel 10:573-9. 2007.... - AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffoldJiangchuan Tao
Department of Pharmacology, School of Medicine, Heath Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
J Mol Signal 5:3. 2010..In the current work, the AKAR2 biosensor was fused to the N-terminus of AKAP12 to evaluate its ability to function and report on dynamic phosphorylation of the AKAP12 scaffold... - Akt mediates sequestration of the beta(2)-adrenergic receptor in response to insulinSergey Doronin
Department of Molecular Pharmacology, University Medical Center, State University of New York Stony Brook, Stony Brook, New York 11794 8651, USA
J Biol Chem 277:15124-31. 2002..The action of the serine-threonine protein kinase Akt in insulin counterregulation mirrors the central role of protein kinase A in beta-agonist-induced desensitization... - pp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activationElena Shumay
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
Mol Biol Cell 13:3943-54. 2002..We report a novel positioning of Src, mediating signals from insulin to phosphatidylinositol 3-kinase and to beta(2)-adrenergic receptor trafficking... - G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cellsRama Kamesh Bikkavilli
Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 121:234-45. 2008..These data reveal both common and unique signaling elements in WNT3a-sensitive pathways, highlighting crosstalk from WNT3a-JNK to WNT3a-beta-catenin signaling... - The 15-amino acid motif of the C terminus of the beta2-adrenergic receptor is sufficient to confer insulin-stimulated counterregulation to the beta1-adrenergic receptorShai Gavi
Department of Pharmacology, University Medical Center, State University of New York Stony Brook, Stony Brook, New York 11794 8651, USA
Endocrinology 146:450-7. 2005.... - Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptorJiangchuan Tao
Departments of Pharmacology and Physiology and Biophysics, Heath Sciences Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
EMBO J 22:6419-29. 2003.... - Trafficking of beta2-adrenergic receptors: insulin and beta-agonists regulate internalization by distinct cytoskeletal pathwaysElena Shumay
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center HSC, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 117:593-600. 2004.... - Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cellsJyotshnabala Kanungo
Department of Molecular Pharmacology, University Medical Center, SUNY Stony Brook, NY 11794, USA
Biochem Biophys Res Commun 323:293-8. 2004..These results suggest that Ku80 is required for Galpha13-mediated endodermal differentiation in P19 cells... - G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formationYi-Nan Lee
Department of Physiology and Biophysics, Diabetes and Metabolic Diseases Research Center, State University of New York Stony Brook, New York 11794-8661, USA
J Biol Chem 279:54896-904. 2004..In a concerted effort, RhoA in tandem with Cdc42 and Rac1 activates the MEKK1/4, MEK1/MKK4, and JNK cascade, thereby stimulating formation of primitive endoderm... - p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3betaRama Kamesh Bikkavilli
Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 121:3598-607. 2008..We demonstrate the involvement of G-proteins and Dishevelleds in Wnt3a-induced p38 MAPK activation, highlighting a critical role for p38 MAPK in canonical Wnt-beta-catenin signaling... - Insulin stimulates phosphorylation of the beta 2-adrenergic receptor by the insulin receptor, creating a potent feedback inhibitor of its tyrosine kinaseSergey Doronin
Department of Pharmacology, Physiology and Biophysics, Diabetes and Metabolic Diseases Research Program, Health Sciences Center, State University of New York, Stony Brook, New York 11794, USA
J Biol Chem 277:10698-703. 2002.... - Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMPAdriana Ahumada
Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
Science 298:2006-10. 2002..Moreover, PDE inhibitors blocked Rfz2-induced calcium transients in zebrafish embryos. Thus, Frizzled-2 appears to couple to PDEs and calcium transients through G proteins... - G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulationShai Gavi
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Trends Endocrinol Metab 17:48-54. 2006..A broader understanding of how G-protein-coupled receptors and tyrosine kinases cross-talk reveals new insights into signaling modalities in both health and disease... - Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptorsShai Gavi
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine HSC, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Endocrinology 148:2653-62. 2007..IGF-I attenuates the ability of beta(1)-adrenergic receptors to accumulate intracellular cAMP in response to Iso and promotes internalization of beta(1)-adrenergic receptors in these cardiac myocytes... - Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cellsDezhong Yin
Department of Molecular Pharmacology, University Medical Center, SUNY/Stony Brook, Stony Brook, NY 11794-8651, USA
Biochem Biophys Res Commun 329:281-7. 2005..This is the first successful demonstration of the ability to express a functional yeast GPCR in mammalian cells... - Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4Hsien Yu Wang
Department of Physiology and Biophysics, University Medical Center, State University of New York, Stony Brook, New York 11794 8661, USA
J Biol Chem 277:3530-6. 2002.... - Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancerHsien Yu Wang
