Research Topics
Species | Holbrook E KohrtSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
An ecological-transactional model of significant risk factors for child psychopathology in outer mongoliaHolbrook E Kohrt
Division of Child and Adolescent Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, MC 5719, Stanford, CA 94305, USA
Child Psychiatry Hum Dev 35:163-81. 2004..Structural equation modeling provides a useful technique to isolate specific sites for intervention, while maintaining a comprehensive perspective of risk factor interaction...- New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patientsHolbrook E Kohrt
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
BMC Cancer 8:66. 2008..Our goal was to develop new models to quantify the risk of NSLN metastasis in SLN-positive patients and to compare predictive capabilities to another widely used model... - Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancerHolbrook E Kohrt
Department of Medicine, Division of Oncology, Stanford University, Stanford, California, USA
J Clin Invest 122:1066-75. 2012.... - Treatment advances have not improved the early death rate in acute promyelocytic leukemiaJames Scott McClellan
Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305 5821, USA
Haematologica 97:133-6. 2012..Our findings show that early death is now the greatest contributor to treatment failure in this otherwise highly curable form of leukemia... - Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironmentAsh A Alizadeh
Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
Blood 118:1350-8. 2011..We conclude that the measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with DLBCL... - CD8+CD44(hi) but not CD4+CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHDSuparna Dutt
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Blood 117:3230-9. 2011..In conclusion, the memory CD8(+) T-cell subset separated graft antilymphoma activity from GVHD more effectively than naive T cells, memory CD4(+) T cells, or memory total T cells... - CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodiesHolbrook E Kohrt
Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305, USA
Blood 117:2423-32. 2011..These results support a novel, sequential antibody approach against B-cell malignancies by targeting first the tumor and then the host immune system... - Quantitative, architectural analysis of immune cell subsets in tumor-draining lymph nodes from breast cancer patients and healthy lymph nodesA Francesca Setiadi
Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 5:e12420. 2010..To gain additional mechanistic and prognostic insights, a need for quantitative architectural analysis arises in studying immune cell-cancer interactions within the tumor microenvironment and tumor-draining lymph nodes (TDLNs)... - Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphomaMark P Chao
Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford University, Palo Alto, CA 94304, USA
Cell 142:699-713. 2010..These antibodies synergized through a mechanism combining Fc receptor (FcR)-dependent and FcR-independent stimulation of phagocytosis that might be applicable to many other cancers... - Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cellsMatthew J Goldstein
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Cancer Res 72:1239-47. 2012..In conclusion, our findings identify 2 surface markers that can be used to facilitate the enrichment of antitumor CD4 T cells while depleting an inhibitory T(reg) population... - Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancerHolbrook E Kohrt
Division of Hematology, Department of Medicine, Stanford University, Stanford, California, USA
PLoS Med 2:e284. 2005..CONCLUSION: These findings demonstrate that the immune profile of tumor-draining lymph nodes is of novel biologic and clinical importance for patients with early stage breast cancer... - Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: a single-center experienceHolbrook E Kohrt
Department of Medicine, Division of Hematology, Stanford University, Stanford, CA 94305, USA
Am J Hematol 85:877-81. 2010..3 and 7.6 months, P = 0.36). Despite risk stratification by the European Prognostic Index, our series demonstrates inferior rates of response and survival, illustrating the limited activity of this regimen in our cohort... - Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemiaBruno C Medeiros
Department of Medicine, Division of Hematology, Stanford University School of Medicine, California, USA
Am J Hematol 87:45-50. 2012..The trial was registered on www.ClinicalTrials.gov as #NCT00611247... - Cytotoxic T lymphocyte responses against melanocytes and melanomaGwendolen Y Chang
Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA
J Transl Med 9:122. 2011..To uncouple vitiligo from melanoma destruction, it is important to understand if CTLs can respond against melanoma and melanocytes at different levels... - Acute myeloid leukaemia in the elderly: a reviewDaniel A Pollyea
Divisions of Hematology and Oncology, Department of Internal Medicine, University Cancer Center, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305, USA
Br J Haematol 152:524-42. 2011..Elderly patients, with their narrow therapeutic window, are well positioned to derive a benefit from these novel agents, and therefore, despite a difficult past, there are reasons to be optimistic about the future of elderly AML... - NKT cells, Treg, and their interactions in bone marrow transplantationHolbrook E Kohrt
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Eur J Immunol 40:1862-9. 2010..In addition, we also examine the interactions between NKT cells and Treg in the context of BMT, and integrate the data from murine experimental models with the observations made in humans... - TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donorsHolbrook E Kohrt
Department of Medicine, Stanford University School of Medicine, CA 94305, USA
Blood 114:1099-109. 2009..Active trial registration currently at clinicaltrials.gov under IDs of NCT00185640 and NCT00186615... - Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletionRoch Houot
Department of Medicine, Division of Oncology, Stanford University, CA, USA
Blood 114:3431-8. 2009..Moreover, the antitumor activity of anti-CD137 mAb could be further enhanced by depletion of regulatory T cell (T(regs)). These results support the evaluation of anti-CD137 therapy in clinical trials for patients with lymphoma... - Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2)Bruno C Medeiros
Department of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA
Leuk Res 34:594-7. 2010..2). Differential karyotype and expression of certain antigens were noted in patients with de novo AML with inv(3)(q21q26.2) vs. those with inv(3)(q21q26.2)-containing blasts... - Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responsesHolbrook E Kohrt
Department of Medicine, Division of Hematology, Stanford University, Stanford, California 94305, USA
J Immunother (1997) 28:297-305. 2005..Techniques, as presented here, that rapidly assess the overall antigen sensitivity, recognition efficiency, and functional status of patients' T-cell responses will guide future vaccine trials and immunotherapies... - Distribution of distress in post-socialist Mongolia: a cultural epidemiology of yadargaaBrandon A Kohrt
Department of Anthropology, Emory University, 1557 Pierce Drive, Atlanta, GA 30322, USA
Soc Sci Med 58:471-85. 2004..In conclusion, yadargaa strongly associates with disenfranchised groups in the capitalist economy. As a culturally constructed indicator of quality of life, yadargaa is a window into the lives of women and men in post-socialist Mongolia...