Research Topics
Species | Y H ChienSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Antigen recognition by gammadelta T cellsYueh Hsiu Chien
Department of Microbiology and Immunology, Program in Immunology, Stanford University, Stanford, CA, USA
Immunol Rev 215:46-58. 2007..That this CDR3 motif is important in antigen recognition is confirmed by the crystal structure of a gammadelta TCR bound to its ligand. The significance of these observations is discussed in the context of gammadelta T-cell biology...- Gamma delta T cell receptorsY H Chien
The Department of Microbiology and Immunology, and the Program in Immunology, Stanford University, Beckman B255, 279 Campus Drive, Stanford, California 94305, USA
Cell Mol Life Sci 63:2089-94. 2006..During the past year, there have been noteworthy advances in this area. Their significance in the context of gamma delta T cell biology is discussed... - Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profileA M Fahrer
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 98:10261-6. 2001..This study provides a strong basis for further investigations of the roles of these cells as well as mucosal immune defense in general... - Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodiesP A Reay
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
J Immunol 164:5626-34. 2000..The analysis indicates that T cell activation is a stochastic process... - The nature of major histocompatibility complex recognition by gamma delta T cellsH Schild
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305
Cell 76:29-37. 1994..These results suggest that the molecular nature of gamma delta T cell recognition is fundamentally different than that of alpha beta T cells... - An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cellsErin J Adams
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
Nat Immunol 9:777-84. 2008..Our results demonstrate unprecedented autonomy of a single CDR3 loop in antigen recognition... - Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gammaKirk D C Jensen
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Immunity 29:90-100. 2008..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens... - Antigen recognition determinants of gammadelta T cell receptorsSunny Shin
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 308:252-5. 2005..These results show how an antigen-specific gammadelta TCR repertoire can be generated at a high frequency and suggest that gammadelta T cells recognize a limited number of antigens... - The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activationChristiane Gerke
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 201:361-71. 2005..This is the first example showing that a pathogen targets these adaptor proteins in the TCR signaling pathway, suggesting a novel mechanism by which pathogens may efficiently alter T cell-mediated immune responses... - Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD miceFelix J Baker
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:9374-9. 2002..Thus, autoimmune diabetes in NOD may be initiated by a limited number of antigens distinct from GAD65 and insulin... - Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22Erin J Adams
Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94035 5124, USA
Science 308:227-31. 2005..That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies...
Research Grants
- MECHANISMS OF ORAL TOLERANCEYueh Hsiu Chien; Fiscal Year: 2002..The information may also be important for mucosal vaccine development. ..
- MHC AND GAMMA/DELTA T-CELL RECOGNITIONYueh Hsiu Chien; Fiscal Year: 2007..abstract_text> ..
- Ligands of Gamma Delta T Cell Antigen ReceptorsYueh Hsiu Chien; Fiscal Year: 2009..Our goal is to gain a better understanding of the gamma/delta TCR repertoire, the manner in which it is regulated and the role of these specificities in the larger context of an immune response. ..
- MHC AND GAMMA/DELTA T CELL RECOGNITIONYueh Hsiu Chien; Fiscal Year: 2002....
- MHC AND GAMMA/DELTA T-CELL RECOGNITIONYueh Hsiu Chien; Fiscal Year: 1993..A clear understanding of how gammadelta T cells recognize these well studied molecules will provide insight into the nature of gammadelta T cell specificity and help to better define their role in the immune system...
- Regulation and biological impact of IL-17 production by gamma delta T cellsYueh Hsiu Chien; Fiscal Year: 2010..While it is largely an starts the resolution program and in vertebrates, it has evolved to require a T cell cytokine, launches the adaptive immune .2) (U) =w' pay -,Q" ,tea --6 E'6 0 =-0 0-0 ono ..