Department of Physiology and Biophysics, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8661, USA
Cancer Lett 191:229-37. 2003..Suppression of MKP activity therapeutically may enable the expression of the pro-apoptotic signals from JNK in malignant cells... - Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functionsHsien-Yu Wang
Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA
Science 300:1529-30. 2003..Wnt regulation of intracellular Ca2+ and cGMP levels requires the G protein transducin and a cGMP-specific phosphodiesterase, which are major elements in signaling of the visual pathway... - G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distributionMin Huei Chen
Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, United States
Cell Signal 21:136-42. 2009..Thus these homologous, AKAPs that dock G-protein-coupled receptors have markedly different patterns of trafficking, docking, and re-distribution... - Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalizationElena Shumay
Department of Pharmacology, Diabetes and Metabolic Diseases Research Program, School of Medicine, State University of New York, Stony Brook, New York 11794 8661, USA
J Biol Chem 282:21529-41. 2007.... - Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acidTong Liu
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, State University of New York (SUNY) at Stony Brook, Stony Brook, NY 11794-8651, USA
J Biol Chem 277:30887-91. 2002..These data reveal the obligate role of the beta-catenin/Lef-Tcf transcriptional pathway in the action of the morphogen retinoic acid... - Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cellsHong Li
Department of Pharmacology, Health Science Center, SUNY-Stony Brook, Stony Brook, NY 11794-8651, USA
Mol Pharmacol 65:45-55. 2004..We demonstrate the utility of beta2-adrenergic receptor-Frizzled chimeras to provide the tools with which to activate and to probe Frizzled-specific downstream signaling to gene activation... - Dishevelled-2 docks and activates Src in a Wnt-dependent mannerNoriko Yokoyama
Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 122:4439-51. 2009..Activated Src, in turn, enhances Wnt activation of the canonical pathway. We show that Dvl2 and beta-catenin are crucially important substrates for tyrosine phosphorylation in the canonical Wnt/beta-catenin pathway... - Regulation of AKAP-membrane interactions by calciumJiangchuan Tao
Department of Pharmacology, School of Medicine, Heath Sciences Center, State University of New York, Stony Brook, New York 11794 8651, USA
J Biol Chem 281:23932-44. 2006..Mutation of any two PCDs eliminates membrane association of the non-myristoylated gravin, the sensitivity to Ca2+/calmodulin, and the ability of this scaffold to catalyze receptor resensitization and recycling... - G-Protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin)Hsien-Yu Wang
Department of Physiology and Biophysics, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA
Eur J Cell Biol 85:643-50. 2006..Each AKAP provides a template that enables space-time continuum features to G-protein-coupled signaling pathways as well as a paradigm for explaining apparent compartmentalization of cell signaling... - Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNARama Kamesh Bikkavilli
Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Sci 123:1352-62. 2010..Thus, Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability... - The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptorAnthony J DeCostanzo
Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
Naunyn Schmiedebergs Arch Pharmacol 365:341-8. 2002.... - Inducible, tissue-specific suppression of heterotrimeric G protein alpha subunits in vivoXi-Ping Huang
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
Methods Enzymol 344:318-27. 2002 - Targeted, regulatable expression of activated heterotrimeric G protein alpha subunits in transgenic miceXiaosong Song
Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
Methods Enzymol 344:309-18. 2002 - Src docks to A-kinase anchoring protein gravin, regulating beta2-adrenergic receptor resensitization and recyclingJiangchuan Tao
Department of Pharmacology, State University of New York, Stony Brook, New York 11794 8651, USA
J Biol Chem 282:6597-608. 2007..The tyrosine kinase Src plays an essential role in the AKAP gravin-mediated receptor resensitization and recycling, an essential aspect of receptor biology... - Dishevelled: a mobile scaffold catalyzing developmentCraig C Malbon
Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Curr Top Dev Biol 72:153-66. 2006..Much excitement awaits the elucidation of the complete set of tools in the toolbox and of the dynamic regulation of Dishevelled proteins and their interacting proteins... - Targeted expression of activated Q227L G(alpha)(s) in vivoXi Ping Huang
Department of Molecular Pharmacology, Diabetes and Metabolic Diseases Research Program, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Am J Physiol Cell Physiol 283:C386-95. 2002.... - Probing receptor structure/function with chimeric G-protein-coupled receptorsDezhong Yin
Department of Molecular Pharmacology, University Medical Center, Stony Brook University, Stony Brook, New York, USA
Mol Pharmacol 65:1323-32. 2004.... - G proteins in developmentCraig C Malbon
Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
Nat Rev Mol Cell Biol 6:689-701. 2005..The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development... - OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signalingMichael E Feigin
Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, United States
Cell Signal 20:949-57. 2008....
