Calvin Kuo

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain
    C J Kuo
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston Massachusetts 02115, USA
    J Cell Biol 152:1233-46. 2001
  2. ncbi Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    Akifumi Ootani
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 15:701-6. 2009
  3. ncbi Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    Richard Daneman
    Stanford University School of Medicine, Department of Developmental Biology, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:641-6. 2009
  4. ncbi Endochondral ossification is required for haematopoietic stem-cell niche formation
    Charles K F Chan
    Department of Pathology, Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
    Nature 457:490-4. 2009
  5. ncbi Increased hemoglobin associated with VEGF inhibitors in advanced renal cell carcinoma
    Lauren C Harshman
    Stanford University School of Medicine, California 94305, USA
    Cancer Invest 27:851-6. 2009
  6. ncbi Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth
    Nihar R Nayak
    Department of Gynecology and Obstetrics, Stanford University, Stanford, CA 94305 5317, USA
    Mol Hum Reprod 11:791-9. 2005
  7. ncbi Adenovirus-mediated delivery of a soluble form of the VEGF receptor Flk1 delays the growth of murine and human pancreatic adenocarcinoma in mice
    Jennifer F Tseng
    Department of Genetics, Harvard Medical School, and Division of Molecular Medicine, Children's Hospital, and Surgical Research Laboratories, Children's Hospital, Boston, Mass 02115, USA
    Surgery 132:857-65. 2002
  8. ncbi VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
  9. ncbi Wnts as essential growth factors for the adult small intestine and colon
    Jana Hoffman
    Department of Medicine, Hematology Division, Stanford University School of Medicine, California 94305, USA
    Cell Cycle 3:554-7. 2004
  10. ncbi Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    Frank Kuhnert
    Department of Medicine, Stanford University School of Medicine, Center for Clinical Sciences Research 3100, 269 Campus Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:266-71. 2004

Research Grants

  1. Wnt Proteins During Intestinal Repair and Regeneration
    Calvin Kuo; Fiscal Year: 2009
  2. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
  3. Regulation of CNS Angiogenesis By GPR124
    Calvin Kuo; Fiscal Year: 2009
  4. Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture
    Calvin J Kuo; Fiscal Year: 2010
  5. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
  6. Regulation of Adult CNS Angiogenesis by GPR124
    Calvin J Kuo; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. ncbi Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain
    C J Kuo
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston Massachusetts 02115, USA
    J Cell Biol 152:1233-46. 2001
    ..These data indicate that the collagen XVIII NC1 region encodes a motogen strictly requiring ES domain oligomerization and suggest a previously unsuspected mechanism for ECM regulation of motility and morphogenesis...
  2. ncbi Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    Akifumi Ootani
    Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 15:701-6. 2009
    ..Our results indicate successful long-term intestinal culture within a microenvironment accurately recapitulating the Wnt- and Notch-dependent ISC niche...
  3. ncbi Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    Richard Daneman
    Stanford University School of Medicine, Department of Developmental Biology, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:641-6. 2009
    ..Taken together these experiments reveal an essential role for Wnt/beta-catenin signaling in driving CNS-specific angiogenesis and provide molecular evidence that angiogenesis and BBB formation are in part linked...
  4. ncbi Endochondral ossification is required for haematopoietic stem-cell niche formation
    Charles K F Chan
    Department of Pathology, Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
    Nature 457:490-4. 2009
    ..Collectively, our data implicate endochondral ossification, bone formation that proceeds through a cartilage intermediate, as a requirement for adult HSC niche formation...
  5. ncbi Increased hemoglobin associated with VEGF inhibitors in advanced renal cell carcinoma
    Lauren C Harshman
    Stanford University School of Medicine, California 94305, USA
    Cancer Invest 27:851-6. 2009
    ..2 months with rises > 15%. This study identifies increased hemoglobin as a possible consequence of VEGF inhibitors. The correlation with longer PFS suggests that rise in hemoglobin may be a surrogate biomarker of efficacy...
  6. ncbi Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth
    Nihar R Nayak
    Department of Gynecology and Obstetrics, Stanford University, Stanford, CA 94305 5317, USA
    Mol Hum Reprod 11:791-9. 2005
    ..These data suggest, for the first time, that Ang-1 may play a key role in the P-dependent growth of the unique spiral arteries in the primate endometrium...
  7. ncbi Adenovirus-mediated delivery of a soluble form of the VEGF receptor Flk1 delays the growth of murine and human pancreatic adenocarcinoma in mice
    Jennifer F Tseng
    Department of Genetics, Harvard Medical School, and Division of Molecular Medicine, Children's Hospital, and Surgical Research Laboratories, Children's Hospital, Boston, Mass 02115, USA
    Surgery 132:857-65. 2002
    ..These studies suggest that the delivery of gene products such as Flk1-Fc through in vivo gene transfer may be useful in the future treatment of patients with pancreatic cancer...
  8. ncbi VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
    ..In summary, we provide novel experimental data indicating that VEGF is essential for endometrial neoangiogenesis during postmenstrual/postpartum repair...
  9. ncbi Wnts as essential growth factors for the adult small intestine and colon
    Jana Hoffman
    Department of Medicine, Hematology Division, Stanford University School of Medicine, California 94305, USA
    Cell Cycle 3:554-7. 2004
    ....
  10. ncbi Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    Frank Kuhnert
    Department of Medicine, Stanford University School of Medicine, Center for Clinical Sciences Research 3100, 269 Campus Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:266-71. 2004
    ....
  11. ncbi Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
    Samira Benhamouche
    Institut Cochin, Département GDPM, INSERM U567, CNRS, UMR S 8104, Paris, F 75014, France
    Dev Cell 10:759-70. 2006
    ..From our results, we propose that Apc is the liver "zonation-keeper" gene...

Research Grants23

  1. Wnt Proteins During Intestinal Repair and Regeneration
    Calvin Kuo; Fiscal Year: 2009
    ....
  2. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ....
  3. Regulation of CNS Angiogenesis By GPR124
    Calvin Kuo; Fiscal Year: 2009
    ..Finally, conditional approaches to GPR124 inactivation will be pursued using adenoviral and conditional knockout strategies, to facilitate the eventual study of GPR124 function in fully adult organisms. ..
  4. Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture
    Calvin J Kuo; Fiscal Year: 2010
    ....
  5. VEGF-dependent and - Independent Anti-angiogenic Therapy
    Calvin Kuo; Fiscal Year: 2006
    ..Moreover, these humanized receptors will be expressed from regulated adenoviruses to confer an additional degree of safety as a prelude to eventual clinical use. ..
  6. Regulation of Adult CNS Angiogenesis by GPR124
    Calvin J Kuo; Fiscal Year: 2010
    ..We will study a new receptor and its role in controlling adult blood vessel growth towards developing new therapies for conditions such as stroke and brain vascular malformations. ..