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Genomes and Genes | R M SapolskySummaryAffiliation: Stanford University Country: USA Publications
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Publications
Cellular defenses against excitotoxic insultsR M Sapolsky
Department of Biological Sciences, Stanford University School of Medicine, Stanford, California 94305 5020, USA
J Neurochem 76:1601-11. 2001..Such an advance would help pave the way for the rational design of therapeutic interventions against necrotic insults...- Glucocorticoids and hippocampal atrophy in neuropsychiatric disordersR M Sapolsky
Departments of Biological Sciences and Neurological Sciences, Stanford University School, Stanford, CA 94305 5020, USA
Arch Gen Psychiatry 57:925-35. 2000.... - Glucocorticoids, stress, and their adverse neurological effects: relevance to agingR M Sapolsky
Department of Biological Sciences, Stanford University, CA 94305, USA
Exp Gerontol 34:721-32. 1999..This review considers the current cellular and molecular bases underlying these adverse glucocorticoid actions, and their relevance to brain aging... - Differential sensitivity of murine astrocytes and neurons from different brain regions to injuryL Xu
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
Exp Neurol 169:416-24. 2001..Antioxidant state and levels of expression of bcl-x(L) can in part account for the differential injury observed. This suggests that different protective strategies may have different efficacies depending on brain region... - Limitations in the neuroprotective potential of gene therapy with Bcl-2R G Phillips
Department of Biological Sciences, Stanford University, Stanford, CA, USA
Brain Res 859:202-6. 2000..This finding supports the view that neurotoxicity induced by 3AP is likely to have only minimal apoptotic facets. On a broader level, it suggests some limitations in the neuroprotective potential of gene therapy with Bcl-2... - Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemiaM A Yenari
Department of Neurosurgery, Stanford University, California, USA
Stroke 32:1028-35. 2001..Calbindin D28K (CaBP) is one such intracellular calcium buffer. We investigated whether CaBP overexpression is neuroprotective against transient focal cerebral ischemia... - SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborizationR Mitra
Department of Biology, Stanford University, Stanford, CA 94305, USA
Mol Psychiatry 14:847-55, 827. 2009..SK2 overexpression also reduced dendritic arborization of the amygdala neurons. Hence, SK2 is a potential gene therapy candidate molecule that can be used against stress-related neuropsychiatric disorders such as anxiety... - Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular eventsA Gupta
Department of Biological Sciences, Stanford University, 95406, Stanford, CA, USA
Brain Res 908:49-57. 2001..Thus, the neuroprotective effects of this particular gene therapy occurs within the known framework of the mechanisms of necrotic neuronal injury... - Neuroprotection with herpes simplex vectors expressing virally derived anti-apoptotic agentsM Roy
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Brain Res 901:12-22. 2001..5 whereas all genes tested can protect against heat stress. Conversely, no genes tested can protect against metabolic poisoning by cyanide. Such a study helps us to further understand the nature of apoptotic signals in different insults... - Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectorsM A Yenari
Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
Ann N Y Acad Sci 939:340-57. 2001..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future... - Gene therapy effectiveness differs for neuronal survival and behavioral performanceR G Phillips
Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020 USA
Gene Ther 8:579-85. 2001..Despite equivalent magnitude and pattern of sparing of neurons with the immediate and 1 h delay approaches, the delay animals took a significantly longer time after insult to return to normal performance... - Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectorsM A Yenari
Department of Neurology, Stanford Stroke Center, Stanford, CA, USA
Neurol Res 23:543-52. 2001..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future... - Glucocorticoids may alter antioxidant enzyme capacity in the brain: kainic acid studiesL J McIntosh
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Brain Res 791:215-22. 1998..These experiments indicate that the impairment of antioxidant enzyme defenses, particularly the hippocampal peroxidases, could be a component of GC-mediated neuroendangerment... - Quantification of neuron survival in monolayer cultures using an enzyme-linked immunosorbent assay approach, rather than by cell countingS M Brooke
Department of Biological Sciences, Stanford University, CA 94305, USA
Neurosci Lett 267:21-4. 1999..The ABTS/ELISA method was found to be a fast, reliable and objective procedure for the quantification of neurotoxicity... - Mechanisms of estrogenic protection against gp120-induced neurotoxicityS A Howard
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Exp Neurol 168:385-91. 2001..17beta-Estradiol does, however, decrease gp120-induced lipid peroxidation and accumulation of superoxide. Together the data suggest an antioxidant mechanism of estrogen protection that is independent of receptor binding... - Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damageB Hoehn
Department of Neurosurgery, Stanford University, Stanford, California 94305-5487, USA
J Cereb Blood Flow Metab 21:1303-9. 2001..Future strategies aimed at enhancing HSP72 expression after clinical stroke may be worth pursuing. The authors suggest that in the future HSP72 may be an effective treatment for stroke... - Gene therapy and the aging nervous systemW O Ogle
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Mech Ageing Dev 122:1555-63. 2001.... - Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memoryT C Dumas
Department of Biological Sciences, Stanford University, Stanford, California, USA
Hippocampus 14:701-9. 2004..The results demonstrate the power of gene delivery in the study of the neural substrates of learning and memory and suggest that mossy fiber synaptic plasticity is critical for long-term spatial memory... - Viral caspase inhibitor p35, but not crmA, is neuroprotective in the ischemic penumbra following experimental strokeJ H Sung
Department of Neurosurgery, Stanford University, School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
Neuroscience 149:804-12. 2007..Results of double immunofluorescence staining indicate that compared with neurons infected with crmA or control vectors, p35-infected neurons had less active caspase-3 expression, cytosolic cytochrome c and nuclear AIF translocation... - Interactions among glucose, lactate and adenosine regulate energy substrate utilization in hippocampal culturesT M Bliss
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Brain Res 899:134-41. 2001..These results support the idea that after hypoxia-ischemia, neurons are biased in the direction of lactate rather than glucose utilization and this is accomplished through a number of regulatory steps... - Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental strokeB Hoehn
Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, Calif 94305-5327, USA
Stroke 34:2489-94. 2003.... - Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studiesL J McIntosh
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Brain Res 791:209-14. 1998.... - Restructuring the neuronal stress response with anti-glucocorticoid gene deliveryD Kaufer
Department of Biological Sciences, Stanford University, Stanford, California, USA
Nat Neurosci 7:947-53. 2004..Our findings elucidate three principal steps in the neuronal stress-response pathway, all of which are amenable to therapeutic intervention... - Reproductive hormone profiles in captive male orangutans: implications for understanding developmental arrestA N Maggioncalda
Department of Anthropological Sciences, Stanford University, California 94305 2145, USA
Am J Phys Anthropol 109:19-32. 1999..The authors discuss the relationship between these developmental pathways and male orangutan reproductive strategies, and hypothesize about their prepubertal socioendocrine determination... - A cautionary note: the actions of adenosine agonists and antagonists may be reversed under certain conditions in primary culturesS M Brooke
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Brain Res Bull 51:307-12. 2000..We, therefore, present this paper as a cautionary note in experimenting with adenosine analogues... - Gene therapy against neurological insults: sparing neurons versus sparing functionT C Dumas
Dept of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Trends Neurosci 24:695-700. 2001..Additionally, functional sparing might depend on factors related to insult severity, neuron type involved or the step in the death cascade that is targeted... - Sleep deprivation elevates plasma corticosterone levels in neonatal ratsI S Hairston
Neurosciences Program, Department of Biological Sciences, School of Medicine, Stanford University, Stanford, CA 94305-5020, USA. Ilana.Hairston.edu
Neurosci Lett 315:29-32. 2001..These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones... - Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical culturesS A Howard
Department of Biological Sciences, Stanford University, California 94305, USA
Exp Neurol 158:164-70. 1999.... - HSV-mediated delivery of virally derived anti-apoptotic genes protects the rat hippocampus from damage following excitotoxicity, but not metabolic disruptionM Roy
Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA
Gene Ther 9:214-9. 2002..Together, the results suggest that inhibitors of various apoptotic elements are capable of protecting under acute insult conditions both in vitro and in vivo, suggesting possible future therapeutic applications... - Alzheimer's disease and some speculations about the evolution of its modifiersR M Sapolsky
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Ann N Y Acad Sci 924:99-103. 2000..We analyze this in the context of the altricial nature of new-born primates, their long period of dependency on competent maternal care, and the requirement of cognitive intactness for such competency... - Growth hormone and thyroid stimulating hormone concentrations in captive male orangutans: implications for understanding developmental arrestA N Maggioncalda
Department of Anthropological Sciences, Stanford University, California 94305 2145, USA
Am J Primatol 50:67-76. 2000.... - Inhibition of acidification rate in cultured fibroblasts by glucocorticoids. Application of silicon microphysiometry to endocrinologyD M Redish
Department of Biological Sciences, Stanford University, California
Horm Metab Res 25:264-7. 1993..We suggest that this inhibition of metabolism is secondary to the well-established inhibition of glucose transport and of protein synthesis in fibroblasts by glucocorticoids... - The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulusA Vyas
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Neuroscience 148:342-8. 2007..This report also demonstrates that toxoplasma affects emotional valence of the cat odor as indicated by altered learned fear induced by cat odor... - Reproduction and resistance to stress: when and howJ C Wingfield
Department of Biology, University of Washington, Seattle, WA 98195, USA
J Neuroendocrinol 15:711-24. 2003..Future research will provide valuable information on the biology of stress and how organisms cope. Such mechanisms would be particularly insightful as the spectre of global change continues to unfold... - Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivationS M Nair
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands
Eur J Neurosci 20:3233-43. 2004..Therefore, removal of corticosteroids triggers a specific gene expression profile in surviving dentate granule cells; key components of this profile may be associated with their survival... - Are subordinates always stressed? A comparative analysis of rank differences in cortisol levels among primatesD H Abbott
Department of Obstetrics/Gynecology, University of Wisconsin, Madison, WI 53706, USA
Horm Behav 43:67-82. 2003....