Research Topics
Genomes and Genes | Euan AshleySummaryAffiliation: Stanford University Country: USA Publications
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Publications
The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivoEuan A Ashley
Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
Cardiovasc Res 65:73-82. 2005..The endogenous peptide apelin is differentially regulated in cardiovascular disease but the nature of its role in cardiac function remains unclear...- Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exerciseEuan A Ashley
Division of Cardiology, Stanford University, Stanford, California 94305, USA
J Am Coll Cardiol 48:523-31. 2006..The purpose of this study was to investigate the phenomenon of left ventricular (LV) dysfunction after ultraendurance exercise... - Preoperative cardiac evaluation: mechanisms, assessment, and reduction of riskEuan A Ashley
Division of Cardiology, Stanford University School of Medicine, Falk CVRB, 300 Pasteur Drive, Stanford, CA 94305, USA
Thorac Surg Clin 15:263-75. 2005.... - Network analysis of human in-stent restenosisEuan A Ashley
Division of Cardiovascular Medicine, Falk CVRC, Stanford University, Stanford, Calif 94305, USA
Circulation 114:2644-54. 2006..We analyzed human coronary atheroma in de novo and restenotic disease to identify targets of therapy that might avoid these limitations... - Clinical assessment incorporating a personal genomeEuan A Ashley
Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
Lancet 375:1525-35. 2010..The cost of genomic information has fallen steeply, but the clinical translation of genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a complete human genome in a clinical context... - Novel role for the potent endogenous inotrope apelin in human cardiac dysfunctionMary M Chen
Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Dr, Stanford, Calif 94305, USA
Circulation 108:1432-9. 2003..Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like 1 (APJ) signaling has ever been described... - Exercise testing scores as an example of better decisions through scienceEuan Ashley
Cardiology Division (111C, Veterans Affairs Palo Alto Health Care System, Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
Med Sci Sports Exerc 34:1391-8. 2002..CONCLUSION: Multivariate scores can empower the clinician to assure the cardiac patient with access to appropriate and cost-effective cardiological care... - Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouseYoko Kojima
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Cardiovasc Res 87:156-65. 2010..To investigate apelin-APJ (angiotensin receptor-like 1) signalling in vascular remodelling, we have examined the pathophysiological response to carotid ligation in apelin knockout mice... - Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammationNicholas J Leeper
Division of Cardiovascular Medicine, Department of Medicine, Stanford Univ, 300 Pasteur Dr, Stanford, California 94305, USA
Am J Physiol Heart Circ Physiol 296:H1329-35. 2009..The mechanism appears to be decreased macrophage burden, perhaps related to an apelin-mediated decrease in proinflammatory cytokine and chemokine activation... - Endogenous regulation of cardiovascular function by apelin-APJDavid N Charo
Department of Medicine Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
Am J Physiol Heart Circ Physiol 297:H1904-13. 2009..Finally, differences in the developmental phenotype between apelin and APJ null mice suggest the possibility of undiscovered APJ ligands or ligand-independent effects of APJ... - Drug discovery in a multidimensional world: systems, patterns, and networksJoel T Dudley
Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA
J Cardiovasc Transl Res 3:438-47. 2010..When available, specific applications to cardiovascular drug discovery are highlighted and discussed... - New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapyFrancois Haddad
Division of Cardiovascular Medicine, Stanford School of Medicine, Palo Alto, California 94305, USA
Curr Opin Cardiol 25:131-40. 2010..Here, we review new insights on the pathophysiology, assessment and management of right ventricular failure... - Electrocardiographic predictors of atrial fibrillationMARCO V PEREZ
Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
Am Heart J 158:622-8. 2009..Noninvasive predictors of AF may help identify patients at risk of developing AF. Our objective was to identify the electrocardiographic characteristics associated with onset of AF... - Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosisHyung J Chun
Department of Medicine and Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 118:3343-54. 2008..Taken together, these findings indicate that apelin signaling can block Ang II actions in vascular disease by increasing NO production and inhibiting Ang II cellular signaling... - Ventricular arrhythmias during clinical treadmill testing and prognosisFrederick E Dewey
Stanford University Medical School, Palo Alto, California, USA
Arch Intern Med 168:225-34. 2008..Therefore, we aimed to evaluate the clinical correlates and prognostic significance of exercise-associated premature ventricular complexes (PVCs) during and after exercise testing... - The concept of ventricular reserve in heart failure and pulmonary hypertension: an old metric that brings us one step closer in our quest for predictionFrancois Haddad
Stanford University School of Medicine, Falk Cardiovascular Research Center, Palo Alto, California, USA
Curr Opin Cardiol 26:123-31. 2011..Ventricular reserve is the term used to describe the extent of increase or change in ventricular function that occurs during exercise or pharmacological stress (typically with dobutamine)... - Statin use and ventricular arrhythmias during clinical treadmill testingFrederick E Dewey
Department of Internal Medicine, Stanford University, Palo Alto, California, USA
J Cardiovasc Electrophysiol 20:193-9. 2009..Statin use reduces the incidence of resting ventricular arrhythmias in patients with coronary artery disease; however, the relationship between statin use and exercise-induced ventricular arrhythmias has not been investigated... - Prognostic value of heart rate increase at onset of exercise testingNicholas J Leeper
Stanford University Medical Center, Stanford University Medical School, Calif, USA
Circulation 115:468-74. 2007..Our aim was to evaluate the prognostic value of early heart rate parameters in patients referred for routine clinical treadmill testing... - Low-dose growth hormone is cardioprotective in uremiaRalph Rabkin
Department of Medicine, Stanford University and Research Service, Veterans Administration Health Care System, Palo Alto, California 94304, USA
J Am Soc Nephrol 19:1774-83. 2008..In contrast, high-dosage GH worsened several of these variables. These results suggest that low-dosage GH may benefit the heart and possibly the carotid arteries in chronic renal failure... - Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular diseaseRaymond Tabibiazar
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Arterioscler Thromb Vasc Biol 25:302-8. 2005..In this study, we sought to identify the genetic pathways that are differentially activated in the aortas of these mice... - Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mousePatrick Yue
Division of Cardiovascular Medicine, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
Am J Physiol Heart Circ Physiol 292:H2106-18. 2007..In summary, as assessed by CMR, db/db mice develop characteristic structural and functional changes consistent with cardiomyopathy... - Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary diseaseRaymond Tabibiazar
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford, CA, USA
Physiol Genomics 22:213-26. 2005.... - The prognostic value of early repolarization with ST-segment elevation in African AmericansMARCO V PEREZ
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California
Heart Rhythm 9:558-65. 2012..The prognostic value of this pattern in different ethnicities remains controversial... - The impact of ST elevation on athletic screeningTroy Leo
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Clin J Sport Med 21:433-40. 2011..To demonstrate the prevalence and patterns of ST elevation (STE) in ambulatory individuals and athletes and compare the clinical outcomes... - Insights into human beta-cardiac myosin function from single molecule and single cell studiesSivaraj Sivaramakrishnan
Department of Biochemistry, Stanford University, Stanford, CA, USA
J Cardiovasc Transl Res 2:426-40. 2009..Finally, we examine the technical challenges specific to studying beta-cardiac myosin function both using single molecule and single cell approaches... - Better decisions through science: exercise testing scoresVictor Froelicher
Cardiology Division, Veterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, CA 94304, USA
Prog Cardiovasc Dis 44:395-414. 2002..Assessment of the clinical and exercise test data and application of the newer scores can empower the clinician to assure the cardiac patient access to appropriate and cost-effective cardiologic care... - Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery diseaseMark A Hlatky
Stanford University School of Medicine, Stanford, CA 94305 5405, USA
Am Heart J 154:1043-51. 2007..The aim of this study was to assess systematic differences between patients with acute myocardial infarction (MI) and patients with stable angina in matrix metalloproteinase (MMP) circulating levels and genetic polymorphisms... - Age and double product (systolic blood pressure x heart rate) reserve-adjusted modification of the Duke Treadmill Score nomogram in menAmir H Sadrzadeh Rafie
Stanford University School Medicine, Stanford, CA, USA
Am J Cardiol 102:1407-12. 2008..In conclusion, we propose an age and DP reserve-adjusted DTS nomogram that improves the prognostic estimates of average annual CVD over the DTS alone... - Pathway analysis of coronary atherosclerosisJennifer Y King
Donald W. Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, Stanford, California 94305, USA
Physiol Genomics 23:103-18. 2005.... - Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activationJoshua M Spin
Donald W. Reynolds Cardiovascular Clinical Research Center, Stanford University School of Medicine, Stanford, California 94305, USA
Physiol Genomics 19:292-302. 2004..In addition to confirming the utility of the A404 model, our data provide a large-scale perspective of gene regulation during SMC differentiation... - Progressive Dyspnea After CABG: Complication of Retained Epicardial Pacing WiresGeorge S Horng
Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California 94305, USA
Ann Thorac Surg 86:1352-4. 2008..Removal of the wires by open thoracotomy resulted in significant improvement in dyspnea and near complete resolution of the bronchiectasis and consolidation... - A new era in clinical genetic testing for hypertrophic cardiomyopathyMatthew Wheeler
The Stanford Center for Inherited Cardiovascular Disease, Stanford School of Medicine, Falk CVRB, Stanford, CA 94305, USA
J Cardiovasc Transl Res 2:381-91. 2009..In summary, our future will be characterized not by lack of genetic information but by our ability to effectively parse it... - Does size matter? Clinical applications of scaling cardiac size and function for body sizeFrederick E Dewey
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Circulation 117:2279-87. 2008..Lack of appropriate consideration of body size in the evaluation of cardiovascular structure and function may adversely affect recognition and treatment of cardiovascular disease states in the adult patient... - Perioperative cardiac risk: pathophysiology, assessment and managementRamachandra R Sista
Stanford University, Division of Pulmonary and Critical Care Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Expert Rev Cardiovasc Ther 4:731-43. 2006.... - Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathyVy Van Le
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Am Heart J 158:e27-34. 2009..To determine the relation between echocardiogram findings and exercise capacity in hypertrophic cardiomyopathy (HCM)... - Electrocardiographic arrhythmia risk testingGregory Engel
Stanford University, Stanford, CA, USA
Curr Probl Cardiol 29:365-432. 2004..It is likely that a combination of risk evaluation techniques will have the greatest predictive power in enabling identification of patients most likely to benefit from device therapy... - Addition of the electrocardiogram to the preparticipation examination of college athletesVy Van Le
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94304, USA
Clin J Sport Med 20:98-105. 2010..Because the impact of ECG screening on college athletes has rarely been reported, we analyzed the findings of adding the ECG to the PPE of Stanford athletes... - Frontiers in nephrology: genomic approaches to understanding the molecular basis of atherosclerosisEuan A Ashley
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
J Am Soc Nephrol 18:2853-62. 2007..In this comparison of these differing approaches, the available data are synthesized to reach a new understanding of the complex interplay between vascular wall and immune system components... - Emerging therapies for the management of decompensated heart failure: from bench to bedsideEmil M deGoma
Stanford University, Stanford, California 94305, USA
J Am Coll Cardiol 48:2397-409. 2006..These advances allow optimism not only for the advancement of our understanding and management of decompensated heart failure syndromes but for the translational research effort in heart failure biology in general... - Cost-effectiveness of preparticipation screening for prevention of sudden cardiac death in young athletesMatthew T Wheeler
Stanford University, California 94305, USA
Ann Intern Med 152:276-86. 2010..Inclusion of 12-lead electrocardiography (ECG) in preparticipation screening of young athletes is controversial because of concerns about cost-effectiveness... - Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytesEuan A Ashley
University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
Circulation 105:3011-6. 2002..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction... - Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?Claire E Sears
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Philos Trans R Soc Lond B Biol Sci 359:1021-44. 2004..Whether or not the role of nNOS carries implications for cardiovascular disease remains an intriguing possibility requiring future study... - Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handlingClaire E Sears
Department of Cardiovascular Medicine, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Circ Res 92:e52-9. 2003..The full text of this article is available at http://www.circresaha.org... - Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failureKwok Shiong Chong
Glasgow Royal Infirmary, Scottish Cardiopulmonary Transplant Unit, 10 Alexandra Parade, G31 2ER Glasgow, Scotland, United Kingdom
Eur J Heart Fail 8:355-60. 2006..Our aim was to evaluate plasma apelin concentrations in a large cohort of patients with chronic heart failure (CHF) across a broad spectrum of disease severity... - Diagnosing coronary artery disease in diabetic patientsEuan A Ashley
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Diabetes Metab Res Rev 18:201-8. 2002..Other diagnostic tools are considered, and recommendations are made with respect to screening asymptomatic diabetic patients for coronary artery disease...
Research Grants
- Integrative Cardiovascular Biology of Apelin-APJEuan Ashley; Fiscal Year: 2007..The experiments described herein will provide a sound mechanistic basis for the future translation of this body of work to the clinical domain. (End of Abstract) ..
- Nanoscale approaches to allelic silencing in myocardial disease statesEuan Ashley; Fiscal Year: 2009..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..