D W Borhani

Summary

Affiliation: Southern Research Institute
Country: USA

Publications

  1. ncbi Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution
    Anthony E Klon
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294, USA
    J Mol Biol 320:677-93. 2002
  2. ncbi Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
    D W Borhani
    Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35205, USA
    Proc Natl Acad Sci U S A 94:12291-6. 1997
  3. ncbi Crystallization of truncated human apolipoprotein A-I in a novel conformation
    D W Borhani
    Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35205, USA
    Acta Crystallogr D Biol Crystallogr 55:1578-83. 1999
  4. ncbi Human apolipoprotein A-I: structure determination and analysis of unusual diffraction characteristics
    D W Borhani
    Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35205, USA
    Acta Crystallogr D Biol Crystallogr 55:2013-21. 1999
  5. ncbi Slow polymerization of Mycobacterium tuberculosis FtsZ
    E L White
    Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    J Bacteriol 182:4028-34. 2000
  6. ncbi Michellamine alkaloids inhibit protein kinase C
    E L White
    Department of Biochemistry, Southern Research Institute, Birmingham, Alabama 35205, USA
    Arch Biochem Biophys 365:25-30. 1999
  7. ncbi Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ
    A K Leung
    Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    Acta Crystallogr D Biol Crystallogr 56:1634-7. 2000
  8. ncbi Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches
    Adelaine K W Leung
    Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    J Mol Biol 342:953-70. 2004
  9. ncbi Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation
    Robert C Reynolds
    Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA
    J Med Chem 50:3283-9. 2007
  10. ncbi A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection
    David W Borhani
    Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA
    Bioorg Med Chem Lett 14:2613-6. 2004

Collaborators

Detail Information

Publications11

  1. ncbi Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution
    Anthony E Klon
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294, USA
    J Mol Biol 320:677-93. 2002
    ..In both structures, a salt-bridge is formed between Arg70 in the active site and Glu44 from a symmetry-related molecule in the crystal lattice that mimics the binding of methotrexate to DHFR...
  2. ncbi Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
    D W Borhani
    Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35205, USA
    Proc Natl Acad Sci U S A 94:12291-6. 1997
    ..Based on this structure, we propose a model for the structure of apo A-I bound to high density lipoprotein...
  3. ncbi Crystallization of truncated human apolipoprotein A-I in a novel conformation
    D W Borhani
    Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35205, USA
    Acta Crystallogr D Biol Crystallogr 55:1578-83. 1999
    ..It is concluded, therefore, that apo Delta(1-43)A-I may have crystallized in one of these distinct conformations in the form II crystals...
  4. ncbi Human apolipoprotein A-I: structure determination and analysis of unusual diffraction characteristics
    D W Borhani
    Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35205, USA
    Acta Crystallogr D Biol Crystallogr 55:2013-21. 1999
    ..When flash-cooled to 100 K, the crystals diffract synchrotron radiation to 3 A resolution. Radiation sensitivity and crystal-to-crystal variation have hindered the assembly of a complete 3 A data set...
  5. ncbi Slow polymerization of Mycobacterium tuberculosis FtsZ
    E L White
    Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    J Bacteriol 182:4028-34. 2000
    ..tuberculosis FtsZ polymerization, inhibits GTP hydrolysis, and reduces the number and sizes of FtsZ polymers...
  6. ncbi Michellamine alkaloids inhibit protein kinase C
    E L White
    Department of Biochemistry, Southern Research Institute, Birmingham, Alabama 35205, USA
    Arch Biochem Biophys 365:25-30. 1999
    ..Molecular modeling showed that all three michellamines can bind in the active site cleft of the PKC kinase domain, to block both the ATP and the peptide substrate subsites...
  7. ncbi Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ
    A K Leung
    Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    Acta Crystallogr D Biol Crystallogr 56:1634-7. 2000
    ..Exceptional form II crystals diffract to at least 4.5 A resolution. Determination of the MtbFtsZ structure may advance the design of improved inhibitors of FtsZ polymerization...
  8. ncbi Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches
    Adelaine K W Leung
    Drug Discovery Division, Southern Research Institute, Birmingham, AL 35205, USA
    J Mol Biol 342:953-70. 2004
    ....
  9. ncbi Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation
    Robert C Reynolds
    Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA
    J Med Chem 50:3283-9. 2007
    ..The less toxic nido-carborane 2 was also tested as a candidate for boron neutron capture therapy, but showed poor tumor retention and low selectivity ratios for boron distribution in tumor tissue versus normal tissue...
  10. ncbi A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection
    David W Borhani
    Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA
    Bioorg Med Chem Lett 14:2613-6. 2004
    ..We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection...
  11. ncbi Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection
    Andrew Burchat
    Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA
    Bioorg Med Chem Lett 16:118-22. 2006
    ....