Research Topics
| NORMAN LEHMANSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy. Case reportNorman L Lehman
Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
J Neurosurg Spine 6:441-6. 2007....- Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumorsNorman L Lehman
Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
Am J Pathol 170:1793-805. 2007..This profile of misregulated mitotic APC/C substrates and regulators in malignant tumors suggests that analysis of this pathway may be diagnostically useful and represent a potentially important therapeutic target... - Synchronous subarachnoid drop metastases from a pituitary adenoma with multiple recurrences. Case reportNorman L Lehman
Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
J Neurosurg 98:1120-3. 2003..This case demonstrates that subarachnoid metastasis of a pituitary adenoma, particularly when it follows multiple operations, is not invariably widely disseminated or associated with a very poor prognosis... - Cortical ependymoma. A case report and reviewNorman L Lehman
Department of Pathology, Stanford University Medical Center, Calif 94305, USA
Pediatr Neurosurg 39:50-4. 2003..This case illustrates the importance of establishing an accurate neuropathologic tissue diagnosis of all pediatric cortical tumors... - Malignant PEComa of the skull baseNorman L Lehman
Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
Am J Surg Pathol 28:1230-2. 2004..This report describes an apparent case of a malignant PEComa of the skull base in a 49-year-old woman, a previously undescribed location for this lesion... - Recessive dystrophic epidermolysis bullosa associated with mesangioproliferative glomerulonephritis and multifocal necrotizing leucoencephalopathy of the ponsT D Lehman
Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305, U S A
Br J Dermatol 151:1266-9. 2004..Although mesangioproliferative glomerulonephritis has previously been described in association with RDEB, to our knowledge this is the first report of MNL in a patient with RDEB... - Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cellsNorman L Lehman
Department of Pathology, Stanford University, Stanford, California 94305, USA
Cell Cycle 5:1569-73. 2006..This represents a potentially important mechanism by which pRb and p53 dysfunction may contribute to tumorigenesis through the generation of genomic instability... - Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brainMohanpal S Dulai
Department of Pathology, Stanford University Medical Center, Stanford, California, USA
J Neurosurg Pediatr 5:511-7. 2010..The histopathological and clinical courses of this rare spinal papillary ependymoma exhibiting mixed ependymal and choroid plexus-like differentiation are discussed... - Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorJulie J Miller
Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 20:2410-20. 2006..The combination of a degron/E3 recognition site and an anti-ligase function in Emi1 suggests a general model for how E3 substrates evolve to become pseudosubstrate inhibitors... - Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinomaInes Gütgemann
Department of Pathology, Stanford University, Stanford, CA, USA
Mod Pathol 21:445-54. 2008..These findings represent a potentially important insight into the molecular pathway underlying ovarian carcinogenesis and provide a possible cell cycle model for the development and progression of ovarian clear cell carcinoma... - Future potential of thymidylate synthase inhibitors in cancer therapyNorman L Lehman
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Expert Opin Investig Drugs 11:1775-87. 2002.... - Early neonatal diagnosis of long-chain 3-hydroxyacyl coenzyme a dehydrogenase and mitochondrial trifunctional protein deficienciesSusan R Hintz
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, California 94304, USA
Mol Genet Metab 75:120-7. 2002..However, timely analysis and reporting of results to clinicians are essential, because these disorders can manifest in the first few days of life... - Gliosarcoma with melanocytic differentiationMohanpal S Dulai
Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
Acta Neuropathol 115:357-61. 2008.... - Screening of tissue microarrays for ubiquitin proteasome system components in tumorsNorman L Lehman
Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA
Methods Enzymol 399:334-55. 2005..In this article, we provide an introduction to the use of TMAs to study the expression of UPS component proteins and substrates in tumors by immunohistochemistry... - Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumorsNorman L Lehman
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
J Neuropathol Exp Neurol 67:900-10. 2008..Cortical ependymomas and angiocentric gliomas may comprise a group of locally infiltrative ependymal tumors that are associated with an excellent prognosis after gross total surgical resection... - Dural marginal zone lymphoma with massive amyloid deposition: rare low-grade primary central nervous system B-cell lymphoma. Case reportNorman L Lehman
Department of Pathology, Stanford University Medical Center, California 94305-5324, USA
J Neurosurg 96:368-72. 2002..Extranodal MZL is a rare low-grade primary CNS B-cell lymphoma that may be associated with amyloidosis. It should be considered in the differential diagnosis of CNS lymphoproliferative lesions and CNS amyloidosis... - Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescenceEmmy W Verschuren
Department of Tumor Biology and Angiogenesis, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Mol Cell Biol 27:7955-65. 2007..Our data suggest that maintenance of a protein stabilization/mRNA expression positive-feedback circuit fueled by Emi1 is required for accurate cell cycle progression, maintenance of DNA integrity, and prevention of cellular senescence... - Central nervous system tumors with ependymal features: a broadened spectrum of primarily ependymal differentiation?Norman L Lehman
Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
J Neuropathol Exp Neurol 67:177-88. 2008..These issues are addressed in the context of early morphologic insights of Bailey and Cushing, Friede, and others; contemporary oncologic concepts; and recent relevant molecular and tumor stem cell studies... - GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosisHae Kyung Lee
Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
Neuro Oncol 10:236-43. 2008..Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors... - Histologic findings of disc, end plate and neural elements after coblation of nucleus pulposus: an experimental nucleoplasty studyYung C Chen
Spinal Diagnostics and Treatment Center, Daly City, CA 94015, USA
Spine J 3:466-70. 2003..Nucleoplasty, a new minimally invasive procedure using patented coblation technology, combines coagulation and ablation for partial removal of the nucleus pulposus to decompress the disc... - Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivoAustin M Guo
Henry Ford Hospital, Detroit, Michigan 48202, USA
J Pharmacol Exp Ther 327:10-9. 2008..This suggests that 20-HETE may have proto-oncogenic properties in U251 human gliomas. Further studies are needed to determine whether 20-HETE plays a role promoting growth of some human gliomas...
Research Grants
- Control of Genomic Stability by Emi1 and SecurinNORMAN LEHMAN; Fiscal Year: 2007..abstract_text> ..