A Bril

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. ncbi Biophysical interaction between phospholamban and protein phosphatase 1 regulatory subunit GM
    I Berrebi-Bertrand
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    FEBS Lett 439:224-30. 1998
  2. ncbi The gamma-subunit of (Na+,K+)-ATPase: a representative example of human single transmembrane protein with a key regulatory role
    I Berrebi-Bertran
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Cell Mol Biol (Noisy-le-grand) 47:285-96. 2001
  3. ncbi Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide
    A Bril
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Cardiovasc Res 37:130-40. 1998
  4. ncbi Structure of the human glycogen-associated protein phosphatase 1 regulatory subunit hGM: homology modeling revealed an (alpha/beta)8-barrel-like fold in the multidomain protein
    M Souchet
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Protein Sci 8:2570-9. 1999
  5. ncbi Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties
    G Nadler
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Bioorg Med Chem 6:1993-2011. 1998
  6. ncbi Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury
    N Khandoudi
    GlaxoSmithKline Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, BP 96205, 35762 Cédex, Saint Grégoire, France
    Cardiovasc Res 52:387-96. 2001
  7. ncbi Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues
    S Krief
    SmithKline Beecham Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, BP 58, 35762 Saint Grégoire, France
    J Biol Chem 274:36592-600. 1999
  8. ncbi Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)
    I Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:C576-84. 1999
  9. ncbi EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes
    P Robert
    GlaxoSmithKline Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, 35762 Saint Grégoire, PA, BP 58, France
    J Mol Cell Cardiol 33:1589-606. 2001
  10. ncbi Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick
    E Mitrani
    Department of Zoology, Hebrew University of Jerusalem, Israel
    Cell 63:495-501. 1990

Collaborators

Detail Information

Publications11

  1. ncbi Biophysical interaction between phospholamban and protein phosphatase 1 regulatory subunit GM
    I Berrebi-Bertrand
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    FEBS Lett 439:224-30. 1998
    ..Thus, the interaction between PLB and GM may represent a specific way to modulate the SR function in human cardiac muscle...
  2. ncbi The gamma-subunit of (Na+,K+)-ATPase: a representative example of human single transmembrane protein with a key regulatory role
    I Berrebi-Bertran
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Cell Mol Biol (Noisy-le-grand) 47:285-96. 2001
    ..These proteins are critical in controlling important biological processes which derive from specific associations with a binding partner and particular subcellular localizations...
  3. ncbi Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide
    A Bril
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Cardiovasc Res 37:130-40. 1998
    ....
  4. ncbi Structure of the human glycogen-associated protein phosphatase 1 regulatory subunit hGM: homology modeling revealed an (alpha/beta)8-barrel-like fold in the multidomain protein
    M Souchet
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Protein Sci 8:2570-9. 1999
    ..This work highlights the presence of a conserved fold among distant species (mammalian, Caenorhabditis elegans, yeast) and, thus, emphasizes the involvement of PP1 in crucial basic cellular functions...
  5. ncbi Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties
    G Nadler
    SmithKline Beecham Laboratoires Pharmaceutiques, Saint Grégoire, France
    Bioorg Med Chem 6:1993-2011. 1998
    ..New derivatives depicting bell-shaped dose-response curves on action potential duration may therefore represent novel agents for improved antiarrhythmic therapy...
  6. ncbi Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury
    N Khandoudi
    GlaxoSmithKline Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, BP 96205, 35762 Cédex, Saint Grégoire, France
    Cardiovasc Res 52:387-96. 2001
    ..However, Na(+)-driven HCO(-)(3) transport, which is quantitatively as important as NHE in cardiac cells, has not been examined...
  7. ncbi Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues
    S Krief
    SmithKline Beecham Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, BP 58, 35762 Saint Grégoire, France
    J Biol Chem 274:36592-600. 1999
    ..Within cvHsp, amino acid residues 56-119 were shown to be important for its specific interaction with the C-terminal tail of alpha-filamin...
  8. ncbi Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)
    I Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:C576-84. 1999
    ..We conclude that hhNBC is an electrogenic Na+-HCO-3 cotransporter and that hkNBC is also electrogenic...
  9. ncbi EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes
    P Robert
    GlaxoSmithKline Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, 35762 Saint Grégoire, PA, BP 58, France
    J Mol Cell Cardiol 33:1589-606. 2001
    ..Altogether, our results show that S1P induces cardiomyocyte hypertrophy mainly via the EDG1 receptor and subsequently via Gi through ERKs, p38 MAPK, JNK, PI3K and via Rho pathway...
  10. ncbi Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick
    E Mitrani
    Department of Zoology, Hebrew University of Jerusalem, Israel
    Cell 63:495-501. 1990
    ....
  11. ncbi [Ion transporters and cardiovascular diseases: pH control or modulation of intracellular calcium concentration]
    A Bril
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, IFR 100, Facultés de Médecine et Pharmacie, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
    Ann Cardiol Angeiol (Paris) 52:41-51. 2003
    ..Therefore, inhibiting these transporters could represent novel therapeutic strategies for the treatment of cardiovascular diseases...