Research Grants
- REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSCraig C Malbon; Fiscal Year: 2010..Dvls, as multivalent dynamic scaffolds, are high-value likely targets for new therapies. ..
- STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSCraig C Malbon; Fiscal Year: 2010..Alterations in scaffolds (i.e., abundance and structure) lead to disease and our research seeks to understand how these scaffolds perform their multifaceted functions. ..
- REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSCRAIG MALBON; Fiscal Year: 2005..Each of these pathways are implicated in developmental defects and cancer in humans. ..
- Cyclic GMP Phosphodiesterase in SignalingCRAIG MALBON; Fiscal Year: 2004..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..
- STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSCRAIG MALBON; Fiscal Year: 2003..abstract_text> ..
- Acquiring robotic support for mass spectrometry coreCRAIG MALBON; Fiscal Year: 2003..The institution has provided resources to enable the acquisition of two new mass spectrometers and this proposal builds on the investment. ..
- RENOVATIONS FOR CAGEWASH SUPPORT SERVICEThomas Zimmerman; Fiscal Year: 2005....
- STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSCRAIG MALBON; Fiscal Year: 2009..Alterations in scaffolds (i.e., abundance and structure) lead to disease and our research seeks to understand how these scaffolds perform their multifaceted functions. ..
- REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSCRAIG MALBON; Fiscal Year: 2009..Dvls, as multivalent dynamic scaffolds, are high-value likely targets for new therapies. ..
- THE BIOCHEMISTRY AND CELL BIOLOGY OF METABOLIC DISEASESCRAIG MALBON; Fiscal Year: 2007..The DMDRC T32 program sponsors bioethics training, career building, and planning. The DMDRC training program enjoys strong University-wide support. ..
- Atherosclerosis And Peripheral Apoliprotein E SynthesisCRAIG MALBON; Fiscal Year: 2007..These studies will provide new mechanistic information about actions of apoE on cholesterol metabolism and atherosclerosis. ..
- STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSCRAIG MALBON; Fiscal Year: 2007..Establishing the key roles of AKAP scaffolds in GPCR signaling is essential for our understanding of GPCR in normal and disease states as well as for developing novel therapeutic interventions. ..
- REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSCRAIG MALBON; Fiscal Year: 2007..Dvls, as multivalent dynamic scaffolds, are high-value likely targets for new therapies. ..
- REGULATION OF HORMONE SENSITIVE EFFECTOR SYSTEMSCRAIG MALBON; Fiscal Year: 2000..These critical studies will illuminate the role of heterotrimeric G- proteins in pathways fundamental to signaling, cell function, and human disease. ..
- REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSCRAIG MALBON; Fiscal Year: 1993..In combination, this effort provides an integrated, multifaceted approach to the study of the cell biology and regulation of G- protein-mediated transmembrane signaling...
- REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSCRAIG MALBON; Fiscal Year: 1990..These studies will aid in elucidating the biochemical basis of hormone action in normal and pathophysiological states...
- STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSCRAIG MALBON; Fiscal Year: 1993....
- STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSCRAIG MALBON; Fiscal Year: 1991..These investigations will contribute to our knowledge of the actions of thyroid hormones in the liver and their influence on insulin action...