Research Topics
Genomes and Genes | Scott W AltmannSummaryAffiliation: Schering-Plough Research Institute Country: USA Publications
| Collaborators
|
Detail Information
Publications
Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasisHarry R Davis
Department of Cardiovascular Metabolic Disease and Department of Discovery Technologies, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
J Biol Chem 279:33586-92. 2004..NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis. Thus, NPC1L1 may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia...- The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorptionScott W Altmann
Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
Biochim Biophys Acta 1580:77-93. 2002..In contrast studies with SR-B1 knockout mice suggest that SR-B1 is not essential for intestinal cholesterol absorption or the activity of ezetimibe... - Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorptionScott W Altmann
Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
Science 303:1201-4. 2004..Ezetimibe, a drug that inhibits cholesterol absorption, had no effect in NPC1L1 knockout mice, suggesting that NPC1L1 resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption... - Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- miceHarry R Davis
Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Arterioscler Thromb Vasc Biol 27:841-9. 2007..The objective of this study was to determine whether the deficiency of Niemann-Pick C1 Like 1 (Npc1l1) prevents atherosclerosis in apoE null mice... - In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologsBrian E Hawes
Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, Kenilworth, New Jersey, USA
Mol Pharmacol 71:19-29. 2007..The results demonstrate that the ability of compounds to bind to NPC1L1 is the major determinant of in vivo responsiveness... - Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1)Harry R Davis
Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Atheroscler Suppl 9:77-81. 2008..Therefore, NPC1L1 is the critical intestinal sterol transporter which influences whole body cholesterol homeostasis, and is the molecular target of ezetimibe... - Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) proteinSai Prasad N Iyer
Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, 2015 Galloping Hill Rd, K15 3 3600, Kenilworth, NJ 07033, USA
Biochim Biophys Acta 1722:282-92. 2005..These biochemical data indicate that NPC1L1 exists as a predominantly cell surface membrane expressed protein, consistent with its proposed role as the putative intestinal sterol transporter... - Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporterHarry R Davis
Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Biochim Biophys Acta 1791:679-83. 2009..Therefore, NPC1L1 is a critical intestinal sterol uptake transporter which influences whole body cholesterol homeostasis... - Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitorsDuane A Burnett
Schering Plough Research Institute, 2015 Galloping Hill Road MS 2800, Kenilworth, NJ 07033 0539, USA
Bioorg Med Chem Lett 12:315-8. 2002..Biological testing reveals that they are potent CAIs and are suitable tools for the investigation of the azetidinone CAI mechanism of action (MOA)... - mRNA and 18S-RNA coapplication-reverse transcription for quantitative gene expression analysisLi-ji Zhu
Department of Cardiovascular/Metabolic Disease Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA
Anal Biochem 345:102-9. 2005..Co-RT provides increased sensitivity and higher accuracy than do the standard random primed RT methods... - The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)Margarita Garcia-Calvo
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 102:8132-7. 2005..These results unequivocally establish NPC1L1 as the direct target of ezetimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport...