Research Topics
Genomes and GenesSpecies | James IhleSummaryAffiliation: St. Jude Children's Research Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Signaling by the cytokine receptor superfamilyJ N Ihle
Howard Hughes Medical Institute, Department of Biochemistry, Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Ann N Y Acad Sci 865:1-9. 1998..Each Stat family member plays a critical role in the biological functions of specific cytokines as demonstrated by the phenotype of mice lacking one or more of these genes...- The Stat family in cytokine signalingJ N Ihle
Department of Biochemistry, Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
Curr Opin Cell Biol 13:211-7. 2001.... - Jak2: normal function and role in hematopoietic disordersJames N Ihle
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Curr Opin Genet Dev 17:8-14. 2007..Recent studies have implicated de-regulation of Jak2 kinase activity by chromosomal translocations in hematopoietic tumors and mutations within the pseudokinase domain in a spectrum of myeloproliferative diseases... - Evi-1 expression in XenopusPaul E Mead
Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Gene Expr Patterns 5:601-8. 2005..Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck... - Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activityMegumi Funakoshi-Tago
Department of Biochemistry, D4013, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
Mol Cell Biol 28:1792-801. 2008.... - Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing proteinNick Carpino
Department of Biochemistry, St Jude Children s Research Hospital, and University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
Mol Cell Biol 22:7491-500. 2002..In addition, no impairment in B- and T-cell development and proliferative ability was detected... - SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiationYutaka Takahashi
Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
EMBO J 22:372-84. 2003..Finally, LIFR deficiency rescues the SOCS3-deficient placental defect and embryonic lethality. The results establish SOCS3 as an essential regulator of LIFR signaling in trophoblast differentiation... - SOCS3 regulates the plasticity of gp130 signalingRoland Lang
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nat Immunol 4:546-50. 2003..Thus, SOCS3 functions to control the quality of the response to IL-6 and prevents the activation of an IFN-induced program of gene expression... - Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2Megumi Funakoshi-Tago
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 3810, USA
EMBO J 25:4763-72. 2006..This regulation occurs with the receptors for Epo, thrombopoietin and growth hormone but not with the receptor for interferon-gamma... - Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenaseRoland P Piekorz
Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Mol Endocrinol 19:431-40. 2005.... - Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and functionStephane Pelletier
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Mol Cell Biol 26:8527-38. 2006..Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity... - Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signalingSebastien Gingras
Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Biol Chem 279:54702-7. 2004..We conclude that previous reports linking SOCS1 to TLR signaling are most likely due to effects on IFN-alpha/beta receptor signaling... - Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell developmentNick Carpino
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Mol Cell Biol 24:2584-92. 2004..Mice deficient in Jak3 exhibit a SCID phenotype but harbor a residual B220+ splenic lymphocyte population. We demonstrate here that this residual lymphocyte population is lost in mice lacking both the gamma-like chain and Jak3... - The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosisRoland P Piekorz
Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38105, USA
EMBO J 21:653-64. 2002..The results support the concept that TACC3 is a critical component of the centrosome/mitotic spindle apparatus and its absence triggers p53-mediated apoptosis... - A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profilingMartina Gatzka
Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38120, USA
Cytokine 34:143-54. 2006.... - Determination of the transphosphorylation sites of Jak2 kinaseTadashi Matsuda
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Biochem Biophys Res Commun 325:586-94. 2004..Additionally, non-Jak family conserved tyrosines are phosphorylated suggesting that the individual Jaks ability to phosphorylated specific tyrosines may influence signals emitting from activated Jaks... - Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5Kevin D Bunting
Hematopoiesis Department, American Red Cross Holland Laboratory, Rockville, MD, USA
Blood 99:479-87. 2002..These results demonstrate that a significant proportion of the growth factor signals required for multilineage reconstitution potential of HSCs is STAT5 dependent... - Stat5 tetramer formation is associated with leukemogenesisRichard Moriggl
Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Cancer Cell 7:87-99. 2005..In addition, Stat5 tetramers were found to accumulate in excess compared to dimers in various human leukemias. These data suggest that Stat5 tetramers are associated with leukemogenesis...
Research Grants
- HematopoiesisJames Ihle; Fiscal Year: 2004..abstract_text> ..
- INTERLEUKIN-3 REGULATED GROWTH HEMATOPOIETIC CELLSJames Ihle; Fiscal Year: 2002..abstract_text> ..
- INTERLEUKIN-3 REGULATED GROWTH OF HEMATOPOIETIC CELLSJames Ihle; Fiscal Year: 1993..Together these approaches will identify new genes that are involved in the growth regulation of hematopoietic cells and better our understanding of the growth and differentiation of myeloid cells...
- Cytokine Regulated Growth Of Hematopoietic CellsJames Ihle; Fiscal Year: 2007..Both genetic approaches and biochemical approaches are proposed to identify components of this pathway. ..